Phthalide

ChemicalBook > CAS DataBase List > Phthalide

Product Name: Phthalide
CAS No.: 87-41-2
Chemical Name: Phthalide
Synonyms: Isobenzofuran-1(3H)-one;1(3H)-ISOBENZOFURANONE;ISOBENZOFURANONE;2-Benzofuran-1(3H)-one;PHTHALIDE;Phthalanone;AKOS 243-03;OXOPHTHALANE;Phthalide99%;Phthalide>
CBNumber: CB3245950
Molecular Formula: C8H6O2
Formula Weight: 134.13
MOL File: 87-41-2.mol

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Phthalide Property

Melting point:: 71-74 °C (lit.)
Boiling point:: 290 °C (lit.)
Density: 1.1
refractive index: 1.5360 (estimate)
FEMA: 4195 | PHTHALIDE
Flash point:: 152 °C
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Crystalline Powder
color: White to light beige
Odor: at 100.00 %. sweet tonka coumarin powdery coconut phenolic lactonic
Odor Type: coumarinic
Water Solubility: sparingly soluble
BRN: 114632
Dielectric constant: 36.0
Dielectric constant: 36.0（23℃）
InChIKey: WNZQDUSMALZDQF-UHFFFAOYSA-N
LogP: 0.99
CAS DataBase Reference: 87-41-2(CAS DataBase Reference)
NIST Chemistry Reference: 1(3H)-Isobenzofuranone(87-41-2)
EPA Substance Registry System: Phthalide (87-41-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36-36/37/38
Safety Statements: 26-36-24/25-37/39
WGK Germany: 3
RTECS: TI3520000
TSCA: Yes
HS Code: 29322980

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P39605
Product name: Phthalide
Purity: 98%
Packaging: 100g
Price: $48
Updated: 2024/03/01

Sigma-Aldrich

Product number: 55906
Product name: Phthalide
Purity: analytical standard
Packaging: 100mg
Price: $67.8
Updated: 2022/05/15

TCI Chemical

Product number: P0401
Product name: Phthalide
Purity: >98.0%(GC)
Packaging: 25g
Price: $16
Updated: 2024/03/01

TCI Chemical

Product number: P0401
Product name: Phthalide
Purity: >98.0%(GC)
Packaging: 500g
Price: $90
Updated: 2024/03/01

Alfa Aesar

Product number: A15516
Product name: Phthalide, 98+%
Packaging: 100g
Price: $29.65
Updated: 2024/03/01

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Phthalide Chemical Properties,Usage,Production

Description

White powder; sweet tonka, coumarin, powdery, coconut, phenolic, lactonic aroma.

Uses

Phthalide may be used in scaffolds for the design of high potency monoamine oxidase (MAO) inhibitors.

Definition

ChEBI: A gamma-lactone that is 1,3-dihydro-2-benzofuran in which the hydrogens at position 1 are replaced by an oxo group.

Aroma threshold values

Low strength odor, Tonka type.

Taste threshold values

Sweet coumarin, coconut, creamy, anisic, green vegetable, floral taste at 100 ppm in water.

Synthesis Reference(s)

Chemistry Letters, 23, p. 1149, 1994
The Journal of Organic Chemistry, 68, p. 9423, 2003 DOI: 10.1021/jo0350763
Tetrahedron Letters, 7, p. 6097, 1966

Flammability and Explosibility

Not classified

Pharmacology

Systemic fungicide giving effective preventive control of the rice blast fungus in rice as foliar spray.

Purification Methods

Crystallise phthalide from water (75mL/g) and dry it in air on filter paper. [Beilstein 17/10 V 7.]

Toxicity evaluation

Mammalian toxicology. Oral: Acute oral LD₅₀ for rats and mice >10000 mg/kg. Skin and eye: Acute percutaneous LD₅₀ for rats and mice >10000 mg/kg. Not a shaved skin irritant, eye irritant (rabbits). Inhalation LC50 (4 h) for rats >4.1 mg/L air. NOEL: (2 yr) for rats 2000, mice 100 mg/kg diet.

Phthalide Preparation Products And Raw materials

Raw materials

ZINC Phthalimide Copper(II) sulfate

Preparation Products

1,4-DICHLOROANTHRAQUINONE 2-(Bromomethyl)benzoic acid PYRIFTALID 2-Carboxybenzaldehyde 2-(Phenoxymethyl)benzoic acid

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View Lastest Price from Phthalide manufacturers

Hubei Lidu New Material Technology Co., Ltd

Product: PHTHALIDE 87-41-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2024-10-30

Jinan Finer Chemical Co., Ltd

Product: Phthalide 87-41-2
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%
Supply Ability: 100mt
Release date: 2019-10-17

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Phthalide 87-41-2
Price: US $65.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-05-27

87-41-2, PhthalideRelated Search:

3-(Trifluoromethyl)benzoic acid p-Toluic acid Methyl 4-methylbenzoate Methyl 4-(bromomethyl)benzoate m-Toluic acid o-Toluic acid ISOCHROMAN-4-ONE IsochroMan-4-ol 3,4-DIHYDRO-1H-ISOCHROMEN-3-OL 1H-2-Benzopyran-6-ol, 3,4-dihydro- (9CI) (+)-Bicuculline Pyromellitic Dianhydride ERYTHROSIN B 5(6)-Aminofluorescein Fluorescein diacetate 6-Aminofluorescein Fluorescein isothiocyanate Anthranilic acid

3H-2-Benzofuran-1-one

1,3-Dihydroisobenzofuran-1-one

Isobenzofuran-1(3H)-one

Phthalanone

Phthalide,1-Isobenzofuranone

Phthalide, 99% 5GR

PHTHALIDE FOR SYNTHESIS 100 G

PHTHALIDE FOR SYNTHESIS 250 G

Phthalide 98%

O-Hydroxymethylbenzoic Acid Lactone (Phthalanone)

SPECS AE-641/30105043

PHTHALIDE

OXOPHTHALANE

O-HYDROXYMETHYLBENZOIC ACID LACTONE

Chlortalidone Impurity 7

Butylphthalide Impurity 4

Phthalide 1(3H)-Isobenzofuranone

Chlortalidone Impurity 17

1,3-Dihydrobenzo[C]furan-2-one

2-Benzofuran-1(3H)-one

2-Hydroxymethylbenzoic acid, gamma-lactone

Phthalolactone

1-PHTHALANONE

1-OXOPHTHALAN

2-BENZOFURAN-(3H)-ONE

1-ISOBENZOFURANONE

1(3H)-ISOBENZOFURANONE

1,3-DIHYDROBENZO[C]FURAN-1-ONE

Phthalide99%

Phthalide, 96+%

Phthalide,98+%

α-Hydroxy-o-toluic acid lactone

AKOS 243-03

A-HYDROXY-O-TOLUIC ACID LACTONE

BENZO(C)FURAN-2-ONE

ISOBENZOFURANONE

LABOTEST-BB LT00068498

PHTHALIDE pure

2-Hydroxymethylbenzoic acid g-lactone

o-Hydruxymethy/benzoic acid lactone

Phthalide&gt

1-Isobenzofuranone (Phthalide)@100 μg/mL in Methanol

1-Isobenzofuranone (Phthalide)

Phthalide (6CI, 8CI)

Butylphthalide Impurity 4（Chlortalidone Impurity 7）

Isobenzofuranone in Acetonitrile

C14382000 Isobenzofuranone

87-41-2

C6H4COOCH2

Building Blocks

Benzofurans

Carbonyl Compounds

Organic Building Blocks

Lactones

Heterocyclic Building Blocks

Building Blocks

Carbonyl Compounds

Chemical Synthesis