ChemicalBook > CAS DataBase List > Prostratin, PKC activator

Prostratin, PKC activator

Product Name: Prostratin, PKC activator
CAS No.: 60857-08-1
Chemical Name: Prostratin, PKC activator
Synonyms: SA 101A;NSC 623310;CCRIS 6292;PROSTRATIN;Prostatin >99%;Stillingia Facto;Prostratin[P0077];13-O-Acetylphorbol;Prostratin, PKC activator;12-DEOXYPHORBOL 13-ACETATE
CBNumber: CB0150130
Molecular Formula: C22H30O6
Formula Weight: 390.47
MOL File: 60857-08-1.mol

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Prostratin, PKC activator Property

Melting point:: 216-219℃
Boiling point:: 550.5±50.0 °C(Predicted)
Density: 1.31
storage temp.: -20°C
solubility: Soluble in DMSO at 30mg/ml
form: white powder
pka: 11.40±0.70(Predicted)
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Safety

WGK Germany: 3
HS Code: 2916200090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P0077
Product name: Prostratin
Purity: ≥98% (HPLC)
Packaging: 1mg
Price: $124.45
Updated: 2025/07/31

Sigma-Aldrich

Product number: P0077
Product name: Prostratin
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $501.6
Updated: 2025/07/31

Cayman Chemical

Product number: 10272
Product name: Prostratin
Purity: ≥98%
Packaging: 500μg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 10272
Product name: Prostratin
Purity: ≥98%
Packaging: 1mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 10272
Product name: Prostratin
Packaging: 5mg
Price: $435
Updated: 2024/03/01

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Prostratin, PKC activator Chemical Properties,Usage,Production

Description

Activation of latent reservoirs of HIV-infected cells is a treatment strategy designed to reduce viral load and eliminate the perpetuation of retroviral infection. Prostratin is a non-tumor promoting phorbol ester that potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells with an IC₅₀ value of ~0.5 μM. Originally, prostratin was isolated from plant sources including P. prostrata, E. cornigera, and H. nutans. The effects of prostratin are mediated through activation of NF-κB via protein kinase C and by downregulation of HIV-1 receptor CD4 expression and its co-receptors CXCR4 and CCR5.

Uses

Definition

ChEBI: A natural product found in Euphorbia fischeriana.

Biochem/physiol Actions

Prostratin, an unusual non-tumorigenic phorbol ester, is an activator of protein kinase C (PKC) and also an activator of nuclear factor KB (NF-KB) mediated through activation of the IKKs (IKB kinases). Prostratin exhibits potent in vitro activity by inducing HIV expression in latently infected cell lines and primary cells, thus antagonizing HIV latency. Activation of PKC and NF-kB has been proposed as the mechanism of action. Prostratin also inhibits HIV entry into target cells by down-regulating CD4 and CXCR4 receptors.

IC 50

PKC: 12.5 nM (Ki); HIV-1

References

[1] A.R. CASHMORE ∗ . The structure of prostratin : a toxic tetracyclic diterpene ester from Pimelea Prostrata[J]. Tetrahedron Letters, 1976, 17 20: Pages 1737-1738. DOI:10.1016/s0040-4039(00)92940-x
[2] GHULAM ABBAS MIANA. Prostratin: An Overview.[J]. Mini reviews in medicinal chemistry, 2015, 15 13: 1122-1130. DOI:10.2174/1389557515666150511154108
[3] XING SHEN . The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents[J]. Cancer letters, 2015, 356 2: Pages 686-696. DOI:10.1016/j.canlet.2014.10.018
[4] ANGÉLIQUE BIANCOTTO. Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue.[J]. Journal of Virology, 2004, 78 19: 10507-10515. DOI:10.1128/jvi.78.19.10507-10515.2004
[5] NOELIA GERIBALDI-DOLDÁN. 12-Deoxyphorbols Promote Adult Neurogenesis by Inducing Neural Progenitor Cell Proliferation via PKC Activation.[J]. International Journal of Neuropsychopharmacology, 2015, 19 1. DOI:10.1093/ijnp/pyv085

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View Lastest Price from Prostratin, PKC activator manufacturers

Henan Bao Enluo International TradeCo.，LTD

Product: Prostratin 60857-08-1
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500t/month
Release date: 2023-08-03

Career Henan Chemical Co

Product: Prostratin, PKC activator 60857-08-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-18

Career Henan Chemical Co

Product: Prostratin, PKC activator 60857-08-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-18

60857-08-1, Prostratin, PKC activatorRelated Search:

PHORBOL 12-MYRISTATE 13-ACETATE Prostratin, PKC activator NS-398 H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH PHORBOL 12,13-DIBUTYRATE 3H-PMA PHORBOL 12,13-DIACETATE PHORBOL 12,13-DIDECANOATE PHORBOL 13-ACETATE PHORBOL-12,13-DIHEXANOATE PHORBOL 12,13,20-TRIACETATE, 4BETA PHORBOL 12-MYRISTATE 13-ACETATE 4-O-METHYL ETHER, 4BETA PHORBOL 12-N-METHYLANTHRANILATE PHORBOL 16-HYDROXY 12-PALMITATE 13-ACETATE 3H-PDBU 3H-PDA PHORBOL 13,20-DIACETATE PHORBOL-13-DECANOATE

SA 101A

Prostatin >99%

12-Deoxyphorbol 13-Acetate, dPAc

(1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a -decahydro-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-

13-O-Acetyl-12-deoxyphorbol

PROSTRATIN

(1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a -decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl- 5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one

13-O-Acetylphorbol

NSC 623310

Stillingia Facto

CCRIS 6292

12-DEOXYPHORBOL 13-ACETATE

(1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aβ,7bα-dihydroxy-9aα-acetoxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benzo[1,2-e]azulene-5-one

(1aR)-9aα-Acetoxy-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aβ,7bα-dihydroxy-3-hydroxymethyl-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one

Prostratin, PKC activator

5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one, 9a-(acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-, (1aR,1bS,4aR,7aS,7bR,8R,9aS)-

Prostratin, PKC activator USP/EP/BP

(1aR,1bS,4aR,7aS,7bR,8R,9aS)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9a-yl acetate

Prostratin[P0077]

60857-08-1

Activator

Chiral Reagents

Intermediates & Fine Chemicals

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Protein Kinase Inhibitors and Activators