1-(2-METHOXY-5-METHYLPHENYL)ETHANONE

Product Name: 1-(2-METHOXY-5-METHYLPHENYL)ETHANONE
CAS No.: 20628-07-3
Chemical Name: 1-(2-METHOXY-5-METHYLPHENYL)ETHANONE
Synonyms: 2'-METHOXY-5'-METHYLACETOPHENONE;2’-Methoxy-5’-methylacetophenone;Ethanone, 1-(2-methoxy-5-methylphenyl)-;1-(2-methoxy-5-methylphenyl)ethan-1-one;JR-8524, 1-(2-Methoxy-5-methylphenyl)ethanone, 97%;Butanoicacid,2-amino-4-bromo-,(2S)-,hydrobromide(1:3)
CBNumber: CB01490624
Molecular Formula: C10H12O2
Formula Weight: 164.2
MOL File: 20628-07-3.mol

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1-(2-METHOXY-5-METHYLPHENYL)ETHANONE Property

Melting point:: 120.5°C
storage temp.: Sealed in dry,Room Temperature
Appearance: Light yellow to yellow Liquid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S883360
Product name: 2''-METHOXY-5''-METHYLACETOPHENONE
Purity: AldrichCPR
Packaging: 50MG
Price: $30.7
Updated: 2025/07/31

TRC

Product number: M341355
Product name: 1-(2-Methoxy-5-methylphenyl)ethanone
Packaging: 5mg
Price: $45
Updated: 2021/12/16

TRC

Product number: M341355
Product name: 1-(2-Methoxy-5-methylphenyl)ethanone
Packaging: 10mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: 2328BB
Product name: 1-(2-Methoxy-5-methylphenyl)ethanone
Packaging: 100mg
Price: $91
Updated: 2021/12/16

AK Scientific

Product number: 2328BB
Product name: 1-(2-Methoxy-5-methylphenyl)ethanone
Packaging: 1g
Price: $174
Updated: 2021/12/16

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1-(2-METHOXY-5-METHYLPHENYL)ETHANONE Chemical Properties,Usage,Production

Preparation

Preparation by reaction of acetic acid with 4-methylanisole in the presence of trifluoromethyl-sulfonic anhydride (Tf2O) for 3 min at r.t. (97%).

Synthesis

104-93-8

75-36-5

20628-07-3

General procedure for the synthesis of 1-(2-methoxy-5-methylphenyl)ethanone from p-toluene methyl ether and acetyl chloride: 1. An ethanolic solution of acetyl chloride (6.79 mL, 95.1 mmol) was slowly added dropwise to a 50 mL suspension in dichloromethane containing aluminum chloride (12.69 g, 95.1 mmol) at 0 °C. 2. Subsequently, a solution of 1-methoxy-4-methylbenzene (intermediate LXXXVII) (9.69 g, 79.4 mmol) in 50 mL of dichloromethane was slowly added dropwise to the above reaction mixture.3. After the dropwise addition was completed, the reaction mixture was stirred at room temperature for 3 h. 4. Upon completion of the reaction, the reaction was quenched with 1.5 N hydrochloric acid solution and the reaction mixture was extracted with dichloromethane.5. The organic extract was combined and washed sequentially with water and The organic extracts were combined, washed sequentially with water and brine, and then dried over anhydrous sodium sulfate.6 After evaporation of the solvent, the crude product was purified by column chromatography (silica gel 100-200 mesh, eluent ratio 15:85 ethyl acetate:hexane) to afford 1-(2-methoxy-5-methylphenyl)ethanone in 69% yield.7 The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.528 (s, 1H), 7.247 (bs, 1H), 6.852-6.873 (d, 1H, J = 8.4 Hz), 3.881 (s, 3H), 2.601 (s, 3H), 2.299 (s, 3H).

References

[1] Patent: WO2012/90219, 2012, A2. Location in patent: Page/Page column 86
[2] Chemische Berichte, 1928, vol. 61, p. 1999
[3] Vikram, 1959, vol. 3, # 1, p. 1,3

1-(2-METHOXY-5-METHYLPHENYL)ETHANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2-METHOXY-5-METHYLPHENYL)ETHANONE Suppliers

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2'-METHOXY-5'-METHYLACETOPHENONE

JR-8524, 1-(2-Methoxy-5-methylphenyl)ethanone, 97%

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Butanoicacid,2-amino-4-bromo-,(2S)-,hydrobromide(1:3)

2’-Methoxy-5’-methylacetophenone

20628-07-3