ChemicalBook > CAS DataBase List > 3-CHLORO-2,5-DIMETHYLPYRAZINE

3-CHLORO-2,5-DIMETHYLPYRAZINE

Product Name
3-CHLORO-2,5-DIMETHYLPYRAZINE
CAS No.
95-89-6
Chemical Name
3-CHLORO-2,5-DIMETHYLPYRAZINE
Synonyms
3-CHLORO-2,5-DIMETHYLPIAZINE;2,5-Dimethyl-3-chloropyrazine;3-CHLORO-2,5-DIMETHYLPYRAZINE;Pyrazine, 3-chloro-2,5-dimethyl-;3-CHLORO-2,5-DIMETHYL-1,4-DIAZINE;3-Chloro-2,5-dimethylpyrazine,93%;3-Chloro-2,5-dimethylpyrazine >3-Chloro-2,5-diMethylpyrazine 98%;3-Chloro-2,5-diMethylpyrazine, 97+%;3-CHLORO-2,5-DIMETHYLPYRAZINE ISO 9001：2015 REACH
CBNumber
CB0176239
Molecular Formula
C6H7ClN2
Formula Weight
142.59
MOL File
95-89-6.mol
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3-CHLORO-2,5-DIMETHYLPYRAZINE Property

Boiling point:
66-69 °C/9 mmHg (lit.)
Density 
1.181 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.527(lit.)
Flash point:
182 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
clear liquid
pka
-0.11±0.10(Predicted)
color 
Colorless to Light orange to Yellow
InChIKey
NNBALVIZMGWZHS-UHFFFAOYSA-N
CAS DataBase Reference
95-89-6(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
WGK Germany 
3
RTECS 
UQ2462000
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C38400
Product name
3-Chloro-2,5-dimethylpyrazine
Purity
98%
Packaging
25g
Price
$74.6
Updated
2023/06/20
TCI Chemical
Product number
C2040
Product name
3-Chloro-2,5-dimethylpyrazine
Purity
>95.0%(GC)
Packaging
5g
Price
$104
Updated
2025/07/31
TRC
Product number
C365855
Product name
3-Chloro-2,5-dimethylpyrazine
Packaging
100g
Price
$525
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC42536
Product name
3-Chloro-2,5-dimethylpyrazine
Packaging
25g
Price
$300
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC42536
Product name
3-Chloro-2,5-dimethylpyrazine
Packaging
50g
Price
$500
Updated
2021/12/16
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3-CHLORO-2,5-DIMETHYLPYRAZINE Chemical Properties,Usage,Production

Chemical Properties

Brown liquid

Uses

3-Chloro-2,5-dimethylpyrazine participates in cross-coupling reactions involving chlroropyrazines with 1-substituted indoles. Occasionally this reaction is catalyzed by iron.

Synthesis

6890-37-5

95-89-6

General procedure for the synthesis of 3-chloro-2,5-dimethylpyrazine from 2,5-dimethylpyrazine 1-oxide: 2,5-dimethylpyrazine 1-oxide (7,15.0 g, 121 mmol) and phosphorous trichloride (POCl3, 55.1 g, 360 mmol) were mixed, and the mixture was stirred and heated for 30 min at 60 °C. (Note: Caution is required during handling, as there have been reports of explosions during mixing). Upon completion of the reaction, the mixture was cooled to room temperature and subsequently poured in batches into ice water. The pH was adjusted to alkaline with 20% aqueous sodium hydroxide (NaOH) and then extracted with ether (Et2O). The organic phase was washed sequentially with water and saturated saline, dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure. Distillation of the residue gave 12.2 g (71% yield) of 3-chloro-2,5-dimethylpyrazine as a light yellow oil with a boiling point of 98-100 °C/40 Torr. Its infrared spectrum (νmax, membrane method) showed characteristic absorption peaks: 3045 (w), 2999 (w), 2962 (w), 2925 (w), 1567 (w), 1519 ( w), 1454 (s), 1377 (m), 1329 (s), 1313 (s), 1248 (m), 1168 (m), 1088 (s), 968 (m), 456 (m) cm-1. NMR hydrogen spectrum (δH, CDCl3): 2.49 (3H, s), 2.59 (3H, s), 8.23 (1H, s); NMR carbon spectrum (δC, CDCl3): 21.2,22.3,142.1,148.3,150.1,151.7.

References

[1] European Journal of Organic Chemistry, 2010, # 14, p. 2687 - 2695
[2] Tetrahedron, 2017, vol. 73, # 32, p. 4766 - 4769
[3] Organic Letters, 2012, vol. 14, # 10, p. 2576 - 2578
[4] Journal of the American Chemical Society, 1951, vol. 73, p. 2949
[5] Journal of the Chemical Society, 1947, p. 1183

3-CHLORO-2,5-DIMETHYLPYRAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-CHLORO-2,5-DIMETHYLPYRAZINE Suppliers

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View Lastest Price from 3-CHLORO-2,5-DIMETHYLPYRAZINE manufacturers

Hebei Fengjia New Material Co., Ltd
Product
3-CHLORO-2,5-DIMETHYLPYRAZINE 95-89-6
Price
US $5.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2024-08-16
Hebei Chuanghai Biotechnology Co., Ltd
Product
3-CHLORO-2,5-DIMETHYLPYRAZINE 95-89-6
Price
US $9.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
5tons
Release date
2024-12-05
Honest Joy Holdings Limited
Product
3-Chloro-2,5-dimethylpyrazine 95-89-6
Price
US $0.00/KG
Min. Order
1KG
Purity
98.1%
Supply Ability
100 tons
Release date
2022-02-18

95-89-6, 3-CHLORO-2,5-DIMETHYLPYRAZINERelated Search:

LanthanuM(III) chloride hydrate 4-Amino-3-fluoropyridine 3-(4-BROMOBENZOYL)PROPIONIC ACID 2,4-Difluoronitrobenzene Propyleneglycol alginate 4-Bromo-3-fluoroanisole 2,5-Dimethyl pyrazine 3-CHLORO-2,5-DIMETHYLPYRAZINE 3-CHLORO-2,5-DIETHYL PYRAZINE 3-Chloro-5-methyl-pyrazine-2-carboxylic acid methyl ester 2,5-DICHLORO-3,6-DIMETHYLPYRAZINE 2-CHLORO-3,5,6-TRIPHENYLPYRAZINE 2,5-DICHLORO-3,6-DIPHENYL PYRAZINE METHYL 3-CHLORO-5-PHENYLPYRAZINE-2-CARBOXYLATE 2-CHLORO-5-HYDRAZINO-3,6-DIPHENYLPYRAZINE 3-CHLORO-2,6-DIMETHYLPYRAZINE 2,5-DICHLORO-3,6-DIETHYL-PYRAZINE 3-CHLORO-2,5-DIPHENYLPYRAZINE

  • Pyrazine, 3-chloro-2,5-dimethyl-
  • 3-CHLORO-2,5-DIMETHYL-1,4-DIAZINE
  • 3-CHLORO-2,5-DIMETHYLPIAZINE
  • 3-CHLORO-2,5-DIMETHYLPYRAZINE
  • 2,5-Dimethyl-3-chloropyrazine
  • 3-Chloro-2,5-diMethylpyrazine, 97+%
  • 3-Chloro-2,5-diMethylpyrazine 98%
  • 3-Chloro-2,5-dimethylpyrazine &gt
  • 3-CHLORO-2,5-DIMETHYLPYRAZINE ISO 9001：2015 REACH
  • 3-Chloro-2,5-dimethylpyrazine,93%
  • 95-89-6
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  • HETERO CHLORIDE
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  • Halogenated Heterocycles
  • Mono- & Polyalkylpyrazines
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