ChemicalBook > CAS DataBase List > 5-chloropyrazine-2-carboxamide

5-chloropyrazine-2-carboxamide

Product Name
5-chloropyrazine-2-carboxamide
CAS No.
21279-64-1
Chemical Name
5-chloropyrazine-2-carboxamide
Synonyms
EOS-61239;5-Chloro-2-pyrazinecarboxamide;5-chloropyrazine-2-carboxamide;2-Pyrazinecarboxamide, 5-chloro-
CBNumber
CB01456503
Molecular Formula
C5H4ClN3O
Formula Weight
157.56
MOL File
21279-64-1.mol
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5-chloropyrazine-2-carboxamide Property

Melting point:
171-172 °C
Boiling point:
331.3±42.0 °C(Predicted)
Density 
1.478±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
13.62±0.50(Predicted)
Appearance
Off-white to yellow Powder
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B405198
Product name
5-Chloropyrazine-2-carboxamide
Packaging
10mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
W4430
Product name
5-Chloropyrazine-2-carboxamide
Packaging
5g
Price
$335
Updated
2021/12/16
AK Scientific
Product number
W4430
Product name
5-Chloropyrazine-2-carboxamide
Packaging
10g
Price
$533
Updated
2021/12/16
Matrix Scientific
Product number
073264
Product name
5-Chloropyrazine-2-carboxamide
Purity
95+%
Packaging
1g
Price
$559
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0055147
Product name
5-CHLOROPYRAZINE-2-CARBOXAMIDE
Purity
95.00%
Packaging
1G
Price
$1289.14
Updated
2021/12/16
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5-chloropyrazine-2-carboxamide Chemical Properties,Usage,Production

Synthesis

33332-25-1

21279-64-1

General procedure for the synthesis of 5-chloropyrazine-2-carboxamide from methyl 5-chloropyrazine-2-carboxylate: Step 1: Ammonium chloride (558 mg, 10.4 mmol) was suspended in benzene (5 mL), and a toluene solution of 2M trimethylaluminum (5.2 mL, 10.4 mmol) was added slowly and dropwise at 0 °C. After stirring for 1 h, a solution of methyl 5-chloropyrazine-2-carboxylate (600 mg, 3.48 mmol) in benzene (5 mL) was added. The reaction mixture was heated to 50 °C and stirred overnight. After the reaction was completed and cooled to room temperature, the reaction mixture was poured into water and neutralized with saturated aqueous sodium bicarbonate. The mixture was extracted with ethyl acetate and the organic layer was washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol = 100:0 → 98:2) to afford 5-chloropyrazine-2-carboxamide (236 mg, 43% yield) as a white solid.

References

[1] Patent: WO2009/145360, 2009, A1. Location in patent: Page/Page column 71
[2] Patent: EP2123651, 2009, A1. Location in patent: Page/Page column 21

5-chloropyrazine-2-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-chloropyrazine-2-carboxamide manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
5-chloropyrazine-2-carboxamide 21279-64-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
5-chloropyrazine-2-carboxamide 21279-64-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
5-chloropyrazine-2-carboxamide 21279-64-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2019-07-03

21279-64-1, 5-chloropyrazine-2-carboxamideRelated Search:

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  • 21279-64-1