SPIROBIINDANE

Product Name: SPIROBIINDANE
CAS No.: 1568-80-5
Chemical Name: SPIROBIINDANE
Synonyms: SPIROBIINDANE;HIV-1 integrase inhibitor 8;TIANFU-CHEM CAS NO.1568-80-5 SPIROBIINDANE;3,3,3',3'-Tetramethyl-1,1'-spirobi[indan]-6,6'-diol;tetrahydrotetramethyl-1,1'-spirobi-1H-indene-6,6'-diol;6,6'-Dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindan;6,6'-Dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindane;3,3,3',3'-Tetramethyl-1,1'-spirobi(indan)-6,6'-diol 96%;3,3,3',3'-TETRAMETHYL-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBI[INDENE]-6,;3,3,3',3'-Tetramethyl-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-6,6'-diol
CBNumber: CB01405899
Molecular Formula: C21H24O2
Formula Weight: 308.41
MOL File: 1568-80-5.mol

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SPIROBIINDANE Property

Melting point:: 213-214 °C
Boiling point:: 478.5±45.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (405.30 mM; Need ultrasonic)
pka: 9.98±0.60(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1S/C21H24O2/c1-19(2)11-21(17-9-13(22)5-7-15(17)19)12-20(3,4)16-8-6-14(23)10-18(16)21/h5-10,22-23H,11-12H2,1-4H3
InChIKey: SICLLPHPVFCNTJ-UHFFFAOYSA-N
SMILES: C12(C3=C(C=CC(O)=C3)C(C)(C)C1)C1=C(C=CC(O)=C1)C(C)(C)C2
CAS DataBase Reference: 1568-80-5
EPA Substance Registry System: 1,1'-Spirobi[1H-indene]-6,6'-diol, 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl- (1568-80-5)

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Safety

Toxicity: rat,LD50,oral,> 5gm/kg (5000mg/kg),BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),International Journal of Toxicology. Vol. 19, Pg. 366, 2000.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P391Collect spillage. Hazardous to the aquatic environment

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: T4124
Product name: 3,3,3',3'-Tetramethyl-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-6,6'-diol
Packaging: 1G
Price: $63
Updated: 2025/07/31

TCI Chemical

Product number: T4124
Product name: 3,3,3',3'-Tetramethyl-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-6,6'-diol
Packaging: 5G
Price: $189
Updated: 2025/07/31

AK Scientific

Product number: J96903
Product name: Spirobiindane
Packaging: 100mg
Price: $40
Updated: 2021/12/16

AK Scientific

Product number: Y1348
Product name: Spirobiindane
Packaging: 100mg
Price: $52
Updated: 2021/12/16

ChemScene

Product number: CS-0028610
Product name: HIV-1integraseinhibitor8
Packaging: 100mg
Price: $81
Updated: 2021/12/16

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SPIROBIINDANE Chemical Properties,Usage,Production

Uses

HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8[1].

Hazard

Low toxicity by ingestion and skin contact. A mild eye irritant.

Synthesis

80-05-7

1568-80-5

To the reaction flask, 100 g of bisphenol A and 500 mL of methanesulfonic acid were added and stirred until completely dissolved to form a dark red solution. The reaction was continuously stirred at room temperature for 96 hours. Upon completion of the reaction, the reaction solution was slowly poured into 600 mL of ice water, cooled to room temperature and diafiltrated. The collected solid was washed well with deionized water. The washed solid was dissolved in ethanol and hot water at 50 °C under reflux conditions. Subsequently, methanol was added dropwise to the solution until no solids were precipitated, and the solution was immediately thermofiltered. The filter cake was washed several times with hot water and finally the product was dried under suitable conditions to give 45 g of a nearly white flocculent solid, 3,3,3',3'-tetramethyl-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-6,6'-diol (MSPINOL), in more than 99% yield.

References

[1] Molteni, et al. A New Class of HIV-1 Integrase Inhibitors: The 3,3,3', 3'-tetramethyl-1,1'-spirobi(indan)-5,5',6,6'-tetrol Family.J Med Chem DOI:10.1021/jm990600c

SPIROBIINDANE Preparation Products And Raw materials

Raw materials

Preparation Products

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SPIROBIINDANE Suppliers

China 93 India 1 United States 6 Global 100

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 0431-0431-80514535 19917294565
Email: et@chemextension.com
Country: China
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Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
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Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
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Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
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Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-87396432
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Country: China
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Shanghai HuanChuan Industry Co.,Ltd.

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Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Credit Asia Chemical Co., Ltd.

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Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
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Alfa Chemistry

Tel: 1-516-6625404
Fax: 1-516-927-0118
Email: support@alfa-chemistry.com
Country: United States
ProdList: 9171
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Shanghai Chiral bio-compound co., Ltd.

Tel: 021-5068 3667/17749785980/1029026415; 17749785980
Fax: 021-50683667
Email: 1029026415@qq.com
Country: China
ProdList: 3397
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Yancheng KangdiSen Pharmaceutical Co., Ltd.

Tel: 13812573443
Fax: -
Email: tongbenwan22@163.com
Country: China
ProdList: 1980
Advantage: 55

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View Lastest Price from SPIROBIINDANE manufacturers

Hebei Xinsheng New Material Technology Co., LTD.

Product: SPIROBIINDANE 1568-80-5
Price: US $35.00-25.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 Ton
Release date: 2023-11-02

Career Henan Chemical Co

Product: 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl-1,1'-Spirobi(1H-indene)-6,6'-diol 1568-80-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

1568-80-5, SPIROBIINDANERelated Search:

Chlorotrimethylsilane 2-Methylpropanedioic acid p-Toluic acid SPIROBIINDANE 5-INDANOL 1-PHENYL-1,3,3-TRIMETHYLINDAN 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDAN-5,5',6,6',7,7'-HEXOL 3,3,3',3'-TETRAMETHYL-5,5',6,6'-TETRAPROPOXY-1,1'-SPIROBIINDANE 5,5',6,6'-TETRAHYDROXY-3,3,3',3'-TETRAMETHYL-1,1'-SPIROBISINDANE

SPIROBIINDANE

2,2'',3,3''-TETRAHYDRO-3,3,3'',3''-TETRAMETHYL-1,1''-SPIROBI-1H-INDENE- 6,6''-DIOL

tetrahydrotetramethyl-1,1'-spirobi-1H-indene-6,6'-diol

3,3,3',3'-Tetramethyl-1,1'-spirobi[indan]-6,6'-diol

3,3,3',3'-Tetramethyl-2,2',3,3'-tetrahydro[1,1'-spirobi[1H-indene]]-6,6'-diol

3,3,3',3'-Tetramethyl-2,2',3,3'-tetrahydro-1,1'-spirobi[1H-indene]-6,6'-diol

6,6'-Dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindan

6,6'-Dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindane

3,3,3',3'-TETRAMETHYL-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBI[INDENE]-6,

1,1'-Spirobi[1H-indene]-6,6'-diol,2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl-

HIV-1 integrase inhibitor 8

TIANFU-CHEM CAS NO.1568-80-5 SPIROBIINDANE

3,3,3',3'-Tetramethyl-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-6,6'-diol

2,2',3,3'-Tetrahydro-3,3,3',3'-tetramethyl-1,1'-spirobi[1H-indene]-6,6'-diol

3,3,3',3'-Tetramethyl-1,1'-spirobi(indan)-6,6'-diol 96%

1568-80-5