ChemicalBook > CAS DataBase List > 2-BROMO-5-HYDROXYMETHYL-ANISOLE

2-BROMO-5-HYDROXYMETHYL-ANISOLE

Product Name
2-BROMO-5-HYDROXYMETHYL-ANISOLE
CAS No.
17100-64-0
Chemical Name
2-BROMO-5-HYDROXYMETHYL-ANISOLE
Synonyms
(4-broMo-3-Methoxyphenyl)Methanol;4-Bromo-3-methoxybenzyl alcohol;2-BROMO-5-HYDROXYMETHYL-ANISOLE;Benzyl alcohol, 4-bromo-3-methoxy-;Benzenemethanol, 4-bromo-3-methoxy-
CBNumber
CB01519637
Molecular Formula
C8H9BrO2
Formula Weight
217.06
MOL File
17100-64-0.mol
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2-BROMO-5-HYDROXYMETHYL-ANISOLE Property

Boiling point:
306.8±27.0 °C(Predicted)
Density 
1.513±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
14.04±0.10(Predicted)
form 
solid
color 
Faint orange/brown
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Safety

HS Code 
2909498090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AstaTech
Product number
63215
Product name
2-BROMO-5-HYDROXYMETHYL-ANISOLE
Purity
97%
Packaging
1G
Price
$63
Updated
2026/04/30
AstaTech
Product number
63215
Product name
2-BROMO-5-HYDROXYMETHYL-ANISOLE
Purity
97%
Packaging
5G
Price
$237
Updated
2026/04/30
AstaTech
Product number
63215
Product name
2-BROMO-5-HYDROXYMETHYL-ANISOLE
Purity
97%
Packaging
25G
Price
$889
Updated
2026/04/30
Matrix Scientific
Product number
126935
Product name
(4-Bromo-3-methoxyphenyl)methanol
Packaging
1.00g
Price
$396
Updated
2026/05/18
Matrix Scientific
Product number
126935
Product name
(4-Bromo-3-methoxyphenyl)methanol
Packaging
5.00g
Price
$1224
Updated
2026/05/18
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2-BROMO-5-HYDROXYMETHYL-ANISOLE Chemical Properties,Usage,Production

Synthesis

6971-51-3

17100-64-0

The general procedure for the synthesis of 2-bromo-5-hydroxymethyl anisole from m-methoxybenzyl alcohol was as follows: to a solution of 3-methoxybenzyl alcohol (20.0 g, 145 mmol) in tetrahydrofuran (THF, 400 mL) was added N-bromosuccinimide (NBS, 26 g, 146 mmol). The reaction mixture was stirred at room temperature for 8 hours. After the reaction was completed, ether (500 mL) was added to dilute and the mixture was washed with deionized water (3 x 100 mL). The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford 2-bromo-5-hydroxymethyl anisole (31.2 g, 99% yield), and the product was used directly in the next reaction without further purification.

References

[1] Patent: US9725406, 2017, B1. Location in patent: Page/Page column 7-8
[2] Tetrahedron, 2005, vol. 61, # 49, p. 11692 - 11696
[3] Patent: US2018/208604, 2018, A1. Location in patent: Paragraph 0201-0203
[4] Patent: US2010/4159, 2010, A1. Location in patent: Page/Page column 59; 64
[5] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 3, p. 1010 - 1014

2-BROMO-5-HYDROXYMETHYL-ANISOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMO-5-HYDROXYMETHYL-ANISOLE Suppliers

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