4-Biphenylacetic acid

Product Name: 4-Biphenylacetic acid
CAS No.: 5728-52-9
Chemical Name: 4-Biphenylacetic acid
Synonyms: FELBINAC;Napageln;BIPHENYL-4-ACETIC ACID;[1,1'-BIPHENYL]-4-ACETIC ACID;2-([1,1'-biphenyl]-4-yl)acetic acid;L-141;TraxaM;LY-61017;Seltouch;CI 83544
CBNumber: CB0186272
Molecular Formula: C14H12O2
Formula Weight: 212.24
MOL File: 5728-52-9.mol

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4-Biphenylacetic acid Property

Melting point:: 159-160 °C (lit.)
Boiling point:: 312.08°C (rough estimate)
Density: 1.1035 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: 2-8°C
solubility: DMSO: soluble50mg/mL, clear, colorless to yellow
form: Powder
pka: 4.29±0.10(Predicted)
color: Beige
Water Solubility: 39.27mg/L(25 ºC)
Merck: 14,3316
BRN: 1211592
InChI: InChI=1S/C14H12O2/c15-14(16)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9H,10H2,(H,15,16)
InChIKey: QRZAKQDHEVVFRX-UHFFFAOYSA-N
SMILES: C1(C2=CC=CC=C2)=CC=C(CC(O)=O)C=C1
CAS DataBase Reference: 5728-52-9(CAS DataBase Reference)

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Safety

Hazard Codes: T,Xn
Risk Statements: 23/25-36/37/38-25-36/37/38/63-20/21/22
Safety Statements: 26-36/37/39-45-37/39-28A-26/36/3745/60-20-36
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: DU8229050
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29163900
Toxicity: LD50 orally in rats: 164 mg/kg (Sloboda, Osterberg)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000731
Product name: Felbinac
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 10 mg
Price: $159
Updated: 2025/07/31

Sigma-Aldrich

Product number: 196487
Product name: 4-Biphenylacetic acid
Purity: 98%
Packaging: 5g
Price: $43.47
Updated: 2025/07/31

Sigma-Aldrich

Product number: 196487
Product name: 4-Biphenylacetic acid
Purity: 98%
Packaging: 25g
Price: $120
Updated: 2023/01/07

TCI Chemical

Product number: B1278
Product name: 4-Biphenylacetic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: B1278
Product name: 4-Biphenylacetic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 250g
Price: $232
Updated: 2025/07/31

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4-Biphenylacetic acid Chemical Properties,Usage,Production

Description

Felbinac Is the active metabolite of the non-steroidal antiinflammatory agent, fenbufen. Applied topically as a gel to joints, it is useful in the symptomatic relief of articular inflammation and pain.

Chemical Properties

Off-white powder

Originator

Lederle (USA)

Uses

Anti-inflammatory, analgesic drug.

Uses

4-Biphenylacetic acid was used in the synthesis of gastrosparing non-steroidal antiinflammatory drug.

Definition

ChEBI: Biphenyl-4-ylacetic acid is a monocarboxylic acid in which one of the alpha-hydrogens is substituted by a biphenyl-4-yl group. An active metabolite of fenbufen, it is used as a topical medicine to treat muscle inflammation and arthritis. It has a role as a non-steroidal anti-inflammatory drug. It is a member of biphenyls and a monocarboxylic acid. It contains a biphenyl-4-yl group. It is functionally related to an acetic acid.

brand name

Dolinac (Wyeth-Ayerst); Flexfree(Wyeth-Ayerst); Napageln (Wyeth-Ayerst); Target (Wyeth-Ayerst); Traxam (Wyeth-Ayerst).

General Description

4-Biphenylacetic acid is a potential non-steroidal antiinflammatory agent and forms solid inclusion complex with β-cyclodextrin. 4-Biphenylacetic acid on interaction with quinolone antibacterial agents induces functional blockade of the γ-aminobutyric acid receptors.

Safety Profile

Poison by subcutaneous route.Moderately toxic by ingestion and intraperitoneal routes.An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits acrid smoke and fumes.

Synthesis

First 4-aminophenylacetic acid is prepared by reducing 4-nitrophenylacetic acid in the presence of a palladium-carbon catalyst; 4-Biphenylacetic acid is finally prepared by reacting 4-aminophenylacetic acid with benzene in the presence of sodium nitrite and an acid.

4-Biphenylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Biphenylacetic acid Suppliers

Americas 1 Australia 1 Austria 1 Belgium 4 Canada 5 China 368 Europe 5 France 2 Germany 10 India 27 Italy 1 Japan 10 Poland 1 Slovakia 1 South Korea 6 Switzerland 3 The Netherlands 1 Turkey 1 Ukraine 1 United Arab Emirates 1 United Kingdom 21 United States 56 Global 527

LEHVOSS UK / Gee Lawson Chemical Division

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View Lastest Price from 4-Biphenylacetic acid manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: 4-Biphenylacetic acid 5728-52-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 20tongs
Release date: 2025-08-21

Shaanxi Dideu New Materials Co. Ltd

Product: 4-Biphenylacetic acid 5728-52-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-12

Taizhou Creating Bio-pharm co., ltd.

Product: 4-Biphenylacetic acid 5728-52-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 20TONS
Release date: 2025-06-06

5728-52-9, 4-Biphenylacetic acidRelated Search:

Phenylacetic acid 4-Biphenylcarboxylic acid Xenyhexenic felbinacethyl cicloprofen xenbucin FLURBIPROFEN AXETIL (R)-(-)-2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID 2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID FLURBIPROFEN SODIUM (200 MG) Namoxyrate butixirate (S)-Flurbiprofen 2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID 4-Biphenylacetic acid BIFEPROFEN 2',4'-difluorobiphenyl-4-acetic acid Fluprofen

4-BIPHENYLACETICABID

Biphenyl-4-acetic acid 97%

4-Biphenylacetic acid/Felbinac

4 -BIPHENYLACETIC ACID 99% BP GRADE

4-BIPHENYL ACETIC ACID 98.5%

4-BIPHENYLACETIC ACID(METHOXYMETHYL)-1,1''-BIPHENYL

Napageln

4-Biphenylacetic acid ,99%

L-141

LJC-10141

LY-61017

4-Biphenylacetic aci

4-BIPHENYLYLACETIC ACID

P-BIPHENYLYLACETIC ACID

(Biphenyl-4-yl)acetic acid 97%

4-Biphenylacetic acid, 98% 10GR

NSC 16284

Seltouch

TraxaM

4-BIPHENYLYLACETIC ACID FOR SYNTHESIS

Biphenyl acetic acid(Felbinac)

2-([1,1'-biphenyl]-4-yl)acetic acid

Biphenyl-4-yl-acetic acid

BIPHENYL-4-ACETIC ACID

FELBINAC

CI 83544

4-PHENYLPHENYLACETIC ACID

4-CARBOXYMETHYLBIPHENYL

4-BIPHENYLACETIC ACID

[1,1'-BIPHENYL]-4-ACETIC ACID

4-Diphenylacetic Acid

P-BIPHENYLACETIC ACID

RARECHEM AL BO 0343

Felbinac(4-BiphenylaceticAcid)

4-Biphenylaceticacid,98+%

biphenyl acetic acide

4-biphenyl acetic acide

4-bisphenylacetic acid ( Felbinac）

Flurbiprofen-d3 (2-Fluoro-a-trideuteromethyl-[1,1&rsquo

Felbinac CRS

4-Biphenylacetic Acid &gt

4-Biphenylessigsaeure

Talc 14807-96-6

Biphenyl monoacetic acid

Felbinac Crude

4-Biphenylacetic Methyl Ether

4-Biphenylacetic Acid, ≥ 97.0%

Felbinac, 10 mM in DMSO

biphenyl-4-ylaceticaci

2-(Biphenyl-4-yl)-acetic acid

5728-52-9

57285-52-9

572-52-9

40728-52-9

C14H11O2

C6H5C6H4CH2CO2H

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