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N-Methyl-N-(trimethylsilyl)trifluoroacetamide

Product Name
N-Methyl-N-(trimethylsilyl)trifluoroacetamide
CAS No.
24589-78-4
Chemical Name
N-Methyl-N-(trimethylsilyl)trifluoroacetamide
Synonyms
MSTFA;DK232;MSTFA MSTFA;MSTFA Reagent;MSTFA ACTIVATED I;MSTFA+TMCS (99:1);MSTFA ACTIVATED II;MSTFA ACTIVATED III;MSTFA with 1 % TMCS;N-Methyl-N-(trimethy
CBNumber
CB0161574
Molecular Formula
C6H12F3NOSi
Formula Weight
199.25
MOL File
24589-78-4.mol
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N-Methyl-N-(trimethylsilyl)trifluoroacetamide Property

Melting point:
98-100°C
Boiling point:
130132°C
Density 
1.075 g/mL at 25 °C(lit.)
vapor density 
>1 (vs air)
vapor pressure 
8.8 mm Hg ( 27 °C)
refractive index 
n20/D 1.383
Flash point:
77 °F
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
pka
-1.34±0.70(Predicted)
form 
Liquid
color 
Clear colorless to light yellow
Specific Gravity
1.076
Water Solubility 
reacts
Sensitive 
Moisture Sensitive
Hydrolytic Sensitivity
7: reacts slowly with moisture/water
BRN 
1941550
InChIKey
MSPCIZMDDUQPGJ-UHFFFAOYSA-N
CAS DataBase Reference
24589-78-4(CAS DataBase Reference)
EPA Substance Registry System
Acetamide, 2,2,2-trifluoro-N-methyl-N-(trimethylsilyl)- (24589-78-4)
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Safety

Hazard Codes 
Xi,F,T,N
Risk Statements 
10-36/37/38-61-50/53-51/53
Safety Statements 
26-36-37/39-16-45-53-61
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
RTECS 
AC9800000
F 
10-21
Hazard Note 
Flammable
TSCA 
T
HazardClass 
3
PackingGroup 
III
HS Code 
29319090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.41102
Product name
N-Methyl-N-trimethylsilyl-trifluoroacetamide
Purity
for synthesis
Packaging
2ml
Price
$74.4
Updated
2024/03/01
Sigma-Aldrich
Product number
8.41102
Product name
N-Methyl-N-trimethylsilyl-trifluoroacetamide
Purity
for synthesis
Packaging
5ml
Price
$99.8
Updated
2024/03/01
Sigma-Aldrich
Product number
M-132
Product name
MSTFA Reagent
Purity
ampule of 10 × 1.2?mL, analytical standard, Cerilliant?
Packaging
10x1.2mL
Price
$144
Updated
2024/03/01
Sigma-Aldrich
Product number
8.41102
Product name
N-Methyl-N-trimethylsilyl-trifluoroacetamide
Purity
for synthesis
Packaging
25mL
Price
$283
Updated
2024/03/01
Sigma-Aldrich
Product number
69478
Product name
N-Methyl-N-(trimethylsilyl)trifluoroacetamide with 1% trimethylchlorosilane
Purity
for GC derivatization, LiChropur?
Packaging
1mL
Price
$57.2
Updated
2024/03/01
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N-Methyl-N-(trimethylsilyl)trifluoroacetamide Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to light yellow liquid

Uses

A new metabolite of Famprofazone in humans.

Uses

N-Methyl-N-(trimethylsilyl)trifluoroacetamide is used as a silylating reagent that forms volatile derivatives for GC-MS analysis. It acts as a pharmaceutical intermediate and metabolite of Famprofazone in humans. It is also used in the detection of steroid hormones 17-alfa-ethynylestradiol and estrone.

Definition

ChEBI: An N-silyl compound that is N-methyltrifluoroacetamide in which the amide nitrogen is replaced by a trimethylsilyl group. N-methyl-N-(trimethylsilyl)trifluoroacetamide is a derivat sation agent used in gas chromatography/mass spectrometry applications.

General Description

N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a derivatizing reagent. It can be used as alternatives to diazomethane.

Purification Methods

Fractionate the amide through a 40mm Vigreux column (p 11). Usually it contains ca 1% of methyl trifluoroacetamide and 1% of other impurities which can be removed by gas chromatography or fractionating using a spinning band column. [Donike J Chromatogr 42 103 1969, Donike J Chromatogr 103 91 1975, Beilstein 4 IV 4011.]

N-Methyl-N-(trimethylsilyl)trifluoroacetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Methyl-N-(trimethylsilyl)trifluoroacetamide Suppliers

Americas 1 Belgium 2 Canada 2 China 172 Europe 1 France 2 Germany 9 India 17 Italy 1 Japan 5 Norway 1 Singapore 1 Slovakia 1 Switzerland 3 United Kingdom 11 United States 54 Global 283
Matrix Fine Chemicals GmbH
Tel
--
Fax
--
Email
nfo@matrix-fine-chemicals.com
Country
Switzerland
ProdList
6968
Advantage
58
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
DKSH Switzerland Ltd.
Tel
--
Fax
--
Country
Switzerland
ProdList
520
Advantage
77
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View Lastest Price from N-Methyl-N-(trimethylsilyl)trifluoroacetamide manufacturers

Shandong Deshang Chemical Co., Ltd.
Product
N-Methyl-N-(trimethylsilyl)trifluoroacetamide 24589-78-4
Price
US $5.90-3.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 tons
Release date
2024-06-25
Hebei Chuanghai Biotechnology Co,.LTD
Product
N-Methyl-N- (trimethylsilyl) Trifluoroacetamide 24589-78-4
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-13
Hebei Fengjia New Material Co., Ltd
Product
N-Methyl-N-(trimethylsilyl)trifluoroacetamide 24589-78-4
Price
US $6.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2024-08-16

24589-78-4, N-Methyl-N-(trimethylsilyl)trifluoroacetamideRelated Search:

Thiophanate-methyl Bensulfuron methyl N-Methylacetamide Trifluoroacetamide Trifluoroacetamidine TRIMETHYLSILANE Hexamethyldisilane Methyltriacetoxysilane Methyl acetate Methyl acrylate Methylparaben Iodotrimethylsilane Azidotrimethylsilane Dichlorodimethylsilane Kresoxim-methyl Methyltriethoxysilane Methyltris(methylethylketoxime)silane N-(Trimethylsilyl)acetamide Mstfa Reagent

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