Ibudilast

Product Name: Ibudilast
CAS No.: 50847-11-5
Chemical Name: Ibudilast
Synonyms: Ketas;KC-404;AV 411;MN-166;CS-351;Pinatos;Eyevinal;budilast;IBUDILAST;lbudilast
CBNumber: CB0145945
Molecular Formula: C14H18N2O
Formula Weight: 230.31
MOL File: 50847-11-5.mol

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Ibudilast Property

Melting point:: 53-54°C
Boiling point:: 175°C/7.5mmHg(lit.)
Density: 1.09
refractive index: 1.5500 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: 28 mg/mL, soluble
form: solid
pka: 1.22±0.30(Predicted)
color: white
Merck: 14,4879
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI: InChI=1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3
InChIKey: ZJVFLBOZORBYFE-UHFFFAOYSA-N
SMILES: C(C1=C2N(N=C1C(C)C)C=CC=C2)(=O)C(C)C
CAS DataBase Reference: 50847-11-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: UR0711200
HS Code: 2933.99.8290
Toxicity: LD50 i.v. in mice: 260 mg/kg (Irikura, 1973)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I0157
Product name: Ibudilast
Purity: ≥99% (HPLC), solid
Packaging: 10mg
Price: $313
Updated: 2024/03/01

Sigma-Aldrich

Product number: I0157
Product name: Ibudilast
Purity: ≥99% (HPLC), solid
Packaging: 50mg
Price: $1190
Updated: 2024/03/01

TCI Chemical

Product number: I0740
Product name: Ibudilast
Purity: >98.0%(HPLC)(T)
Packaging: 20mg
Price: $40
Updated: 2024/03/01

TCI Chemical

Product number: I0740
Product name: Ibudilast
Purity: >98.0%(HPLC)(T)
Packaging: 100mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 14832
Product name: Ibudilast
Purity: ≥98%
Packaging: 5mg
Price: $44
Updated: 2024/03/01

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Ibudilast Chemical Properties,Usage,Production

Description

Ibudilast is a leukomene antagonist and phosphodiesterase inhibitor useful in the treatment of bronchial asthma. It antagonizes leukotriene D4-induced contractions of guinea pig ileum and tracheal muscles in virro, and inhibits eosinophil accumulation in vivo.

Chemical Properties

White Solid

Originator

Kyorin (Japan)

Uses

a phosphodiesterase inhibitor with anti-inflammatory activity

Uses

Inhibitors of phosphodiesterase 4 (PDE4), which catalyzes the hydrolysis of cAMP, have potential applications in a variety of diseases, including asthma. Ibudilast is an inhibitor of PDE4 (IC50 = 54-239 nM) that, at higher doses, also inhibits PDE3 and PDE5 (IC50 = 1,600-3,510 nM). Through this action, it suppresses the elaboration of mediators involved in asthma and inflammation.[Cayman Chemical]

Uses

A leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral)

Definition

ChEBI: Ibudilast is a pyrazolopyridine.

brand name

Ketas

Biological Activity

Phosphodiesterase inhibitor (IC 50 values are 53, 35, 48, 12 and 10 mM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.

Biochem/physiol Actions

Phosphodiesterase IV (PDE4) inhbitor. Inhibits platelet aggregation. Anti-asthma drug.

in vitro

ibudilast could potently inhibit purified human pde4a, 4b, 4c and 4d with ic50 values at 54, 65, 239 and 166 nm, respectively. ibudilast was also able to effectively block lps-induced tumor necrosis factor and n-formyl-metleu-phe-induced leukotriene b4 biosynthesis in human whole blood [1].

in vivo

rats received a daily oral administration of 10, 30 or 60 mg/kg ibudilast. results showed that in the vehicle-treated animals, white matter lesions and microglial activation occurred in the optic tract, internal capsule and corpus callosum. a low dose of ibudilast failed to suppress the white matter lesions and microglial activation, whereas a dose of either 30 or 60 mg/kg ibudilast ameliorated these lesions [2].

IC 50

54-239 nm

storage

Store at RT

References

1) Kishi et al. (2001), Ibudilast: a non-selective PDE inhibitor with multiple actions on blood cells and the vascular wall; Cardiovasc. Drug Rev., 19 215 2) Yamazaki et al. (2011), Ibudilast. A mixed PDE3/4 inhibitor, causes a selective and nitric oxide/cGMP-independent relaxation of the intracranial vertebrobasilar artery; Eur. J. Pharmacol., 650 605 3) Cueva Vargas et al. (2016), The glial cell modulator ibudilast attenuates neuroinflammation and enhances retinal ganglion cell viability in glaucoma through protein kinase A signaling.; Neurobiol. Dis., 93 156 4) Mizuno et al. (2004), Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia; Neuropharmacology, 46 404 5) Ledeboer et al. (2007), Ibudilast (AV-411). A class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes; Expert. Opin. Investig. Drugs, 16 935

Ibudilast Preparation Products And Raw materials

Raw materials

Sodium acetate 2-Picoline Isobutyric anhydride

Preparation Products

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Ibudilast Suppliers

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View Lastest Price from Ibudilast manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.

Product: Ibudilast 50847-11-5
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99% HPLC
Supply Ability: 10000
Release date: 2024-09-17

Dorne Chemical Technology co. LTD

Product: Ibudilast 50847-11-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2024-03-26

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Ibudilast 50847-11-5
Price: US $0.00/Kg/Bag
Min. Order: 100g
Purity: 99%min
Supply Ability: 50kg
Release date: 2021-10-25

50847-11-5, IbudilastRelated Search:

Methyl acrylate Isobutyryl chloride Naphazoline hydrochloride METHYL THIOPHENE-2-CARBOXYLATE Isobutyraldehyde Bensulfuron methyl Citric acid monohydrate Kresoxim-methyl Thiophanate-methyl ULINASTATIN Cefazolin 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Methylparaben Cilastatin Imipenem-Cilastatin sodium hydrate Isobutyric anhydride Isobutyric acid Pyridine

IBUDILAST

IBUDILAST-D7

KC-404

1-PROPANONE, 2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]

3-Isobutyryl-2-isopropy-lpyrazolo[1，5-α]pyridine

Ketas

Eyevinal

1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methyl-1-propanone

Pinatos

Ibudilast,2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone, 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404

1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-Methylpropan-1-one

AV 411

Ibudilast (KC-404)

MN-166

CS-351

-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone

3-ISOBUTYRYL-2-ISOPROPYLPYRAZOLO(1,5-A)PYRIDINE

2-isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine

2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]-1-PROPANONE

Ibudilast 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine

2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one

Ibudilast, >=98%

budilast

1-propanone 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine KC-404

2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]

3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404, 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone

2-methyl-1-(2-(1-methylethyl)pyrazolo(1,5-a)pyridin-3-yl)-1-propanon

5-a)pyridine,3-isobutyryl-2-isopropyl-pyrazolo(

lbudilast

2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone, 3-isobutyrl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404, Ketas

2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-α]pyridin-3-yl]-1-propanone, 3-isobutyrl-2-isopropylpyrazolo[1,5-α]pyridine, KC-404, Ketas

Ibudilast&gt

Ibudilast USP/EP/BP

Ibudilast (KC404, AV411， MN166)

IbudilastQ: What is Ibudilast Q: What is the CAS Number of Ibudilast Q: What is the storage condition of Ibudilast Q: What are the applications of Ibudilast

50847-11-5

BioChemical

Cell Signaling and Neuroscience

Cell Biology

G Proteins and Cyclic Nucleotides

Phosphodiesterase Inhibitors

Cyclic Nucleotide Metabolism

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Cyclic Nucleotide related

Amines

Heterocycles

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