ChemicalBook > CAS DataBase List > Donepezil

Donepezil

Product Name
Donepezil
CAS No.
120014-06-4
Chemical Name
Donepezil
Synonyms
5,6-Dimethoxy-2,3-dihydro-1H-inden-1-one;Donepenil;Donezepil;2-((1-Benzylpiperidin-4-yl)Methyl)-5,6-diMethoxy-2,3-dihydro-1H-inden-1-one;Donepezilo;N-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl] piperidine;2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-1h-inde;n-1-one;onepezil;HSDB7743
CBNumber
CB0156314
Molecular Formula
C24H29NO3
Formula Weight
379.49
MOL File
120014-06-4.mol
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Donepezil Property

Melting point:
207°C
Boiling point:
527.9±50.0 °C(Predicted)
Density 
1.141±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Acetone (Slightly), Chloroform (Slightly)
form 
Solid
pka
8.84±0.10(Predicted)
color 
White to Off-White
Water Solubility 
2.931 mg/L
CAS DataBase Reference
120014-06-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-36/37/39
RIDADR 
UN 2811
HS Code 
29333990
Hazardous Substances Data
120014-06-4(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13245
Product name
Donepezil
Purity
≥95%
Packaging
10mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
13245
Product name
Donepezil
Purity
≥95%
Packaging
25mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
13245
Product name
Donepezil
Purity
≥95%
Packaging
50mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
13245
Product name
Donepezil
Purity
≥95%
Packaging
100mg
Price
$230
Updated
2024/03/01
TRC
Product number
D525745
Product name
Donepezil
Packaging
500mg
Price
$210
Updated
2021/12/16
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Donepezil Chemical Properties,Usage,Production

Description

Donepezil is another “nonclassic,” centrally acting, reversible, noncompetitive AChEI that was approved in 1997 for treatment of mild-to-moderate AD and dementia. Its selectivity for AChE is 570- to 1,250-fold that for butyrylcholinesterase, and it also exhibits greater affinity for brain AChE than for AChE in the periphery.

Uses

Donepezil is a cholinesterase inhibitors.

Uses

Acetylcholine is a neurotransmitter involved in neural signaling throughout the body. Donepezil is a reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine. It has a half-life in circulation of about 70 hours. As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil is commonly used in the treatment of Alzheimer’s disease to improve cognition, memory, and behavior. In this way, it is intended to prevent or reverse dementia. Studies on these effects have been equivocal, indicating that more research into the therapeutic potential of donepezil is warranted.[Cayman Chemical]

Definition

ChEBI: Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.

brand name

Aricept (Eisai Medical Research).

General Description

Donepezil, (±)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one (Aricept), commonly referred to in the literature asE2020, is a reversible inhibitor of AChE. It is indicated forthe treatment of symptoms of mild-to-moderate Alzheimerdisease. Donepezil is approximately 96% bound to plasmaproteins, with an elimination half-life of 70 hours. It is metabolizedprincipally by the 2D6 and 3A4 isozymes of theP450 system.

Metabolism

When compared to tacrine, donepezil exhibits greater CNS AChE selectivity, longer elimination half-life (70–104 hours in subjects older than 55 years) and little or no potential for hepatotoxicity. Donepezil is metabolized by CYP2D6 and CYP3A4 via demethylation, debenzylation, hydroxylation, oxidation to the cis-N-oxide, and glucuronidation. The 6-O-desmethyl metabolite accounts for 11% of a dose, and it exhibits AChE inhibitory activity comparable to that of the parent compound.

Donepezil Preparation Products And Raw materials

Raw materials

Preparation Products

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Donepezil Suppliers

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View Lastest Price from Donepezil manufacturers

Sinoway Industrial co., ltd.
Product
Donepezil 120014-06-4
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
99% up, High Density
Supply Ability
20 tons
Release date
2022-10-18
Anhui Dexinjia Biopharm Co., Ltd
Product
Donepezil 120014-06-4
Price
US $200.00-150.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20tons
Release date
2024-05-20
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Donepezil 120014-06-4
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
99%min
Supply Ability
1200kg/month
Release date
2021-06-07

120014-06-4, DonepezilRelated Search:

RAC (CIS/TRANS) DONEPEZIL N-OXIDE Scopolamine 5-(1-Hydroxy-2-tert-butylamino-ethyl)benzene-1,3-diol (S)-(+)-Benzyl glycidyl ether XWAIAVWHZJNZQQ-RPXFAUAJSA-N Nimodipine Aniracetam Metformin Paroxetine Piracetam Oxiracetam Donepezil Hydrochloride Memantine Rivastigmine 5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one 5-O-Desmethyl Donepezil 2-[(E)-(1-BENZYL-4-PIPERIDINYL)METHYLIDENE]-5,6-DIMETHOXY-1-INDANONE Dihydro Donepezil (Mixture of Diastereomers)

  • DONEPEZIL
  • AKOS 226-23
  • 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-1h-inde
  • n-1-one
  • N-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl] piperidine
  • 2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
  • 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL) METHYL] PIPERIDINE
  • 5,6-Dimethoxy-2,3-dihydro-1H-inden-1-one
  • Donezepil
  • 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride, hydrate(1:1:1)
  • Donepezil hydrochloride monohydrate
  • 2-[(1-Benzyl-4-piper
  • 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine
  • 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one
  • (2S)-2-[(1-benzylpiperidin-4-yl)Methyl]-5,6-diMethoxy-2,3-dihydro-1H-inden-1-one
  • 2-((1-Benzylpiperidin-4-yl)Methyl)-5,6-diMethoxy-2,3-dihydro-1H-inden-1-one
  • Donepezil hydrochloride Monohydra
  • Donepezil HCl (Base)
  • Donepezil InterMediate
  • Donepezil, >=99%
  • Donepezil(2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one)
  • Donepezil (as hydrochloride)
  • Aricept(Donepezil)
  • DONEPEZIL(E 2020)
  • (2R)-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-2,3-dihydroinden-1-one
  • Donepenil
  • 2-[(1-Benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
  • Donepezilo
  • 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-
  • 2-[((1-benzyl-4-piperidyl) methyl] -5, 6-dimethoxy-2, 3-dihydroindene - 1-one
  • Donepezil USP/EP/BP
  • Donepezine
  • DonepezilQ: What is Donepezil Q: What is the CAS Number of Donepezil Q: What is the storage condition of Donepezil Q: What are the applications of Donepezil
  • 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindanon-2-yl)methyl]piperidine
  • onepezil
  • HSDB 7743
  • HSDB7743
  • HSDB-7743
  • 2-(1-Benzyl-piperidin-4-ylmethyl)-5,6-dimethoxy-indan-1-one
  • Asciminib Impurity 15
  • 120014-06-4
  • C24H28NO3
  • C23H38InNO2
  • Isotope
  • Other APIs
  • 120014-06-4