ChemicalBook > CAS DataBase List > QUIN 2-AM

QUIN 2-AM

Product Name: QUIN 2-AM
CAS No.: 83104-85-2
Chemical Name: QUIN 2-AM
Synonyms: QUIN 2-AM;Quin 2 Am Ester;Acetoxymethyl ester;quin2-acetoxymethylester;Quin-2, AM *CAS 83104-85-2*;QUIN-2 TETRAACETOXYMETHYL ESTER;8-Amino-2-[(2-amino-5-methylphenoxy)-methyl]-6-methoxyquinoline-N,N,N',N'-tetraacetic acid;Tetrakis(acetoxymethyl) 8-amino-2-[(2-amino-5-methylphenoxy)methyl]-6-methoxyquinoline-N,N,N′,N′-tetraacetate;2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrakis(acetoxymethyl ester);2-[(2-AMINO-5-METHYLPHENOXY)METHYL]-6-METHOXY-8-AMINO-QUINOLINE-N,N,N',N'-TETRAACETIC ACID TETRAKIS(ACETOXYMETHYL-ESTER)
CBNumber: CB0158606
Molecular Formula: C38H43N3O18
Formula Weight: 829.76
MOL File: 83104-85-2.mol

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QUIN 2-AM Property

Density: 1.360
Flash point:: 113 °C
storage temp.: −20°C
solubility: DMSO: soluble
form: A solid
Appearance: Solid Powder
λmax: 348 nm
Biological Applications: Calcium indicator

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 1-8-10

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20422
Product name: Quin-2 AM
Purity: ≥90%
Packaging: 500μg
Price: $110
Updated: 2024/03/01

Cayman Chemical

Product number: 20422
Product name: Quin-2 AM
Purity: ≥90%
Packaging: 1mg
Price: $165
Updated: 2024/03/01

TRC

Product number: Q796703
Product name: Quin2-AM
Packaging: 1mg
Price: $120
Updated: 2021/12/16

TRC

Product number: Q796703
Product name: Quin2-AM
Packaging: 2.5mg
Price: $240
Updated: 2021/12/16

AK Scientific

Product number: 3974BA
Product name: Quin2-acetoxymethylester
Packaging: 1mg
Price: $280
Updated: 2021/12/16

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QUIN 2-AM Chemical Properties,Usage,Production

Description

Quin-2 AM is a cell-permeant acetoxymethyl ester of the high affinity fluorescent calcium indicator quin-2 . As quin-2 AM enters cells, it is hydrolyzed by intracellular esterases to produce quin-2. Quin-2 binds calcium with a K_d value of 115 nM. It displays high selectivity for calcium, as it is not affected by sodium gradients, membrane potential, or intracellular pH. High affinity probes like quin-2 are ideal for monitoring low levels of calcium, as are found in resting cells. Loadings of up to 2 mM quin-2 are without serious toxic effects, so quin-2 may be used to buffer intracellular calcium transients. Excitation and emission maxima for quin-2 are 339 and 492 nm, respectively.

Uses

Fluorescent probe for measurement of calcium in biological systems and for selected divalent cations.

Uses

2-[(2-Amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester)

Uses

Quin 2-AM is a cell permeable fluorescent probe for Ca2+ that gives a large shift in the UV absorption spectrum and a 20-fold increase in fluorescence upon Ca2+ binding.

References

[1] R Y TSIEN T J R T Pozzan. Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.[J]. Journal of Cell Biology, 1982, 94 2: 325-334. DOI: 10.1083/jcb.94.2.325
[2] A. MINTA R T J Kao. Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores.[J]. The Journal of Biological Chemistry, 1989, 13 1: 8171-8178. DOI: 10.1016/s0021-9258(18)83165-9

Excitation / Emission Maximum

339 nm/492 nm

QUIN 2-AM Preparation Products And Raw materials

Raw materials

Preparation Products

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83104-85-2, QUIN 2-AMRelated Search:

N-[2-[(Acetyloxy)methoxy]-2-oxoethyl]-N-[2-[2-[5-[6-[(acetyloxy)methoxy]-3-oxo-3H-xanthen-9-yl]-2-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]phenoxy]ethoxy]phenyl]glycine (acetyloxy)methyl ester Fluo 3-AM 2-METHOXY-N-METHYANILINE 2-Anilinoethanol 3-Dimethylaminoanisole Diethanolamine N-(2-Hydroxyethyl)-N-methylaniline Anilinoacetic acid N-Methyliminodiacetic acid 3-ETHYLAMINOPHENOL 2-[(2-amino-5-methylph2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium saltenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n N,N-DIMETHYLGLYCINE METHYL ESTER Iminodiacetic acid N-Ethyl-N-hydroxyethylaniline 3-METHOXY-N-METHYLANILINE 2-METHYLAMINOPHENOL N,N-BIS(2-HYDROXYETHYL)-3-METHOXYANILINE 8-Aminoquinaldine

QUIN 2-AM

QUIN-2 TETRAACETOXYMETHYL ESTER

2-[(2-AMINO-5-METHYLPHENOXY)METHYL]-6-METHOXY-8-AMINO-QUINOLINE-N,N,N',N'-TETRAACETIC ACID TETRAKIS(ACETOXYMETHYL-ESTER)

2-[[2-BIS(CARBOXYMETHYL)AMINO-5-METHYLPHENOXY]-METHYL]-6-METHOXY-8-BIS(CARBOXYMETHYL)AMINOQUINOLINE TETRAKIS(ACETOXYMETHYL) ESTER

quin2-acetoxymethylester

2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrakis(acetoxymethyl ester)

2-[(2-Amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-N,N,Nμ,Nμ-tetraacetic acid tetrakis(acetoxymethyl ester), 2-{[2-Bis(carboxymethyl)amino-5-methylphenoxy]-methyl}-6-methoxy-8-bis(carboxymethyl)aminoquinoline tetrakis(acetoxymethyl) ester

8-Amino-2-[(2-amino-5-methylphenoxy)-methyl]-6-methoxyquinoline-N,N,N',N'-tetraacetic acid

N-[2-[[8-[Bis(carboxymethyl)amino]-6-methoxy-2-quinolinyl]methoxy]-4-methylphenyl]-N-(carboxymethyl)glycine tetra(acetoxymethyl ester)

N-[2-[[8-[Bis[[(acetoxymethoxy)carbonyl]methyl]amino]-6-methoxy-2-quinolinyl]methoxy]-4-methylphenyl]-N-[[(acetoxymethoxy)carbonyl]methyl]glycine acetoxymethyl ester

N-[2-[(Acetyloxy)methoxy]-2-oxoethyl]-N-[2-[[8-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-6-methoxy-2-quinolinyl]methoxy]-4-methylphenyl]glycine (acetyloxy)methyl ester

2-[(2-amino-5-methylphenoxy)methyl]- 6-methoxy-8-aminoquinoline-n,n,n0,n0-tetraacetic acid Tetrakis(acetoxymethyl Ester)

Quin 2 Am Ester

Acetoxymethyl ester

Quin-2, AM *CAS 83104-85-2*

Glycine, N-(2-((acetyloxy)methoxy)-2-oxoethyl)-N-(2-((8-(bis(2-((acetyloxy)methoxy)-2-oxoethyl)amino)-6-methoxy-2-quinolinyl)methoxy)-4-methylphenyl)-, (acetyloxy)methyl ester

2-{[2-Bis(carboxymethyl)amino-5-methylphenoxy]-methyl}-6-methoxy-8-bis(carboxymethyl)aminoquinoline tetrakis(acetoxymethyl) ester

Tetrakis(acetoxymethyl) 8-amino-2-[(2-amino-5-methylphenoxy)methyl]-6-methoxyquinoline-N,N,N′,N′-tetraacetate

acetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[[8-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]-6-methoxyquinolin-2-yl]methoxy]-4-methylanilino]acetate

83104-85-2

C38H43N3O18

Quinoline