ChemicalBook > CAS DataBase List > Canrenone

Canrenone

Product Name
Canrenone
CAS No.
976-71-6
Chemical Name
Canrenone
Synonyms
CANRENONE-D4;sc9376;11614r.p;RP-11614;CANRENONE;phanurane;kanlitong;ALDADIENE;NSC 261713;Canrenone CRS
CBNumber
CB0147626
Molecular Formula
C22H28O3
Formula Weight
340.46
MOL File
976-71-6.mol
More
Less

Canrenone Property

Melting point:
158-1600C
alpha 
D +24.5° (chloroform)
Boiling point:
416.25°C (rough estimate)
Density 
1.1236 (rough estimate)
refractive index 
1.5000 (estimate)
storage temp. 
room temp
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
color 
white to beige
optical activity
[α]/D +17 to +24°, c = 1 in chloroform-d
Water Solubility 
272.4ug/L(25 ºC)
InChI
InChI=1/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/s3
InChIKey
UJVLDDZCTMKXJK-MUWITHSMNA-N
SMILES
[C@@]12(CCC(=O)O1)CC[C@@]1([H])[C@]3([H])C=CC4=CC(=O)CC[C@]4(C)[C@@]3([H])CC[C@]21C |&1:0,8,10,20,22,26,r|
LogP
2.54 at 25℃
CAS DataBase Reference
976-71-6
NIST Chemistry Reference
Canrenone(976-71-6)
More
Less

Safety

Hazard Codes 
Xn,N
Risk Statements 
40-51/53
Safety Statements 
36/37-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
HS Code 
29329990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H351Suspected of causing cancer

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1497
Product name
Canrenone
Purity
≥97% (HPLC)
Packaging
50mg
Price
$80.7
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2887
Product name
Spironolactone Related Compound A
Purity
pharmaceutical secondary standard, certified reference material
Packaging
150MG
Price
$344
Updated
2024/03/01
Sigma-Aldrich
Product number
1619017
Product name
Spironolactone Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
100mg
Price
$1490
Updated
2024/03/01
Alfa Aesar
Product number
J60238
Product name
Canrenone, 98%
Packaging
1g
Price
$59.65
Updated
2024/03/01
Alfa Aesar
Product number
J60238
Product name
Canrenone, 98%
Packaging
5g
Price
$187.65
Updated
2024/03/01
More
Less

Canrenone Chemical Properties,Usage,Production

Chemical Properties

Pale yellow to pale Green Solid

Originator

Spiroctan,Boehringer Mannheim,Switz.,1968

Uses

Aldosterone antagonist. Diuretic

Uses

antiinflammatory, glucocorticoid

Uses

Inhibits aldosterone biosynthesis and blocks ouabain effects

Definition

ChEBI: Canrenone is a steroid lactone.

Manufacturing Process

The lactone is prepared as follows: A solution of 5 parts of 17α-carboxyethyl- 17β-hydroxyandrost-4-en-3-one lactone and 5 parts of chloranil in 400 parts of xylene containing a trace of p-toluenesulfonic acid is heated at the boiling point of the solvent under reflux overnight. The solution is then cooled and filtered through approximately 200 parts of silica gel. The gel is successively washed with 5%, 10%, and 15% ethyl acetate-benzene solutions, and the washings comprising 15% ethyl acetate are thereupon purified by chromatography on a further quantity of silica gel, using benzene and ethyl acetate as developing solvents. From the 15% ethyl acetate eluate there is obtained pure 17α-carboxyethyl-17β-hydroxyandrost-4,6-dien-3-one lactone, melting at 148° to 151°C. The product solidifies above this melting point and melts again at 165°C.

brand name

Luvion.

Therapeutic Function

Aldosterone antagonist, Diuretic

World Health Organization (WHO)

Canrenone, which has aldosterone antagonist activity, is a major metabolite of spironolactone and the major metabolite of potassium canrenoate. See WHO comments for potassium canrenoate and spironolactone.

Flammability and Explosibility

Non flammable

Biological Activity

Mineralocorticoid receptor antagonist. Active metabolite of spironolactone ((7a,17a)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid g-lactone ).

Biochem/physiol Actions

Canrenone is a mineralocorticoid (aldosterone) inhibitor.

Canrenone Preparation Products And Raw materials

Raw materials

Potassium Propionate Androstenediol Iodomethane

Preparation Products

More
Less

Canrenone Suppliers

Canada 3 China 204 France 1 Germany 3 India 8 Spain 2 United Kingdom 9 United States 26 Venezuela 1 Global 257
Hubei Qibu New Material Technology Co., Ltd.
Tel
0715-8890696 18062324989 18062324989
Email
2284979616@qq.com
Country
China
ProdList
519
Advantage
58
HuBei ShengBaoLai Biological Technology Co., Ltd
Tel
027-027-59105235 13007105135
Fax
027-59105235
Email
sbl1120@163.com
Country
China
ProdList
107
Advantage
55
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2341
Advantage
56
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8849
Advantage
52
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11714
Advantage
57
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9664
Advantage
60
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5654
Advantage
65
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18216
Advantage
56
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81960175
Fax
+1-541-2553641
Email
min.he@cato-chem.com
Country
China
ProdList
1958
Advantage
55
Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488 18007166089
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
2024
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17982
Advantage
56
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4951
Advantage
58
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9911
Advantage
50
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8147
Advantage
55
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9767
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80
Nanjing XiZe Biotechnology CO., Ltd.
Tel
025-58362220 15250997978
Fax
025-58362220
Email
1511893459@qq.com
Country
China
ProdList
7715
Advantage
55
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
551-65418679 15837135945
Fax
0551-65418697
Email
info@tnjchem.com
Country
China
ProdList
1889
Advantage
62
Jinan Putubio Tech Co., Ltd.
Tel
+86 (531) 8099-2215
Fax
+86 (531) 8099-2215
Email
putubio@outlook.com
Country
China
ProdList
1261
Advantage
55
Hangzhou Dingyan Chem Co., LTD
Tel
0571-0571-87157530-8001-8003 18008611859
Fax
0571-87156470
Email
sales@dingyanchem.com
Country
China
ProdList
1997
Advantage
58
Henan CoreyChem Co., Ltd
Tel
0371-86658258
Fax
0371-60996044
Email
info@coreychem.com
Country
China
ProdList
10457
Advantage
58
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9604
Advantage
55
Lancrix Chemicals
Tel
86-21-50817262
Fax
86-21-57712035
Email
sales@lancrix.com
Country
China
ProdList
1503
Advantage
55
Cangzhou Enke Pharma-tech Co., Ltd.
Tel
0317-5296180 15533709196
Fax
0317-5106596
Email
sale@enkepharma.com
Country
China
ProdList
1649
Advantage
55
Raw material medicin reagent co.,Ltd
Tel
025-57798860
Email
sales@njromanme.com
Country
China
ProdList
4534
Advantage
58
Tonichem Pharmaceutical Technology Co., Ltd.
Tel
+86 (0752) 222-7171, +86 15815821171
Fax
+86 (0752) 222-6171
Country
China
ProdList
1120
Advantage
58
WG reagent
Tel
13391486464
Fax
QQ:14748090
Email
samwjf@163.com
Country
China
ProdList
3090
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58
Wellman Pharmaceutical Group Limited
Tel
027-027-83778875 15807197853
Fax
027-83991220
Email
15807197853@163.com
Country
China
ProdList
3979
Advantage
58
Taian Jiaye Biotechnology Co.Ltd
Tel
13127280945
Email
285424065@qq.com
Country
China
ProdList
9980
Advantage
55
Guangzhou Jhd Chemical Reagent Co., Ltd.
Tel
020-84383047
Fax
020-84380294
Email
sales@jhd.com.cn
Country
China
ProdList
9190
Advantage
65
Shenzhen SUNGENING Bio-Medical Co., Ltd.
Tel
0755-28967200 13631290199
Fax
0755-28967200
Email
wxf@sungening.com
Country
China
ProdList
9506
Advantage
60
Shanghai Orgchem Co.,Ltd.
Tel
+86-21-5877 1921
Fax
+86-21-5877 1925
Email
info@chemofchina.com
Country
China
ProdList
9661
Advantage
55
Wuhan Zonvsicom chemicals Co.,Ltd.
Tel
15623071665
Fax
027-59257948
Email
sales@zvsicom.com
Country
China
ProdList
299
Advantage
58
Wuhan Netcom Electronic Commerce Limited
Tel
18064670521
Fax
0757-88210752
Email
2355935187@ycphar.com
Country
China
ProdList
4887
Advantage
58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17997
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
24971
Advantage
58
Wuhan Zeno Biological Technology Co., Ltd.
Tel
13657284589
Fax
027-87781970
Email
znobio@qq.com
Country
China
ProdList
141
Advantage
58
Rixing Chemical CO.,LTD.
Tel
13237129059
Fax
-
Email
info@rixingchemi.com
Country
China
ProdList
233
Advantage
58
Jida Pharmaceutical Chemicals (Shanghai) Co., Ltd.
Tel
021-56383663,17717680878
Fax
021-56383663
Email
jidapharm@126.com
Country
CHINA
ProdList
125
Advantage
58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10305
Advantage
58
Nanjing crow LuNing pharmaceutical technology co., LTD
Tel
13382066392
Country
CHINA
ProdList
4880
Advantage
58
Shaanxi billion Kang Long biological technology co., LTD
Tel
17791478691
Fax
4009024560
Email
yklbiotech@163.com
Country
China
ProdList
409
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
400-400-400-9004166 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52712
Advantage
58
Beijing OKA biological technology co., LTD
Tel
010-62971590 18548936886
Fax
010-62340519
Email
3462612863@qq.com
Country
China
ProdList
6912
Advantage
58
More
Less

View Lastest Price from Canrenone manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
Canrenone 976-71-6
Price
US $30.00/box
Min. Order
1box
Purity
98%
Supply Ability
2000box
Release date
2024-03-21
Hebei Kangcang new material Technology Co., LTD
Product
Canrenone 976-71-6
Price
US $20.00-10.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20
Release date
2024-03-20
Hebei Kangcang new material Technology Co., LTD
Product
Canrenone 976-71-6
Price
US $9.00-60.00/g
Min. Order
10g
Purity
99%
Supply Ability
10 tons
Release date
2024-03-22

976-71-6, CanrenoneRelated Search:

11-HYDROXY-CANRENONE Coenzyme Q10 Risperidone CHLOROPHOSPHONAZO III (-)-Corey lactone diol TRIOXSALEN 11-a-Hydroxy canrenone methyl ester Delta 9,11-canrenone (7a,17a)-17-Hydroxy-3-oxo-pregna-4,9(11)-diene-7,21-dicarboxylicacid g-lactone methyl ester 6-B-HYDROXY EPLERENONE Eplerenone EP Impurity B SC 25152 Eplerenone EP Impurity A Eplerenone 7-Carboxylic Acid Impurity Undecan-4-olide DIHYDROTERPINYL ACETATE gamma-Octanoic lactone Dihydrojasmone lactone

  • phanurane
  • pregna-4,6-diene-21-carboxylicacid,17-hydroxy-3-oxo-,gamma-lactone,(17-alph
  • sc9376
  • spirolactonesc14266
  • CANRENOIC ACID GAMMA LACTONE
  • CANRENONE
  • CANRENONE-D4
  • 4,6-ANDROSTADIEN[(17(B-1')-SPIRO-5')]-PERHYDROFURAN-2,3-DIONE
  • 4,6-ANDROSTEN-17-ALPHA-YL-PROPIONIOACID-R-LACTONE
  • PREGNA-4,6-DIENE-17-BETA-0L-3-ONE-21-CARBOXYLIC ACID-GAMMA LACTONE
  • 7-Carboxy-9(11)&Delta
  • kanlitong
  • Spironolactone Impurity 6（Spironolactone EP Impurity F）
  • 11614r.p
  • 17-(2-Carboxyethyl)17-hydroxy-3-oxoandrosta-4,6-dienelactone
  • 17-(2-Carboxyethyl)17-hydroxyandrosta-4,6-dien-3-onelactone
  • 17-hydroxy-3-oxo-,gamma-lactone,(17-alpha)-pregna-6-diene-21-carboxylicacid
  • 17-Hydroxy-3-oxo-17-pregna-4,6-diene-21-carboxylicacid-lactone
  • ALDADIENE
  • 17-hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylic acid gamma-lactone
  • CANRENONE[SPIRONOLACTONE INTERMEDIATE]
  • Canrenone98.5%Min
  • 17a-(2-Carboxyethyl-17b-hydroxyandrosta-4,6-dien-3-one Lactone
  • (7a)-17-Hydroxy-3-oxo-pregna-4,6-diene-21-carboxylic Acid g-Lactone
  • ((7 )-17-Hydroxy-3-oxo-pregna-4,6-diene-21-carboxylic Acid -Lactone)
  • (7a)-17-Hydroxy-3-oxo-pregna-4,6-diene-21-carboxylic Acid -Lactone
  • 17a-2-Carboxyethyl-17-hydroxyandrosta-4,6-dien-3-one Lactone
  • Spironolactone EP Impurity F
  • Journal of risperidone
  • Canrenone, >=97%
  • Eplerenone Impurity 28
  • (17R)-17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid γ-lactone
  • (17R)-3-Oxo-17-hydroxypregna-4,6-diene-21-carboxylic acid γ-lactone
  • (17α)-17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylicacidγ-lactone
  • Spironolactone Related Compound A (100 mg) (Canrenone (3-Oxo-17-alpha-pregna-4,6-diene-21, 17-carbolactone)) (AS)
  • Eplerenone IMpurity - Canrenone
  • (8R,9S,10R,13S,14S,17R)-10,13-dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione
  • Spironolactone Related CoMpound A
  • Pregna-4,6-diene-21-carboxylicacid, 17-hydroxy-3-oxo-, g-lactone, (17a)-
  • Canrenone 17-hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylic acid gamma-lactone
  • NSC 261713
  • 10,13-Dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione
  • Canrenone Solution, 100ppm
  • Eplerenone Canrenone Impurity
  • Canrenone CRS
  • 6,7-Dehydro-7α-desthioacetylspironolactone
  • RP-11614
  • Spironolactone EP Impurity F-d4 (Canrenone-d4)
  • Spironolactone EP Impurity F (Canrenone)
  • Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, γ-lactone, (17α)-
  • 7-Carboxy-9(11)Δ-canrenone
  • Spiranolactone Impurity F
  • Canrenone D7Q: What is Canrenone D7 Q: What is the CAS Number of Canrenone D7 Q: What is the storage condition of Canrenone D7 Q: What are the applications of Canrenone D7
  • CanrenoneQ: What is Canrenone Q: What is the CAS Number of Canrenone Q: What is the storage condition of Canrenone Q: What are the applications of Canrenone
  • Spironolactone Related Compound A (Canrenone (3-Oxo-17-alpha-pregna-4,6-diene-21, 17-carbolactone)) (1619017)
  • Candy, ketone
  • 6,7-Dehydro-7α-desthioacetylspironolactone
  • Spironolactone USP Related Compound A