ChemicalBook > CAS DataBase List > (R)-N-BOC-Propargylglycine

(R)-N-BOC-Propargylglycine

Product Name: (R)-N-BOC-Propargylglycine
CAS No.: 63039-46-3
Chemical Name: (R)-N-BOC-Propargylglycine
Synonyms: Boc-D-propraglycine;RARECHEM BK PT 0259;Boc-D-Propargyl-Gly-OH;BOC-D-PROPARGYLGLYCINE;Boc-D-Gly(propargyl)-OH;N-Boc-D-Propargylglycine;Boc-(R)-2-Propargylglycine;(R)-N-BOC-PROPARGYLGLYCINE;Boc-D-Propargylglycine ,98%;Boc-D-Propargylglycine.DCHA
CBNumber: CB0138392
Molecular Formula: C10H15NO4
Formula Weight: 213.23
MOL File: 63039-46-3.mol

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(R)-N-BOC-Propargylglycine Property

Melting point:: 86-88°
Boiling point:: 353.22°C (rough estimate)
Density: 1.2177 (rough estimate)
refractive index: 1.4368 (estimate)
storage temp.: 2-8°C
pka: 3.53±0.10(Predicted)
form: Crystalline Powder
color: Off-white to light beige
optical activity: -32.6364°(C=1.1311 g/100ml CHCL3)
InChI: InChI=1S/C10H15NO4/c1-5-6-7(8(12)13)11-9(14)15-10(2,3)4/h1,7H,6H2,2-4H3,(H,11,14)(H,12,13)/t7-/m1/s1
InChIKey: AMKHAJIFPHJYMH-SSDOTTSWSA-N
SMILES: C(O)(=O)[C@H](NC(OC(C)(C)C)=O)CC#C
CAS DataBase Reference: 63039-46-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
HS Code: 29224985

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

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N-Bromosuccinimide Price

TRC

Product number: B665880
Product name: Boc-D-Pra-OH
Packaging: 500mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: M087
Product name: Boc-D-Propargylglycine
Packaging: 1g
Price: $81
Updated: 2021/12/16

Activate Scientific

Product number: AS85204
Product name: Boc-(R)-2-Propargylglycine
Purity: 95+% ee
Packaging: 1g
Price: $106
Updated: 2021/12/16

Oakwood

Product number: 048698
Product name: N-Boc-2-Propargyl-D-glycine
Packaging: 250mg
Price: $150
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4558-1-02
Product name: D-2-Propargylglycine, N-Boc protected
Packaging: 1g
Price: $160
Updated: 2021/12/16

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(R)-N-BOC-Propargylglycine Chemical Properties,Usage,Production

Chemical Properties

off-white to light beige crystalline powder

Uses

(R)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a Glycine.html" class="link-product" target="_blank">Glycine (HY-Y0966) derivative[1]. (R)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Synthesis

24424-99-5

23235-01-0

61172-66-5

Step 5: Preparation of (R)-2-((tert-butoxycarbonyl)amino)pent-4-ynoic acid L-alkynylglycine (10 g) [prepared according to Schwyzer et al, Helv. Chim. Acta, 59, 2181 (1976)] was suspended in tetrahydrofuran (30 mL). To this suspension, water (30 mL), potassium carbonate (36.7 g) and di-tert-butyl dicarbonate (21.9 g) were added sequentially. Subsequently, additional water was added to completely dissolve the mixture and the resulting solution was stirred for 12 hours at room temperature. Upon completion of the reaction, the organic solvent was removed by evaporation. The remaining aqueous phase was washed with ether and then acidified with 1N aqueous citric acid to pH 3. The acidified aqueous phase was extracted with dichloromethane, and the organic phases were combined and the solvent was removed by evaporation to afford (R)-2-((tert-butoxycarbonyl)amino)pent-4-ynoic acid (18.9 g, 97% yield), and the product was ready to use in subsequent reactions without further purification.

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

(R)-N-BOC-Propargylglycine Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-N-BOC-Propargylglycine Suppliers

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View Lastest Price from (R)-N-BOC-Propargylglycine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-D-Propargylglycine 63039-46-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2023-10-07

Zhuozhou Wenxi import and Export Co., Ltd

Product: (R)-N-BOC-Propargylglycine 63039-46-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-10

Career Henan Chemical Co

Product: (R)-N-BOC-Propargylglycine 63039-46-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-24

63039-46-3, (R)-N-BOC-PropargylglycineRelated Search:

L-Propargylglycine (R)-METHYL-2-BOC-AMINO-4-PENTENOIC ACID METHYL-2-BOC-AMINO-4-PENTENOIC ACID DL-PROPARGYLGLYCINE (S)-N-BOC-Propargylglycine (R)-2-(((benzyloxy)carbonyl)aMino)pent-4-ynoic acid L-Propargylglycine HCL (R)-2-aminopent-4-ynoic acid (R)-N-BOC-Propargylglycine 4-Pentyn-1-ol D-PROPARGYLGLYCINE 4-Fluorocinnamic acid 4-PENTYNOIC ACID Cyclohexylamine DL-PROPARGYL-GLY-OH BOC-(R)-ALPHA-PROPYNYL-PROLINE Carbamic acid, [(1R)-1-(hydroxymethyl)-2-propynyl]-, 1,1-dimethylethyl ester BOC-D-PRA-OH DCHA

(R)-(1-Hydroxymethyl-but-3-ynyl)-carbamic acid tert-butyl ester

(R)-2-tert-Butoxycarbonylamino-pent-4-ynoic acid

Boc-D-Propargylglycine.DCHA

(R)-N-BOC-PROPARGYLGLYCINE, 95%, 98% EE

(R)-N-BOC-Propargylglycine, 98% ee

(R)-N-BOC-Propargylglycine(R)-N-tert-Butoxycarbonyl-2-amino-4-pentynoic acid

(R)-N-TERT-BUTOXYCARBONYL-2-AMINO-4-PENTYNOIC

Boc-D-Propargylglycine ,98%

Boc-D-Propargylglycine Boc-D-Propargylglycine

Boc-D-propraglycine

(R)-2-Boc-AMino-4-pentynoic acid

Boc-(R)-2-Propargylglycine

Boc-D-Propargyl-Gly-OH

2-[[4-[(2-methylpropan-2-yl)oxy]-4-oxobut-2-ynyl]amino]acetic acid

(2R)-2-{[(tert-butoxy)carbonyl]amino}pent-4-ynoic acid

D-2-Propargylglycine, N-BOC protected 97%

BOC-D-PROPARGYLGLYCINE

(R)-N-(TERT-BUTOXYCARBONYL)-PROPARGYLGLYCINE

(R)-N-TERT-BUTOXYCARBONYL-2-AMINO-4-PENTYNOIC ACID

(R)-N-BOC-PROPARGYLGLYCINE

RARECHEM BK PT 0259

Boc-D-Gly(propargyl)-OH

(R)-N-boc-Propargylglycine(e.e.)

N-TERT-BUTOXYCARBONYL-D-PROPARGYL GLYCINE

N-BOC-2-PROPARGYL-D-GLYCINE

BOC-2-PROPARGYL-D-GLYCINOL

D-2-Propargylglycine, N-BOC protected

(Tert-Butoxy)Carbonyl D-Pra-OH

Boc-D-Pra-OH Boc-D-Propargylglycine

4-Pentynoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, (2R)-

N-Boc-2-propargyl-D-glycine,95%

(R)-N-BOC-Propargylglycine USP/EP/BP

(R)-N-Boc-2-propargyl-glycine

N-Boc-D-Propargylglycine

(R)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid - [B90819]

63039-46-3

Unusual amino acids

Amino Acids

Amino Acid Derivatives