1-(2-METHOXY-5-METHYLPHENYL)ETHANONE
- Product Name
- 1-(2-METHOXY-5-METHYLPHENYL)ETHANONE
- CAS No.
- 20628-07-3
- Chemical Name
- 1-(2-METHOXY-5-METHYLPHENYL)ETHANONE
- Synonyms
- 2'-METHOXY-5'-METHYLACETOPHENONE;2’-Methoxy-5’-methylacetophenone;Ethanone, 1-(2-methoxy-5-methylphenyl)-;1-(2-methoxy-5-methylphenyl)ethan-1-one;JR-8524, 1-(2-Methoxy-5-methylphenyl)ethanone, 97%;Butanoicacid,2-amino-4-bromo-,(2S)-,hydrobromide(1:3)
- CBNumber
- CB01490624
- Molecular Formula
- C10H12O2
- Formula Weight
- 164.2
- MOL File
- 20628-07-3.mol
1-(2-METHOXY-5-METHYLPHENYL)ETHANONE Property
- Melting point:
- 120.5°C
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Light yellow to yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S883360
- Product name
- 2''-METHOXY-5''-METHYLACETOPHENONE
- Purity
- AldrichCPR
- Packaging
- 50MG
- Price
- $30.7
- Updated
- 2025/07/31
- Product number
- M341355
- Product name
- 1-(2-Methoxy-5-methylphenyl)ethanone
- Packaging
- 5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M341355
- Product name
- 1-(2-Methoxy-5-methylphenyl)ethanone
- Packaging
- 10mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 2328BB
- Product name
- 1-(2-Methoxy-5-methylphenyl)ethanone
- Packaging
- 100mg
- Price
- $91
- Updated
- 2021/12/16
- Product number
- 2328BB
- Product name
- 1-(2-Methoxy-5-methylphenyl)ethanone
- Packaging
- 1g
- Price
- $174
- Updated
- 2021/12/16
1-(2-METHOXY-5-METHYLPHENYL)ETHANONE Chemical Properties,Usage,Production
Preparation
Preparation by reaction of acetic acid with 4-methylanisole in the presence of trifluoromethyl-sulfonic anhydride (Tf2O) for 3 min at r.t. (97%).
Synthesis
104-93-8
75-36-5
20628-07-3
General procedure for the synthesis of 1-(2-methoxy-5-methylphenyl)ethanone from p-toluene methyl ether and acetyl chloride: 1. An ethanolic solution of acetyl chloride (6.79 mL, 95.1 mmol) was slowly added dropwise to a 50 mL suspension in dichloromethane containing aluminum chloride (12.69 g, 95.1 mmol) at 0 °C. 2. Subsequently, a solution of 1-methoxy-4-methylbenzene (intermediate LXXXVII) (9.69 g, 79.4 mmol) in 50 mL of dichloromethane was slowly added dropwise to the above reaction mixture.3. After the dropwise addition was completed, the reaction mixture was stirred at room temperature for 3 h. 4. Upon completion of the reaction, the reaction was quenched with 1.5 N hydrochloric acid solution and the reaction mixture was extracted with dichloromethane.5. The organic extract was combined and washed sequentially with water and The organic extracts were combined, washed sequentially with water and brine, and then dried over anhydrous sodium sulfate.6 After evaporation of the solvent, the crude product was purified by column chromatography (silica gel 100-200 mesh, eluent ratio 15:85 ethyl acetate:hexane) to afford 1-(2-methoxy-5-methylphenyl)ethanone in 69% yield.7 The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.528 (s, 1H), 7.247 (bs, 1H), 6.852-6.873 (d, 1H, J = 8.4 Hz), 3.881 (s, 3H), 2.601 (s, 3H), 2.299 (s, 3H).
References
[1] Patent: WO2012/90219, 2012, A2. Location in patent: Page/Page column 86
[2] Chemische Berichte, 1928, vol. 61, p. 1999
[3] Vikram, 1959, vol. 3, # 1, p. 1,3