PHORBOL 12,13-DIBUTYRATE
- Product Name
- PHORBOL 12,13-DIBUTYRATE
- CAS No.
- 37558-16-0
- Chemical Name
- PHORBOL 12,13-DIBUTYRATE
- Synonyms
- PDBU;C03634;Phorbol 12;13-dibutyrate;PHORBOL 12,13-DIBUTYRATE;Phorbol 12,13-dibutanoate;Phorbol 12,13-Dibutyrate >99%;PHORBOL 12,13-DIBUTYRATE, 4BETA;Phorbol 12,13dibutyrate,Phorbol 12,13 dibutyrate;Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem
- CBNumber
- CB5117703
- Molecular Formula
- C28H40O8
- Formula Weight
- 504.61
- MOL File
- 37558-16-0.mol
PHORBOL 12,13-DIBUTYRATE Property
- Boiling point:
- 513.95°C (rough estimate)
- Density
- 1.1270 (rough estimate)
- refractive index
- 1.4480 (estimate)
- storage temp.
- -20°C
- solubility
- H2O: 30 μM
- form
- powder
- pka
- 11.15±0.70(Predicted)
- color
- clear, light yellow, film
- Water Solubility
- H2O: 30μM
DMSO: soluble
acetone: soluble
ethanol: soluble - BRN
- 6551234
- CAS DataBase Reference
- 37558-16-0(CAS DataBase Reference)
- EPA Substance Registry System
- Phorbol 12,13-dibutyrate (37558-16-0)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H317May cause an allergic skin reaction
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H351Suspected of causing cancer
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 524390
- Product name
- Phorbol-12,13-dibutyrate
- Packaging
- 1mg
- Price
- $99.4
- Updated
- 2024/03/01
- Product number
- 524390
- Product name
- Phorbol-12,13-dibutyrate
- Packaging
- 5mg
- Price
- $289
- Updated
- 2024/03/01
- Product number
- 27785
- Product name
- Phorbol 12,13-dibutyrate
- Packaging
- 1mg
- Price
- $79
- Updated
- 2024/03/01
- Product number
- 27785
- Product name
- Phorbol 12,13-dibutyrate
- Packaging
- 5mg
- Price
- $254
- Updated
- 2024/03/01
- Product number
- P1269
- Product name
- Phorbol 12,13-dibutyrate
- Purity
- ≥98% (TLC), powder
- Packaging
- 1mg
- Price
- $107
- Updated
- 2024/03/01
PHORBOL 12,13-DIBUTYRATE Chemical Properties,Usage,Production
Uses
Phorbol 12,13-dibutyrate has been used as a protein kinase C (PKC) activator to study its effects on human organic anion transporter 4 (hOAT4) activity. It has also been used as a PKC activator to analyze its effects on galectin-3 expression and matrix production in HL-1 cells.
Definition
ChEBI: Phorbol 12,13-dibutanoate is a phorbol ester, a butyrate ester and a tertiary alpha-hydroxy ketone.
General Description
White solid.
Reactivity Profile
PHORBOL 12,13-DIBUTYRATE may be sensitive to prolonged exposure to air, light and ambient temperatures. PHORBOL 12,13-DIBUTYRATE may also be subject to autooxidation.
Fire Hazard
The flash point of PHORBOL 12,13-DIBUTYRATE has not been determined, but PHORBOL 12,13-DIBUTYRATE is probably combustible.
Biological Activity
phorbol 12,13-dibutyrate, a phorbol ester, is an activator of pkc, including the conventional calcium-dependent subtypes (α and γ), the nonconventional calcium-independent isoforms (δ, ε, η), as well as the atypical calcium-independent and dag or phorbol ester-unresponsive subtype (ζ). pkc plays an important role in the regulation of a variety of cellular processes such as exocytosis, gene expression, cell proliferation and differentiation, as well as tumor promotion, thereby representing the major target for tumor-promoting phorbol esters and chemically unrelated tumor promoters. phorbol esters are able to replace the endogenous activator dag in the stimulation of pkc, and participate in the multistage process of tumor formation and progression.1. geiges d, meyer t, marte b, et al. activation of protein kinase c subtypes alpha, gamma, delta, epsilon, zeta, and eta by tumor-promoting and nontumor-promoting agents. biochemical pharmacology, 1997, 53(6): 865-875.2. middleton jp, khan wa, collinsworth g, et al. heterogeneity of protein kinase c-mediated rapid regulation of na/k-atpase in kidney epithelial cells. journal of biological chemistry, 1993, 268(21): 15958-15964.3. scribner jd, boutwell rk. inflammation and tumor promotion: selective protein induction in mouse skin by tumor promoters. european journal of cancer, 1972, 8(6): 617-621.
Biochem/physiol Actions
Phorbol 12,13-dibutyrate (PDBu) is a potent activator of protein kinase C (PKC). It is more hydrophilic than phorbol 12-myristate 13-acetate (PMA), which facilitates washing PDBu out of cells in tissue culture. PDBu activates endothelial nitric oxide synthase expression in primary human umbilical vein endothelial cells, which in turn correlates with PKC α and ε expression.
storage
Store at -20°C
PHORBOL 12,13-DIBUTYRATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PHORBOL 12,13-DIBUTYRATE manufacturers
- Product
- PHORBOL 12,13-DIBUTYRATE 37558-16-0
- Price
- US $0.37/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10kg/100kg
- Release date
- 2020-11-09