N-BUTYLIDENEPHTHALIDE
Description Reference- Product Name
- N-BUTYLIDENEPHTHALIDE
- CAS No.
- 551-08-6
- Chemical Name
- N-BUTYLIDENEPHTHALIDE
- Synonyms
- 3-BUTYLIDENEPHTHALIDE;Bdph;BUTYLIDENE PHTHALIDE;3-butylidene-phthalid;3-Butylideneisobenzofuran-1(3H)-one;FEMA 3333;Ai3-37306;NSC 325307;Einecs 208-991-3;Butenylphthalide
- CBNumber
- CB0173298
- Molecular Formula
- C12H12O2
- Formula Weight
- 188.22
- MOL File
- 551-08-6.mol
N-BUTYLIDENEPHTHALIDE Property
- Melting point:
- 82.5°C
- Boiling point:
- 139-142 °C/5 mmHg (lit.)
- Density
- 1.103 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.577(lit.)
- FEMA
- 3333 | 3-BUTYLIDENEPHTHALIDE
- Flash point:
- >230 °F
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Oil
- color
- Colourless to Yellow
- Odor
- at 10.00 % in dipropylene glycol. herbal lovage celery
- Odor Type
- herbal
- JECFA Number
- 1170
- BRN
- 5145
- InChIKey
- WMBOCUXXNSOQHM-FLIBITNWSA-N
- LogP
- 3.72
- CAS DataBase Reference
- 551-08-6(CAS DataBase Reference)
- EPA Substance Registry System
- 1(3H)-Isobenzofuranone, 3-butylidene- (551-08-6)
N-Bromosuccinimide Price
- Product number
- A10353
- Product name
- n-Butylidenephthalide, (E)+(Z), 95%
- Packaging
- 10g
- Price
- $31.65
- Updated
- 2024/03/01
- Product number
- A10353
- Product name
- n-Butylidenephthalide, (E)+(Z), 95%
- Packaging
- 50g
- Price
- $90.65
- Updated
- 2024/03/01
- Product number
- A10353
- Product name
- n-Butylidenephthalide, (E)+(Z), 95%
- Packaging
- 250g
- Price
- $342
- Updated
- 2023/06/20
- Product number
- 299818
- Product name
- 3-Butylidenephthalide
- Packaging
- 20mg
- Price
- $297
- Updated
- 2021/12/16
- Product number
- B692250
- Product name
- 3-ButylidenePhthalide(CisTransmixture)
- Packaging
- 25g
- Price
- $425
- Updated
- 2021/12/16
N-BUTYLIDENEPHTHALIDE Chemical Properties,Usage,Production
Description
N-Butylidenephthalide is a phthalide derivative useful for control of sensation disorder and olfaction disorder. It is a bioactive phthalide compound of Chuanxiong rhizoma, a Chinese herbal medicine used for treating headache obtained from the root of Ligusticum chuanxiong Hort. It has found that it can regulate tumor stem cell genes EZH2/AXL and reduced its migration and invasion in glioblastoma. Moreover, it can induce apoptosis in the A549 human lung adenocarcinoma cell line by coupled down-regulation of AP-2a and telomerase activity. Therefore, it is a potential cancer chemotherapy drug. Moreover, It can also exhibit protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3. Finally, it has certain antiplatelet effect.
Reference
- Lin, Po Cheng, et al. "Orphan nuclear receptor, Nurr‐77 was a possible target gene of butylidenephthalide chemotherapy on glioblastoma multiform brain tumor." Journal of Neurochemistry 106.3(2010):1017-1026.
- Rajamani, K, et al. "n-Butylidenephthalide exhibits protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3." Neuropharmacology 117(2017):434-446.
- Teng, C. M., et al. "Antiplatelet effect of butylidenephthalide." BBA General Subjects 924.3(1987):375-382.
Chemical Properties
3-Butylidenephthalide has a pervasive warm spicy aroma.
Occurrence
Reported as occurring naturally in the fruits and roots of Ligusticum acutilobum and lovage (Levisticum officinale) seeds, roots and leaves.
Uses
3-Butylidenephthalide is a phthalide derivative useful for control of sensation disorder and olfaction disorder.
Definition
ChEBI: A gamma-lactone that is phthalide substituted by a butylidene group at position 3. Isolated from Ligusticum porteri, it exhibits hypoglycemic activity.
Taste threshold values
Taste characteristics at 15 ppm: celery, green, vegetable-like with a herbal nuance.
General Description
3-Butylidenephthalide is a bioactive phthalide compound of Chuanxiong rhizoma, a Chinese herbal medicine used for treating headache obtained from the root of Ligusticum chuanxiong Hort.
Safety Profile
Moderately toxic by ingestion. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
target
Nrf2 | TNF-α | NO | IL Receptor
N-BUTYLIDENEPHTHALIDE Preparation Products And Raw materials
Raw materials
Preparation Products
N-BUTYLIDENEPHTHALIDE Suppliers
- Tel
- --
- Fax
- --
- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71
- Tel
- --
- Fax
- --
- info@abcr.de
- Country
- Germany
- ProdList
- 6831
- Advantage
- 75
View Lastest Price from N-BUTYLIDENEPHTHALIDE manufacturers
- Product
- Butyphthalide impurity 20 551-08-6
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 5g
- Release date
- 2024-05-22
- Product
- N-BUTYLIDENEPHTHALIDE 551-08-6
- Price
- US $5.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 100000
- Release date
- 2024-08-16
- Product
- N-BUTYLIDENEPHTHALIDE 551-08-6
- Price
- US $1.00/PCS
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2021-06-23