Methylglyoxal 1,1-dimethyl acetal
- Product Name
- Methylglyoxal 1,1-dimethyl acetal
- CAS No.
- 6342-56-9
- Chemical Name
- Methylglyoxal 1,1-dimethyl acetal
- Synonyms
- 1,1-Dimethoxypropan-2-one;1,1-DIMETHOXYACETONE;PYRUVIC ALDEHYDE DIMETHYL ACETAL;2,2-DiMethoxypropanal;2-Propanone, 1,1-dimethoxy-;Pyruvic aL;Pyruvaldehyde 1;1,1-Dimethoxyaceton;Methylglyoxal 1,1-di;1,1-Dimethoxypropanone
- CBNumber
- CB0166610
- Molecular Formula
- C5H10O3
- Formula Weight
- 118.13
- MOL File
- 6342-56-9.mol
Methylglyoxal 1,1-dimethyl acetal Property
- Melting point:
- -57 °C
- Boiling point:
- 143-147 °C(lit.)
- Density
- 0.976 g/mL at 25 °C(lit.)
- vapor pressure
- 11hPa at 20℃
- refractive index
- n20/D 1.398(lit.)
- Flash point:
- 100 °F
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- Liquid
- color
- Clear colorless to yellow
- Water Solubility
- MISCIBLE
- BRN
- 1560557
- InChI
- 1S/C5H10O3/c1-4(6)5(7-2)8-3/h5H,1-3H3
- InChIKey
- ULVSHNOGEVXRDR-UHFFFAOYSA-N
- SMILES
- COC(OC)C(C)=O
- LogP
- -0.199 (est)
- CAS DataBase Reference
- 6342-56-9
- NIST Chemistry Reference
- 2-Propanone, 1,1-dimethoxy-(6342-56-9)
- EPA Substance Registry System
- 2-Propanone, 1,1-dimethoxy- (6342-56-9)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 170216
- Product name
- Methylglyoxal 1,1-dimethyl acetal
- Purity
- ≥97%
- Packaging
- 100ml
- Price
- $94.4
- Updated
- 2025/07/31
- Product number
- 170216
- Product name
- Methylglyoxal 1,1-dimethyl acetal
- Purity
- ≥97%
- Packaging
- 500ml
- Price
- $179
- Updated
- 2025/07/31
- Product number
- P1264
- Product name
- Pyruvic Aldehyde Dimethyl Acetal
- Purity
- >97.0%(GC)
- Packaging
- 25mL
- Price
- $75
- Updated
- 2025/07/31
- Product number
- P1264
- Product name
- Pyruvic Aldehyde Dimethyl Acetal
- Purity
- >97.0%(GC)
- Packaging
- 100mL
- Price
- $154
- Updated
- 2025/07/31
- Product number
- P1264
- Product name
- Pyruvic Aldehyde Dimethyl Acetal
- Purity
- >97.0%(GC)
- Packaging
- 500mL
- Price
- $371
- Updated
- 2025/07/31
Methylglyoxal 1,1-dimethyl acetal Chemical Properties,Usage,Production
Chemical Properties
clear colorless to yellow liquid
Uses
Pyruvic Aldehyde Dimethyl Acetal is used in the preparation of MCL1 inhibitors S63845 which is tolerable and effective in diverse cancer models. Also, acts as a synthetic reagent for the preparation of 8novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase. Selective inhibition of neuronal nitric oxide synthase is an important therapeutic approach to target neurodegenerative disorders.
Uses
Methylglyoxal 1,1-dimethyl acetal was used in the synthesis of methylglyoxal via hydrolysis in the presence of H2SO4. It was used to investigate the effects of methylglyoxal-mediated glycation on the structure, thermal stability and enzyme activity of yeast enolase in vivo.
Synthesis Reference(s)
The Journal of Organic Chemistry, 41, p. 2642, 1976 DOI: 10.1021/jo00877a030
Synthesis
It is produced in two main stages. Stage 1: Preparation of acetone aldehyde monohydrate. 1,2-Propanediol undergoes gas-phase oxidation over a modified electrolytic silver catalyst. Optimal conditions: temperature 350-650??C, oxygen/alcohol ratio 1.1-1.2, space velocity 18,000-20,000 h?1. Conversion is 100%, methylglyoxal selectivity is 76%. Stage 2: Preparation of Methylglyoxal 1,1-dimethyl acetal. acetone aldehyde monohydrate reacts with methanol under reflux catalyzed by a modified resin. Distillation removes low-boilers and methanol. Steam distillation gives a crude solution. Dichloromethane extraction and rectification yield the pure product.
Methylglyoxal 1,1-dimethyl acetal Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methylglyoxal 1,1-dimethyl acetal manufacturers
- Product
- Methylglyoxal 1,1-dimethyl acetal 6342-56-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-02
- Product
- 1,1-Dimethoxyacetone 6342-56-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-24
- Product
- 1,1-Dimethoxyacetone 6342-56-9
- Price
- US $100.00-10.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20000kg per day
- Release date
- 2023-09-05