4-Aminotetrahydro-2H-thiopyran 1,1-dioxide hydrochloride
- Product Name
- 4-Aminotetrahydro-2H-thiopyran 1,1-dioxide hydrochloride
- CAS No.
- 116529-31-8
- Chemical Name
- 4-Aminotetrahydro-2H-thiopyran 1,1-dioxide hydrochloride
- Synonyms
- 1,1-Dioxo-hexahydro-1l6-thiopyran-4-ylamine;1,1-Dioxo-tetrahydro-2H-thiopyran-4-amine HCl;4-aMino-1$l^{6}-thiane-1,1-dione hydrochloride;4-AMinotetrahydro-2H-thiopyran 1,1-dioxide HCl;4-Aminotetrahydrothiopyran 1,1-Dioxide HydrochL;1,1-dioxo-tetrahydrothiopyran-4-amine hydrochloride;4-AMinotetrahydrothiopyran 1,1-Dioxide Hydrochloride;1,1-Dioxo-tetrahydro-2H-thiopyran-4-amine hydrochloride;4-AMINOTETRAHYDRO-2H-THIOPYRAN 1,1-DIOXIDE HYDROCHLORIDE;Tetrahydro-2H-thiopyran-4-amine 1,1-dioxide hydrochloride
- CBNumber
- CB01476307
- Molecular Formula
- C5H12ClNO2S
- Formula Weight
- 185.67
- MOL File
- 116529-31-8.mol
4-Aminotetrahydro-2H-thiopyran 1,1-dioxide hydrochloride Property
- Melting point:
- 289 °C
- storage temp.
- Inert atmosphere,Room Temperature
- Water Solubility
- Soluble in water
- form
- powder to crystal
- color
- White to Almost white
- CAS DataBase Reference
- 116529-31-8
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SYX00433
- Product name
- 4-Aminotetrahydro-2H-thiopyran 1,1-dioxide hydrochloride hydrochloride
- Packaging
- 1g
- Price
- $1300
- Updated
- 2025/07/31
- Product number
- A3327
- Product name
- 4-Aminotetrahydro-2H-thiopyran 1,1-Dioxide Hydrochloride
- Packaging
- 200MG
- Price
- $46
- Updated
- 2025/07/31
- Product number
- A3327
- Product name
- 4-Aminotetrahydro-2H-thiopyran 1,1-Dioxide Hydrochloride
- Packaging
- 1G
- Price
- $134
- Updated
- 2025/07/31
- Product number
- A617730
- Product name
- 4-Aminotetrahydro-2H-thiopyran 1,1-Dioxide Hydrochloride
- Packaging
- 1g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- A617730
- Product name
- 4-Aminotetrahydro-2H-thiopyran 1,1-Dioxide Hydrochloride
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
4-Aminotetrahydro-2H-thiopyran 1,1-dioxide hydrochloride Chemical Properties,Usage,Production
Uses
4-Aminotetrahydro-2H-thiopyran 1,1-dioxide, HCl
Synthesis
595597-01-6
116529-31-8
The general procedure for the synthesis of 4-aminotetrahydro-2H-thiopyran 1,1-dioxide hydrochloride from tert-butyl (1,1-dioxidotetrahydro-2H-thiopyran-4-yl)carbamate was as follows: tert-butyl (1,1-dioxidotetrahydro-2H-thiopyran-4-yl)carbamate (3.14 g) was dissolved in ethyl acetate (110 mL) that was preheated to 50 °C, to which a solution was subsequently 4M HCl-ethyl acetate solution (30 mL) was added. The reaction mixture was stirred at room temperature for 19 hours. Upon completion of the reaction, the precipitated white crystals were collected by filtration and washed with ethyl acetate. Finally, the product was dried under reduced pressure to afford 4-aminotetrahydro-2H-thiopyran 1,1-dioxide hydrochloride (2.39 g, 100% yield). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 1.93-2.11 (2H, m), 2.23 (2H, d, J=14.4 Hz), 3.08-3.21 (2H, m), 3.21-3.46 (3H, m), 8.10 (3H, br.s.).
References
[1] Patent: EP2261213, 2010, A1. Location in patent: Page/Page column 53
[2] Patent: EP1486490, 2004, A1. Location in patent: Page 45
[3] Patent: WO2008/34860, 2008, A1. Location in patent: Page/Page column 104
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 8, p. 3548 - 3571
[5] Patent: WO2008/145688, 2008, A2. Location in patent: Page/Page column 92
4-Aminotetrahydro-2H-thiopyran 1,1-dioxide hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Aminotetrahydro-2H-thiopyran 1,1-dioxide hydrochloride manufacturers
- Product
- 4-Aminotetrahydro-2H-thiopyran 1,1-dioxide hydrochloride 116529-31-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- 4-Aminotetrahydro-2H-thiopyran 1,1-dioxide hydrochloride 116529-31-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-25