Phthalide

Product Name: Phthalide
CAS No.: 87-41-2
Chemical Name: Phthalide
Synonyms: Isobenzofuran-1(3H)-one;1(3H)-ISOBENZOFURANONE;ISOBENZOFURANONE;2-Benzofuran-1(3H)-one;PHTHALIDE;Phthalanone;AKOS 243-03;OXOPHTHALANE;Phthalide99%;Phthalide>
CBNumber: CB3245950
Molecular Formula: C8H6O2
Formula Weight: 134.13
MOL File: 87-41-2.mol

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Phthalide Property

Melting point:: 71-74 °C (lit.)
Boiling point:: 290 °C (lit.)
Density: 1.1
refractive index: 1.5360 (estimate)
FEMA: 4195 | PHTHALIDE
Flash point:: 152 °C
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Crystalline Powder
color: White to light beige
Odor: at 100.00 %. sweet tonka coumarin powdery coconut phenolic lactonic
Odor Type: coumarinic
Water Solubility: sparingly soluble
BRN: 114632
Dielectric constant: 36.0
Dielectric constant: 36.0（23℃）
InChIKey: WNZQDUSMALZDQF-UHFFFAOYSA-N
LogP: 0.99
CAS DataBase Reference: 87-41-2(CAS DataBase Reference)
NIST Chemistry Reference: 1(3H)-Isobenzofuranone(87-41-2)
EPA Substance Registry System: Phthalide (87-41-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36-36/37/38
Safety Statements: 26-36-24/25-37/39
WGK Germany: 3
RTECS: TI3520000
TSCA: Yes
HS Code: 29322980

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P39605
Product name: Phthalide
Purity: 98%
Packaging: 100g
Price: $48
Updated: 2024/03/01

Sigma-Aldrich

Product number: 55906
Product name: Phthalide
Purity: analytical standard
Packaging: 100mg
Price: $67.8
Updated: 2022/05/15

TCI Chemical

Product number: P0401
Product name: Phthalide
Purity: >98.0%(GC)
Packaging: 25g
Price: $16
Updated: 2024/03/01

TCI Chemical

Product number: P0401
Product name: Phthalide
Purity: >98.0%(GC)
Packaging: 500g
Price: $90
Updated: 2024/03/01

Alfa Aesar

Product number: A15516
Product name: Phthalide, 98+%
Packaging: 100g
Price: $29.65
Updated: 2024/03/01

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Phthalide Chemical Properties,Usage,Production

Description

White powder; sweet tonka, coumarin, powdery, coconut, phenolic, lactonic aroma.

Uses

Phthalide may be used in scaffolds for the design of high potency monoamine oxidase (MAO) inhibitors.

Definition

ChEBI: A gamma-lactone that is 1,3-dihydro-2-benzofuran in which the hydrogens at position 1 are replaced by an oxo group.

Aroma threshold values

Low strength odor, Tonka type.

Taste threshold values

Sweet coumarin, coconut, creamy, anisic, green vegetable, floral taste at 100 ppm in water.

Synthesis Reference(s)

Chemistry Letters, 23, p. 1149, 1994
The Journal of Organic Chemistry, 68, p. 9423, 2003 DOI: 10.1021/jo0350763
Tetrahedron Letters, 7, p. 6097, 1966

Flammability and Explosibility

Not classified

Pharmacology

Systemic fungicide giving effective preventive control of the rice blast fungus in rice as foliar spray.

Purification Methods

Crystallise phthalide from water (75mL/g) and dry it in air on filter paper. [Beilstein 17/10 V 7.]

Toxicity evaluation

Mammalian toxicology. Oral: Acute oral LD₅₀ for rats and mice >10000 mg/kg. Skin and eye: Acute percutaneous LD₅₀ for rats and mice >10000 mg/kg. Not a shaved skin irritant, eye irritant (rabbits). Inhalation LC50 (4 h) for rats >4.1 mg/L air. NOEL: (2 yr) for rats 2000, mice 100 mg/kg diet.

Phthalide Preparation Products And Raw materials

Raw materials

ZINC Phthalimide Copper(II) sulfate

Preparation Products

1,4-DICHLOROANTHRAQUINONE 2-(Bromomethyl)benzoic acid PYRIFTALID 2-Carboxybenzaldehyde 2-(Phenoxymethyl)benzoic acid

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Phthalide Suppliers

Americas 1 Belgium 1 Canada 4 China 375 Europe 5 France 2 Germany 10 India 49 Japan 6 Slovakia 1 South Korea 2 Switzerland 3 The Netherlands 1 Ukraine 1 United Kingdom 11 United States 45 USA 1 Global 518

Shanghai Harvest Chemical Industrial Co., Ltd.

Tel: 21-31038972 15721252604
Fax: +86-21-51385350
Email: ammyzuo@harvest-chem.com
Country: China
ProdList: 2540
Advantage: 64

Wuxi enqiao Pharmaceutical Technology Co., Ltd

Tel: 0510-83591909 18018392058
Fax: 0510-83591909
Email: info@enbridgepharm.com
Country: China
ProdList: 237
Advantage: 58

Hubei Zhonglong Kangsheng Fine Chemical Co., Ltd.

Tel: 15926260361
Fax: QQ:1930063008
Email: 1930063008@qq.com
Country: China
ProdList: 2160
Advantage: 58

Jinan Jinchi Pharmaceutical Technology Co., LTD

Tel: 15168890063 18888326116
Email: 76337143@qq.com
Country: China
ProdList: 55
Advantage: 58

Weifang Runzhong Fine Chemical Co., LTD

Tel: 18653686003
Email: sq@runzhongchem.com
Country: China
ProdList: 71
Advantage: 58

Xi'an Beckman Chemical Technology Co., Ltd.

Tel: 029-81136681 15309292692
Email: fangxianwen@xa-bkm.com
Country: China
ProdList: 30
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

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View Lastest Price from Phthalide manufacturers

Hubei Lidu New Material Technology Co., Ltd

Product: PHTHALIDE 87-41-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2024-10-30

Jinan Finer Chemical Co., Ltd

Product: Phthalide 87-41-2
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%
Supply Ability: 100mt
Release date: 2019-10-17

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Phthalide 87-41-2
Price: US $65.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-05-27

87-41-2, PhthalideRelated Search:

3-(Trifluoromethyl)benzoic acid p-Toluic acid Methyl 4-methylbenzoate Methyl 4-(bromomethyl)benzoate m-Toluic acid o-Toluic acid ISOCHROMAN-4-ONE IsochroMan-4-ol 3,4-DIHYDRO-1H-ISOCHROMEN-3-OL 1H-2-Benzopyran-6-ol, 3,4-dihydro- (9CI) (+)-Bicuculline Pyromellitic Dianhydride ERYTHROSIN B 5(6)-Aminofluorescein Fluorescein diacetate 6-Aminofluorescein Fluorescein isothiocyanate Anthranilic acid

3H-2-Benzofuran-1-one

1,3-Dihydroisobenzofuran-1-one

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O-Hydroxymethylbenzoic Acid Lactone (Phthalanone)

SPECS AE-641/30105043

PHTHALIDE

OXOPHTHALANE

O-HYDROXYMETHYLBENZOIC ACID LACTONE

Chlortalidone Impurity 7

Butylphthalide Impurity 4

Phthalide 1(3H)-Isobenzofuranone

Chlortalidone Impurity 17

1,3-Dihydrobenzo[C]furan-2-one

2-Benzofuran-1(3H)-one

2-Hydroxymethylbenzoic acid, gamma-lactone

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1-OXOPHTHALAN

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1,3-DIHYDROBENZO[C]FURAN-1-ONE

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α-Hydroxy-o-toluic acid lactone

AKOS 243-03

A-HYDROXY-O-TOLUIC ACID LACTONE

BENZO(C)FURAN-2-ONE

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LABOTEST-BB LT00068498

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Phthalide&gt

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1-Isobenzofuranone (Phthalide)

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Butylphthalide Impurity 4（Chlortalidone Impurity 7）

Isobenzofuranone in Acetonitrile

C14382000 Isobenzofuranone

87-41-2

C6H4COOCH2

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Carbonyl Compounds

Chemical Synthesis