PHORBOL 12,13-DIACETATE Property

Boiling point:

477.23°C (rough estimate)

Density 

1.1793 (rough estimate)

refractive index 

1.4480 (estimate)

storage temp. 

−20°C

solubility 

H2O: soluble

form 

powder

color 

white

BRN 

2317312

Safety

Hazard Codes 

T+

Risk Statements 

26/27/28-36/37/38

Safety Statements 

26-27-36/37/39-45

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

GZ0651000

F 

8-10

HazardClass 

6.1(a)

PackingGroup 

II

HS Code 

2915290000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

PHORBOL 12,13-DIACETATE Chemical Properties,Usage,Production

Uses

Phorbol 12,13-diacetate may be used to stimulate protein kinase C (PKC) for phosphorylation of retinal proteins.

General Description

Phorbol ester with enhanced hydrophilicity.

Biochem/physiol Actions

Phorbol 12,13-diacetate (PDA) serves as a protein kinase C (PKC). It induces arrest in translocation in rod photoreceptors. PDA facilitates PKC in regulating airway contractility by inducing transient relaxation after a sustained contraction of the human isolated bronchus. PDA improves the synaptic transmission of nociceptive parabrachioamygdaloid (PBA) input onto neurons of the capsular central amygdaloid (CeAC) nucleus via activating PKC and extracellular-regulated kinase (ERK).