5-FLUORO-2,3-DIHYDRO-(1H)-INDOLE
- Product Name
- 5-FLUORO-2,3-DIHYDRO-(1H)-INDOLE
- CAS No.
- 94805-51-3
- Chemical Name
- 5-FLUORO-2,3-DIHYDRO-(1H)-INDOLE
- Synonyms
- 2-hydroxy-4-cyanopyridine;2,3-DIHYDRO-5-FLUORO(1H)-INDOLE;2-hydroxypyridine-4-carbonitrile;1,2-dihydro-2-oxo-4-Pyridinecarbonitrile;4-Pyridinecarbonitrile, 1,2-dihydro-2-oxo-;4-Pyridinecarbonitrile,1,2-dihydro-2-oxo-(9CI);5-FLUORO-2,3-DIHYDRO-(1H)-INDOLE ISO 9001：2015 REACH
- CBNumber
- CB0149165
- Molecular Formula
- C6H4N2O
- Formula Weight
- 120.11
- MOL File
- 94805-51-3.mol
5-FLUORO-2,3-DIHYDRO-(1H)-INDOLE Property
- Melting point:
- 285-288
- Boiling point:
- 102-104°C/6.8mm
- Flash point:
- 107 °C
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Off-white to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H314Causes severe skin burns and eye damage
H332Harmful if inhaled
H341Suspected of causing genetic defects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P308+P313IF exposed or concerned: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H480550
- Product name
- 2-Hydroxyisonicotinonitrile
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- V9473
- Product name
- 4-Cyano-2(1H)-pyridinone
- Packaging
- 250mg
- Price
- $89
- Updated
- 2021/12/16
- Product number
- 009317
- Product name
- 2-Hydroxyisonicotinonitrile
- Packaging
- 1g
- Price
- $51
- Updated
- 2021/12/16
- Product number
- 4H37-1-4Q
- Product name
- 2-Hydroxyisonicotinonitrile
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 009317
- Product name
- 2-Hydroxyisonicotinonitrile
- Packaging
- 5g
- Price
- $190
- Updated
- 2021/12/16
5-FLUORO-2,3-DIHYDRO-(1H)-INDOLE Chemical Properties,Usage,Production
Synthesis
42182-27-4
94805-51-3
General procedure for the synthesis of 2-oxo-1,2-dihydropyridine-4-carbonitrile from 2-amino-4-cyanopyridine: Sodium nitrite (NaNO2, 0.99 g, 14.3 mmol) was added in batches to a well-stirred 2-amino-4-cyanopyridine (0.96 g, 8.1 mmol) dissolved in concentrated sulfuric acid (H2SO4, 1.2 mL) and water (11 mL) in a premixed solution. During the reaction, the temperature of the reaction mixture was maintained between 0-5 °C and strictly controlled in the range of 5 ± 5 °C. With the release of nitrogen (N2), the originally clarified solution gradually became turbid. The mixture was slowly warmed to room temperature with stirring, followed by reflux heating in a water bath for 30 min and finally cooled to room temperature. The solid product formed was collected by filtration, washed with water (H2O) and dried under vacuum to afford the target product 2-oxo-1,2-dihydropyridine-4-carbonitrile (0.9 g, 92% yield) as a colorless solid. The structure of the product was confirmed by 1H NMR (DMSO-d6): δ 8.21 (d, 1H, J = 2.4 Hz), 7.61 (dd, 1H, J = 2.4, 9.6 Hz), 6.38 (d, 1H, J = 9.6 Hz), 3.3 (broad peak, 1H + 2H2O).
References
[1] Patent: WO2014/63199, 2014, A1. Location in patent: Page/Page column 59
5-FLUORO-2,3-DIHYDRO-(1H)-INDOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-FLUORO-2,3-DIHYDRO-(1H)-INDOLE manufacturers
- Product
- 5-FLUORO-2,3-DIHYDRO-(1H)-INDOLE 94805-51-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25