PHORBOL 12,13-DIBUTYRATE

Product Name: PHORBOL 12,13-DIBUTYRATE
CAS No.: 37558-16-0
Chemical Name: PHORBOL 12,13-DIBUTYRATE
Synonyms: PDBU;C03634;Phorbol 12;13-dibutyrate;PHORBOL 12,13-DIBUTYRATE;Phorbol 12,13-dibutanoate;Phorbol 12,13-Dibutyrate >99%;PHORBOL 12,13-DIBUTYRATE, 4BETA;Phorbol 12,13dibutyrate,Phorbol 12,13 dibutyrate;Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem
CBNumber: CB5117703
Molecular Formula: C28H40O8
Formula Weight: 504.61
MOL File: 37558-16-0.mol

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PHORBOL 12,13-DIBUTYRATE Property

Boiling point:: 513.95°C (rough estimate)
Density: 1.1270 (rough estimate)
refractive index: 1.4480 (estimate)
storage temp.: -20°C
solubility: H₂O: 30 μM
form: powder
pka: 11.15±0.70(Predicted)
color: clear, light yellow, film
BRN: 6551234
CAS DataBase Reference: 37558-16-0(CAS DataBase Reference)
EPA Substance Registry System: Phorbol 12,13-dibutyrate (37558-16-0)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
RIDADR: 2928
WGK Germany: 3
RTECS: EK7767000
F: 8-10
HazardClass: 6.1(a)
PackingGroup: II
HS Code: 2915601990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H351Suspected of causing cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 524390
Product name: Phorbol-12,13-dibutyrate
Packaging: 1mg
Price: $99.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 524390
Product name: Phorbol-12,13-dibutyrate
Packaging: 5mg
Price: $289
Updated: 2024/03/01

Cayman Chemical

Product number: 27785
Product name: Phorbol 12,13-dibutyrate
Packaging: 1mg
Price: $79
Updated: 2024/03/01

Cayman Chemical

Product number: 27785
Product name: Phorbol 12,13-dibutyrate
Packaging: 5mg
Price: $254
Updated: 2024/03/01

Sigma-Aldrich

Product number: P1269
Product name: Phorbol 12,13-dibutyrate
Purity: ≥98% (TLC), powder
Packaging: 1mg
Price: $107
Updated: 2024/03/01

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PHORBOL 12,13-DIBUTYRATE Chemical Properties,Usage,Production

Uses

Phorbol 12,13-dibutyrate has been used as a protein kinase C (PKC) activator to study its effects on human organic anion transporter 4 (hOAT4) activity. It has also been used as a PKC activator to analyze its effects on galectin-3 expression and matrix production in HL-1 cells.

Definition

ChEBI: Phorbol 12,13-dibutanoate is a phorbol ester, a butyrate ester and a tertiary alpha-hydroxy ketone.

General Description

White solid.

Reactivity Profile

PHORBOL 12,13-DIBUTYRATE may be sensitive to prolonged exposure to air, light and ambient temperatures. PHORBOL 12,13-DIBUTYRATE may also be subject to autooxidation.

Fire Hazard

The flash point of PHORBOL 12,13-DIBUTYRATE has not been determined, but PHORBOL 12,13-DIBUTYRATE is probably combustible.

Biological Activity

phorbol 12,13-dibutyrate, a phorbol ester, is an activator of pkc, including the conventional calcium-dependent subtypes (α and γ), the nonconventional calcium-independent isoforms (δ, ε, η), as well as the atypical calcium-independent and dag or phorbol ester-unresponsive subtype (ζ). pkc plays an important role in the regulation of a variety of cellular processes such as exocytosis, gene expression, cell proliferation and differentiation, as well as tumor promotion, thereby representing the major target for tumor-promoting phorbol esters and chemically unrelated tumor promoters. phorbol esters are able to replace the endogenous activator dag in the stimulation of pkc, and participate in the multistage process of tumor formation and progression.1. geiges d, meyer t, marte b, et al. activation of protein kinase c subtypes alpha, gamma, delta, epsilon, zeta, and eta by tumor-promoting and nontumor-promoting agents. biochemical pharmacology, 1997, 53(6): 865-875.2. middleton jp, khan wa, collinsworth g, et al. heterogeneity of protein kinase c-mediated rapid regulation of na/k-atpase in kidney epithelial cells. journal of biological chemistry, 1993, 268(21): 15958-15964.3. scribner jd, boutwell rk. inflammation and tumor promotion: selective protein induction in mouse skin by tumor promoters. european journal of cancer, 1972, 8(6): 617-621.

Biochem/physiol Actions

Phorbol 12,13-dibutyrate (PDBu) is a potent activator of protein kinase C (PKC). It is more hydrophilic than phorbol 12-myristate 13-acetate (PMA), which facilitates washing PDBu out of cells in tissue culture. PDBu activates endothelial nitric oxide synthase expression in primary human umbilical vein endothelial cells, which in turn correlates with PKC α and ε expression.

storage

Store at -20°C

PHORBOL 12,13-DIBUTYRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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PHORBOL 12,13-DIBUTYRATE Suppliers

China 38 Germany 1 Japan 3 Switzerland 3 United Kingdom 5 United States 19 USA 1 Global 70

J & K SCIENTIFIC LTD.

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View Lastest Price from PHORBOL 12,13-DIBUTYRATE manufacturers

Career Henan Chemica Co

Product: PHORBOL 12,13-DIBUTYRATE 37558-16-0
Price: US $0.37/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg/100kg
Release date: 2020-11-09

37558-16-0, PHORBOL 12,13-DIBUTYRATERelated Search:

1,2-DIOCTANOYL-SN-GLYCEROL Prostratin, PKC activator 1-OLEOYL-2-ACETYL-SN-GLYCEROL PHORBOL 12-MYRISTATE 13-ACETATE (-)-INDOLACTAM V INGENOL 3,20-DIBENZOATE (+)-7-OCTYLINDOLACTAM V FTT PHORBOL PDNHV PHORBOL 12,13-DIDECANOATE 4A-PHORBOL 12,13-DIBUTYRATE, 99+%,4ALPHA-PHORBOL 12,13-DIBUTYRATE PHORBOL-12,13-DIHEXANOATE PHORBOL 12,13-DIBUTYRATE PDDHV 4-BETA-PHORBOL-12,13-DIBUTYRATE 4Α-PHORBOL 12,13-DIBUTYRATE PHORBOL-12,13-DIBUTYRATE, [20-3H(N)]

butanoicacid,1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymet

hyl)-1,1,6,8-tetramethyl-5-oxo-9ah-cyclopropa(3,4)benz(1,2-e)azulene-9,9a-diy

lester,(1ar-(1a-alpha,1b-beta,4a-beta,7a-alpha,7b-alpha,8-alpha,9-beta,9a-al

PDBU

PHORBOL 12,13-DIBUTYRATE

PHORBOL 12,13-DIBUTYRATE, 4BETA

(1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aβ,7bα-dihydroxy-3-hydroxymethyl-1,1,6,8α-tetramethyl-5-oxo-5H-cyclopropa[3,4]benz[1,2-e]azulene-9β,9aα-diol 9,9a-dibutyrate

9β,9aα-Bis(butyryloxy)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aβ,7bα-dihydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one

(1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-5-oxo-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulene-4aα,7bα,9β,9aα-tetrol 9,9a-dibutyrate

C03634

Phorbol 12,13-dibutanoate

(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1a,1b,4,4a,5,7a,7b,8,9,9a-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9,9a-diylbutanoicacidester

Phorbol 12,13-Dibutyrate >99%

(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulene-9,9a-diyl dibutyrate

Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem

Butanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl ester

13-dibutyrate

Phorbol 12

Phorbol 12,13dibutyrate,Phorbol 12,13 dibutyrate

37558-16-0

C28H40O8

Kinase/Phosphatase Biology

Protein Kinase C (PKC)

Serine/Threonine Kinase Activators

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Activator