4-CYANOTHIAZOLE
- Product Name
- 4-CYANOTHIAZOLE
- CAS No.
- 1452-15-9
- Chemical Name
- 4-CYANOTHIAZOLE
- Synonyms
- 4-CYANOTHIAZOLE;4-thiazolecarbonitrile;thiazole-4-carbonitrile;1,3-thiazole-4-carbonitrile
- CBNumber
- CB0164818
- Molecular Formula
- C4H2N2S
- Formula Weight
- 110.14
- MOL File
- 1452-15-9.mol
4-CYANOTHIAZOLE Property
- Melting point:
- 60-61℃
- Boiling point:
- 100-120℃ (20 Torr)
- Density
- 1.393 (estimate)
- refractive index
- 1.5500 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -1.45±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
- EPA Substance Registry System
- 4-Thiazolecarbonitrile (1452-15-9)
Safety
- Risk Statements
- 10-20/21/22-36
- Safety Statements
- 16-26-36
- RIDADR
- 3275
- HS Code
- 2934100090
- Hazardous Substances Data
- 1452-15-9(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C982308
- Product name
- 4-Cyanothiazole
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C982308
- Product name
- 4-Cyanothiazole
- Packaging
- 100mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- FC154283
- Product name
- 4-Cyanothiazole
- Packaging
- 500mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- P000176588
- Product name
- 4-Cyanothiazole
- Purity
- 97%
- Packaging
- 100mg
- Price
- $39
- Updated
- 2021/12/16
- Product number
- P000176588
- Product name
- 4-Cyanothiazole
- Purity
- 97%
- Packaging
- 1g
- Price
- $131
- Updated
- 2021/12/16
4-CYANOTHIAZOLE Chemical Properties,Usage,Production
Uses
4-Cyanothiazole is a useful pharamaceutical intermediate.
Synthesis
3575-09-5
1452-15-9
General procedure for the synthesis of 4-cyanothiazole from thiazole-4-carboxamide: 500 g of thiazole-4-carboxamide (chemically pure) was added to a 1 L open reactor and the stirrer was started (600 r/min). Ammonia (chemically pure, 5.1 wt% water) was continuously vented from the bottom of the reactor at a controlled flow rate of 100 g/min. after TC hours of reaction at reaction temperature TA, the vented ammonia was stopped. Samples of the reaction mixture were taken for NMR hydrogen spectroscopy and elemental analysis to characterize the amide intermediates generated. The specific reaction conditions and characterization results are shown in Tables A-1 to A-6. The characterization results showed that the purity of the resulting amide intermediate was higher than 99%. In this embodiment, ammonia can be replaced by waste ammonia (source: Yangzi Petrochemical Plant, containing about 50 wt% ammonia, with toluene, oxygen, nitrogen, steam, carbon monoxide and carbon dioxide as the remaining components), at which time the flow rate of the waste ammonia should be adjusted to 130 g/min.
References
[1] Patent: CN104557357, 2018, B. Location in patent: Paragraph 0150; 0151; 0152; 0162
[2] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 6, p. 628 - 633
[3] Helvetica Chimica Acta, 1957, vol. 40, p. 554,558
[4] Bulletin de la Societe Chimique de France, 1969, p. 4026 - 4031
[5] Journal of the Chemical Society, 1960, p. 916 - 925
4-CYANOTHIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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