D-Homoserine
- Product Name
- D-Homoserine
- CAS No.
- 6027-21-0
- Chemical Name
- D-Homoserine
- Synonyms
- H-D-HSE-OH;D-Homoserin;D-HOMOSERINE;H-D-HOSER-OH;(R) HOMOSERINE;H-D-Homoser-OH;D-Beta-Homo-Ser;D-Homoserine>D-Homoserine,97%;dextro-homoserine
- CBNumber
- CB0168533
- Molecular Formula
- C4H9NO3
- Formula Weight
- 119.12
- MOL File
- 6027-21-0.mol
D-Homoserine Property
- Melting point:
- 205 °C (dec.) (lit.)
- alpha
- 9 º ((c=5, H2O))
- Boiling point:
- 368.7±32.0 °C(Predicted)
- Density
- 1.312±0.06 g/cm3(Predicted)
- refractive index
- 8.0 ° (C=2, H2O)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- pka
- 2.21±0.10(Predicted)
- form
- powder to crystal
- color
- White to Orange to Green
- Water Solubility
- Soluble
- BRN
- 1721680
- InChI
- InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m1/s1
- InChIKey
- UKAUYVFTDYCKQA-GSVOUGTGSA-N
- SMILES
- C(O)(=O)[C@@H](CCO)N
- LogP
- -1.289 (est)
- CAS DataBase Reference
- 6027-21-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- H4021
- Product name
- D-Homoserine
- Packaging
- 250mg
- Price
- $96
- Updated
- 2025/07/31
- Product number
- H4021
- Product name
- D-Homoserine
- Packaging
- 1g
- Price
- $667
- Updated
- 2025/07/31
- Product number
- H1224
- Product name
- D-Homoserine
- Purity
- >96.0%(T)
- Packaging
- 1g
- Price
- $86
- Updated
- 2025/07/31
- Product number
- H1224
- Product name
- D-Homoserine
- Purity
- >96.0%(T)
- Packaging
- 5g
- Price
- $254
- Updated
- 2025/07/31
- Product number
- H615123
- Product name
- D-Homoserine
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
D-Homoserine Chemical Properties,Usage,Production
Chemical Properties
White to lightbyellow crystalline powder
Uses
peptide synthesis
Definition
ChEBI: The D-enantiomer of homoserine.
Biochem/physiol Actions
D-Homoserine is used for the synthesis of bacterial polysaccharids such as the O-antigen of Acinetobacter lwoffii EK30A. D-Homoserine is used to produce atypical serine protease(s) for mechanism studies.
Synthesis
348-67-4
6027-21-0
The general procedure for the synthesis of D-homoserine from D-methionine was as follows: D-methionine (1) (25.0 g, 167.5 mmol, 1 eq.) was suspended in a mixed H2O/MeOH solvent (466 mL/66 mL) according to the literature method, followed by the addition of methyl iodide (25.2 mL, 405.4 mmol, 2.4 eq.). The resulting suspension was stirred vigorously at room temperature for 48 hours. Upon completion of the reaction, the volume of the reaction mixture was concentrated to one-third of the original volume by vacuum evaporation, while the excess methyl iodide was removed. To the remaining reaction mixture was added water (155 mL) followed by NaHCO3 (14.07 g, 167.5 mmol, 1 equiv). The resulting solution was refluxed for 15 hours and then cooled to room temperature. The solvent was removed under vacuum to give a thick syrupy substance. The syrupy substance was dissolved in water (45 mL) under heating, followed by sequential addition of acetone (90 mL) and ethanol (1000 mL), and a white solid precipitate was observed. The precipitate was filtered and dried under vacuum to give a white solid of the target product D-homoserine (2). Yield: 9.9 g (83 mmol, 50% yield). Melting point: 202°C. 1H NMR (300 MHz, D2O): δ = 1.92-1.78 (m, 1H, 3-CH), 2.09-2.92 (m, 1H, 3-CH), 3.65-3.58 (m, 2H, 4-CH2), 3.68 (dd, 3JH,H = 4.8, 3JH,H = 7.5 Hz, 1H, 2-CH ).13C NMR (75 MHz, D2O): δ = 32.1 (s, 3-C), 53.3 (s, 2-C), 58.5 (s, 4-C), 174.5 (s, 1-C).HRMS (ESI+, MeOH): m/z = 142.0468 [M + Na]+ with a calculated value of 142.0475 for C4H9NO3Na.
References
[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 19, p. 5168 - 5181
[2] Tetrahedron, 1988, vol. 44, # 2, p. 637 - 642
D-Homoserine Preparation Products And Raw materials
Raw materials
Preparation Products
D-Homoserine Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
- Tel
- --
- Fax
- --
- Sales@kemikalieimport.dk
- Country
- Europe
- ProdList
- 6685
- Advantage
- 47
View Lastest Price from D-Homoserine manufacturers
- Product
- D-Homoserine 6027-21-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 5000kg/month
- Release date
- 2021-10-13
- Product
- D-Homoserine 6027-21-0
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2024-08-16
- Product
- D-Homoserine 6027-21-0
- Price
- US $9.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2024-12-05