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SPIROBIINDANE

Product Name
SPIROBIINDANE
CAS No.
1568-80-5
Chemical Name
SPIROBIINDANE
Synonyms
SPIROBIINDANE;HIV-1 integrase inhibitor 8;TIANFU-CHEM CAS NO.1568-80-5 SPIROBIINDANE;3,3,3',3'-Tetramethyl-1,1'-spirobi[indan]-6,6'-diol;tetrahydrotetramethyl-1,1'-spirobi-1H-indene-6,6'-diol;6,6'-Dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindan;6,6'-Dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindane;3,3,3',3'-Tetramethyl-1,1'-spirobi(indan)-6,6'-diol 96%;3,3,3',3'-TETRAMETHYL-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBI[INDENE]-6,;3,3,3',3'-Tetramethyl-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-6,6'-diol
CBNumber
CB01405899
Molecular Formula
C21H24O2
Formula Weight
308.41
MOL File
1568-80-5.mol
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SPIROBIINDANE Property

Melting point:
213-214 °C
Boiling point:
478.5±45.0 °C(Predicted)
Density 
1.21±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 125 mg/mL (405.30 mM; Need ultrasonic)
pka
9.98±0.60(Predicted)
form 
Solid
color 
White to off-white
InChI
InChI=1S/C21H24O2/c1-19(2)11-21(17-9-13(22)5-7-15(17)19)12-20(3,4)16-8-6-14(23)10-18(16)21/h5-10,22-23H,11-12H2,1-4H3
InChIKey
SICLLPHPVFCNTJ-UHFFFAOYSA-N
SMILES
C12(C3=C(C=CC(O)=C3)C(C)(C)C1)C1=C(C=CC(O)=C1)C(C)(C)C2
CAS DataBase Reference
1568-80-5
EPA Substance Registry System
1,1'-Spirobi[1H-indene]-6,6'-diol, 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl- (1568-80-5)
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Safety

Toxicity
rat,LD50,oral,> 5gm/kg (5000mg/kg),BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),International Journal of Toxicology. Vol. 19, Pg. 366, 2000.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P391Collect spillage. Hazardous to the aquatic environment

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
T4124
Product name
3,3,3',3'-Tetramethyl-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-6,6'-diol
Packaging
1G
Price
$63
Updated
2025/07/31
TCI Chemical
Product number
T4124
Product name
3,3,3',3'-Tetramethyl-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-6,6'-diol
Packaging
5G
Price
$189
Updated
2025/07/31
ChemScene
Product number
CS-0028610
Product name
HIV-1integraseinhibitor8
Packaging
1g
Price
$269
Updated
2021/12/16
ChemScene
Product number
CS-0028610
Product name
HIV-1integraseinhibitor8
Packaging
100mg
Price
$81
Updated
2021/12/16
ChemScene
Product number
CS-0028610
Product name
HIV-1integraseinhibitor8
Packaging
250mg
Price
$135
Updated
2021/12/16
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SPIROBIINDANE Chemical Properties,Usage,Production

Uses

HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8[1].

Hazard

Low toxicity by ingestion and skin contact. A mild eye irritant.

Synthesis

80-05-7

1568-80-5

To the reaction flask, 100 g of bisphenol A and 500 mL of methanesulfonic acid were added and stirred until completely dissolved to form a dark red solution. The reaction was continuously stirred at room temperature for 96 hours. Upon completion of the reaction, the reaction solution was slowly poured into 600 mL of ice water, cooled to room temperature and diafiltrated. The collected solid was washed well with deionized water. The washed solid was dissolved in ethanol and hot water at 50 °C under reflux conditions. Subsequently, methanol was added dropwise to the solution until no solids were precipitated, and the solution was immediately thermofiltered. The filter cake was washed several times with hot water and finally the product was dried under suitable conditions to give 45 g of a nearly white flocculent solid, 3,3,3',3'-tetramethyl-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-6,6'-diol (MSPINOL), in more than 99% yield.

References

[1] Molteni, et al. A New Class of HIV-1 Integrase Inhibitors: The 3,3,3', 3'-tetramethyl-1,1'-spirobi(indan)-5,5',6,6'-tetrol Family.J Med Chem DOI:10.1021/jm990600c

SPIROBIINDANE Preparation Products And Raw materials

Raw materials

Preparation Products

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SPIROBIINDANE Suppliers

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View Lastest Price from SPIROBIINDANE manufacturers

Hebei Xinsheng New Material Technology Co., LTD.
Product
SPIROBIINDANE 1568-80-5
Price
US $35.00-25.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 Ton
Release date
2023-11-02
Career Henan Chemical Co
Product
2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl-1,1'-Spirobi(1H-indene)-6,6'-diol 1568-80-5
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-01

1568-80-5, SPIROBIINDANERelated Search:

Chlorotrimethylsilane 2-Methylpropanedioic acid p-Toluic acid SPIROBIINDANE 5-INDANOL 1-PHENYL-1,3,3-TRIMETHYLINDAN 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDAN-5,5',6,6',7,7'-HEXOL 3,3,3',3'-TETRAMETHYL-5,5',6,6'-TETRAPROPOXY-1,1'-SPIROBIINDANE 5,5',6,6'-TETRAHYDROXY-3,3,3',3'-TETRAMETHYL-1,1'-SPIROBISINDANE

  • SPIROBIINDANE
  • 2,2'',3,3''-TETRAHYDRO-3,3,3'',3''-TETRAMETHYL-1,1''-SPIROBI-1H-INDENE- 6,6''-DIOL
  • tetrahydrotetramethyl-1,1'-spirobi-1H-indene-6,6'-diol
  • 3,3,3',3'-Tetramethyl-1,1'-spirobi[indan]-6,6'-diol
  • 3,3,3',3'-Tetramethyl-2,2',3,3'-tetrahydro[1,1'-spirobi[1H-indene]]-6,6'-diol
  • 3,3,3',3'-Tetramethyl-2,2',3,3'-tetrahydro-1,1'-spirobi[1H-indene]-6,6'-diol
  • 6,6'-Dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindan
  • 6,6'-Dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindane
  • 3,3,3',3'-TETRAMETHYL-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBI[INDENE]-6,
  • 1,1'-Spirobi[1H-indene]-6,6'-diol,2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl-
  • HIV-1 integrase inhibitor 8
  • TIANFU-CHEM CAS NO.1568-80-5 SPIROBIINDANE
  • 3,3,3',3'-Tetramethyl-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-6,6'-diol
  • 2,2',3,3'-Tetrahydro-3,3,3',3'-tetramethyl-1,1'-spirobi[1H-indene]-6,6'-diol
  • 3,3,3',3'-Tetramethyl-1,1'-spirobi(indan)-6,6'-diol 96%
  • 1568-80-5