Desvenlafaxine succinate

Product Name: Desvenlafaxine succinate
CAS No.: 386750-22-7
Chemical Name: Desvenlafaxine succinate
Synonyms: Pristiq;Unii-zb22enf0xr;WY 45233 succinate;Desvenla succinate;Desvenlafaxine succinate;Norvenlafaxine succinate;Pristiq succinate hydrate;C16H25NO2.HOOCCH2CH2COOH.H2O;Desvenlafaxine (succinate hydrate);Desvenlafaxine succinate USP/EP/BP
CBNumber: CB01459766
Molecular Formula: C20H31NO6
Formula Weight: 381.47
MOL File: 386750-22-7.mol

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Desvenlafaxine succinate Property

storage temp.: Store at +4°C
solubility: DMSO:3.0(Max Conc. mg/mL);7.51(Max Conc. mM)
form: Powder
color: White to off-white
Stability:: Hygroscopic
InChI: InChI=1S/C16H25NO2.C4H6O4/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16;5-3(6)1-2-4(7)8/h6-9,15,18-19H,3-5,10-12H2,1-2H3;1-2H2,(H,5,6)(H,7,8)
InChIKey: ORUUBRMVQCKYHB-UHFFFAOYSA-N
SMILES: C(C(=O)O)CC(=O)O.C(C1C=CC(O)=CC=1)(C1(CCCCC1)O)CN(C)C

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Safety

HS Code: 2922504500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29855
Product name: Desvenlafaxine (succinate hydrate)
Packaging: 50mg
Price: $84
Updated: 2024/03/01

Cayman Chemical

Product number: 29855
Product name: Desvenlafaxine (succinate hydrate)
Packaging: 1g
Price: $765
Updated: 2024/03/01

Cayman Chemical

Product number: 29855
Product name: Desvenlafaxine (succinate hydrate)
Packaging: 25mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 29855
Product name: Desvenlafaxine (succinate hydrate)
Packaging: 100mg
Price: $145
Updated: 2024/03/01

Biosynth Carbosynth

Product number: FD139136
Product name: 4-(2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol succinate monohydrate
Packaging: 100mg
Price: $260
Updated: 2021/12/16

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Desvenlafaxine succinate Chemical Properties,Usage,Production

Description

Desvenlafaxine Succinate is a dual serotonin and norepinephrine reuptake inhibitor (SNRI) that was approved for the treatment of major depressive disorder (MDD) in the United States in 2008. In order to improve the efficacy and safety profile of venlafaxine, Wyeth discovered and developed one of the major metabolites of venlafaxine, namely the O-desmethyl metabolite (desvenlafaxine). Desvenlafaxine is also being developed for the treatment of moderate to severe vasomotor symptoms associated with menopause (i.e., hot flashes and night sweats) and is also in phase III clinical trials to study it’s effectiveness in treating fibromyalgia and neuropathic pain.

Chemical Properties

Desvenlafaxine succinate (Pristiq SR) is an extended-release tablet for oral administration that contains desvenlafaxine succinate, a structurally novel SNRI for treating MDD. Desvenlafaxine succinate is a white to off-white powder that is soluble in water. The solubility of Desvenlafaxine succinate is pH-dependent. Its octanol: aqueous system (at pH 7.0) partition coefficient is 0.21. Desvenlafaxine succinate (Pristiq SR) is available as a 50 mg extended-release tablet for oral administration. The 50 mg tablet consists of light pink, square (pyramid, one-sided), film-coated tablets debossed “W” over “50” on the flat side.

Uses

Antianxiety therapeutic

Synthesis

Desvenlafaxine has been prepared via two different routes, and both are described in the scheme. The first route involved simple demethylation of venlafaxine (67) using L-selectride in dimethoxyethane giving desvenlafaxine 68 as its free base in 91% yield. Compound 68 was then recrystallized with succinic acid in acetone/ water to give desvenlafaxine succinate (VIII) in 86% yield. An alternative method to prepare desvenlafaxine is described in the bottom portion of the scheme. 4-Benzyloxyphenylacetic acid 69 was converted to its corresponding acid chloride upon treatment with thionyl chloride and catalytic DMF in refluxing methylene chloride. The crude reaction mixture was added to a solution of dimethylamine hydrochloride and triethyl amine in methylene chloride at 5 ??C to give dimethylacetamide 70 in 90% yield. Deprotonation of 70 with LHMDS in THF at -70 ??C followed by addition of cyclohexanone gave alcohol 71 in 82% yield. Reduction of the acetamide with borane THF complex in refluxing THF produced dimethyl amine 72 in 66% yield. Catalytic hydrogenation in the presence of 20% Pd/C effected debenzylation of 72 to give desvenlafaxine free base 68 in 87% yield.

Desvenlafaxine succinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Desvenlafaxine succinate Suppliers

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View Lastest Price from Desvenlafaxine succinate manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Desvenlafaxine Succinate 386750-22-7
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-09-06

Career Henan Chemical Co

Product: Desvenlafaxine succinate 386750-22-7
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10KG
Release date: 2018-07-25

386750-22-7, Desvenlafaxine succinateRelated Search:

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Desvenlafaxine succinate

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Desvenlafaxine succinate monohydrate

Pristiq

Unii-zb22enf0xr

Desvenlafaxine (succinate hydrate)

C16H25NO2.HOOCCH2CH2COOH.H2O

4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenolsuccinate

WY 45233 succinate

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Desvenlafaxine (O-DesMethyl Venlafaxine) Succinate Monohydrate

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Desvenla succinate

O-Desmethylvenlafaxine succinate hydrate

Pristiq succinate hydrate

PRISTIQ SUCCINATE HYDRATE;O-DESMETHYLVENLAFAXINE SUCCINATE HYDRATE

Desvenlafaxine succinic acid monohydrate

[2H6]-rac-O-Desmethyl Venlafaxine Succinate Hydrate

Desvenlafaxine succinate USP/EP/BP

RAC-O-DESMETHYL VENLAFAXINE-D6 SUCCINATE HYDRATE

Desvenlafaxine succinateQ: What is Desvenlafaxine succinate Q: What is the CAS Number of Desvenlafaxine succinate Q: What is the storage condition of Desvenlafaxine succinate Q: What are the applications of Desvenlafaxine succinate

TIANFUCHEM-- Desvenlafaxine succinate

Desvenlafaxine Succinate (1-[2-(Dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclohexanol hydrogen butanedioate monohydrate) (1175773)

Desvenlafaxine Succinate Monohydrate (O-Desmethylvenlafaxine Succinate Monohydrate)

Norvenlafaxine succinate

386750-22-7

00-00-3

C20H33NO7

C16H25NO2C4H6O4

C16H25NO2C4H6O4H2O

Inhibitors

APIs