5-chloropyrazine-2-carboxamide
- Product Name
- 5-chloropyrazine-2-carboxamide
- CAS No.
- 21279-64-1
- Chemical Name
- 5-chloropyrazine-2-carboxamide
- Synonyms
- EOS-61239;5-Chloro-2-pyrazinecarboxamide;5-chloropyrazine-2-carboxamide;2-Pyrazinecarboxamide, 5-chloro-
- CBNumber
- CB01456503
- Molecular Formula
- C5H4ClN3O
- Formula Weight
- 157.56
- MOL File
- 21279-64-1.mol
5-chloropyrazine-2-carboxamide Property
- Melting point:
- 171-172 °C
- Boiling point:
- 331.3±42.0 °C(Predicted)
- Density
- 1.478±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 13.62±0.50(Predicted)
- Appearance
- Off-white to yellow Powder
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B405198
- Product name
- 5-Chloropyrazine-2-carboxamide
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- W4430
- Product name
- 5-Chloropyrazine-2-carboxamide
- Packaging
- 5g
- Price
- $335
- Updated
- 2021/12/16
- Product number
- W4430
- Product name
- 5-Chloropyrazine-2-carboxamide
- Packaging
- 10g
- Price
- $533
- Updated
- 2021/12/16
- Product number
- 073264
- Product name
- 5-Chloropyrazine-2-carboxamide
- Purity
- 95+%
- Packaging
- 1g
- Price
- $559
- Updated
- 2021/12/16
- Product number
- HCH0055147
- Product name
- 5-CHLOROPYRAZINE-2-CARBOXAMIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1289.14
- Updated
- 2021/12/16
5-chloropyrazine-2-carboxamide Chemical Properties,Usage,Production
Synthesis
33332-25-1
21279-64-1
General procedure for the synthesis of 5-chloropyrazine-2-carboxamide from methyl 5-chloropyrazine-2-carboxylate: Step 1: Ammonium chloride (558 mg, 10.4 mmol) was suspended in benzene (5 mL), and a toluene solution of 2M trimethylaluminum (5.2 mL, 10.4 mmol) was added slowly and dropwise at 0 °C. After stirring for 1 h, a solution of methyl 5-chloropyrazine-2-carboxylate (600 mg, 3.48 mmol) in benzene (5 mL) was added. The reaction mixture was heated to 50 °C and stirred overnight. After the reaction was completed and cooled to room temperature, the reaction mixture was poured into water and neutralized with saturated aqueous sodium bicarbonate. The mixture was extracted with ethyl acetate and the organic layer was washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol = 100:0 → 98:2) to afford 5-chloropyrazine-2-carboxamide (236 mg, 43% yield) as a white solid.
References
[1] Patent: WO2009/145360, 2009, A1. Location in patent: Page/Page column 71
[2] Patent: EP2123651, 2009, A1. Location in patent: Page/Page column 21
5-chloropyrazine-2-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
5-chloropyrazine-2-carboxamide Suppliers
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
View Lastest Price from 5-chloropyrazine-2-carboxamide manufacturers
- Product
- 5-chloropyrazine-2-carboxamide 21279-64-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 5-chloropyrazine-2-carboxamide 21279-64-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 5-chloropyrazine-2-carboxamide 21279-64-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-03