ChemicalBook > CAS DataBase List > 4-Biphenylacetic acid

4-Biphenylacetic acid

Product Name
4-Biphenylacetic acid
CAS No.
5728-52-9
Chemical Name
4-Biphenylacetic acid
Synonyms
FELBINAC;Napageln;BIPHENYL-4-ACETIC ACID;[1,1'-BIPHENYL]-4-ACETIC ACID;2-([1,1'-biphenyl]-4-yl)acetic acid;L-141;TraxaM;LY-61017;Seltouch;CI 83544
CBNumber
CB0186272
Molecular Formula
C14H12O2
Formula Weight
212.24
MOL File
5728-52-9.mol
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4-Biphenylacetic acid Property

Melting point:
159-160 °C (lit.)
Boiling point:
312.08°C (rough estimate)
Density 
1.1035 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: soluble50mg/mL, clear, colorless to yellow
form 
Powder
pka
4.29±0.10(Predicted)
color 
Beige
Water Solubility 
39.27mg/L(25 ºC)
Merck 
14,3316
BRN 
1211592
InChI
InChI=1S/C14H12O2/c15-14(16)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9H,10H2,(H,15,16)
InChIKey
QRZAKQDHEVVFRX-UHFFFAOYSA-N
SMILES
C1(C2=CC=CC=C2)=CC=C(CC(O)=O)C=C1
CAS DataBase Reference
5728-52-9(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xn
Risk Statements 
23/25-36/37/38-25-36/37/38/63-20/21/22
Safety Statements 
26-36/37/39-45-37/39-28A-26/36/3745/60-20-36
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
DU8229050
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
III
HS Code 
29163900
Toxicity
LD50 orally in rats: 164 mg/kg (Sloboda, Osterberg)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0000731
Product name
Felbinac
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
10 mg
Price
$159
Updated
2025/07/31
Sigma-Aldrich
Product number
196487
Product name
4-Biphenylacetic acid
Purity
98%
Packaging
5g
Price
$43.47
Updated
2025/07/31
Sigma-Aldrich
Product number
196487
Product name
4-Biphenylacetic acid
Purity
98%
Packaging
25g
Price
$120
Updated
2023/01/07
TCI Chemical
Product number
B1278
Product name
4-Biphenylacetic Acid
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$41
Updated
2025/07/31
TCI Chemical
Product number
B1278
Product name
4-Biphenylacetic Acid
Purity
>98.0%(HPLC)(T)
Packaging
250g
Price
$232
Updated
2025/07/31
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4-Biphenylacetic acid Chemical Properties,Usage,Production

Description

Felbinac Is the active metabolite of the non-steroidal antiinflammatory agent, fenbufen. Applied topically as a gel to joints, it is useful in the symptomatic relief of articular inflammation and pain.

Chemical Properties

Off-white powder

Originator

Lederle (USA)

Uses

Anti-inflammatory, analgesic drug.

Uses

4-Biphenylacetic acid was used in the synthesis of gastrosparing non-steroidal antiinflammatory drug.

Definition

ChEBI: Biphenyl-4-ylacetic acid is a monocarboxylic acid in which one of the alpha-hydrogens is substituted by a biphenyl-4-yl group. An active metabolite of fenbufen, it is used as a topical medicine to treat muscle inflammation and arthritis. It has a role as a non-steroidal anti-inflammatory drug. It is a member of biphenyls and a monocarboxylic acid. It contains a biphenyl-4-yl group. It is functionally related to an acetic acid.

brand name

Dolinac (Wyeth-Ayerst); Flexfree(Wyeth-Ayerst); Napageln (Wyeth-Ayerst); Target (Wyeth-Ayerst); Traxam (Wyeth-Ayerst).

General Description

4-Biphenylacetic acid is a potential non-steroidal antiinflammatory agent and forms solid inclusion complex with β-cyclodextrin. 4-Biphenylacetic acid on interaction with quinolone antibacterial agents induces functional blockade of the γ-aminobutyric acid receptors.

Safety Profile

Poison by subcutaneous route.Moderately toxic by ingestion and intraperitoneal routes.An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits acrid smoke and fumes.

Synthesis

First 4-aminophenylacetic acid is prepared by reducing 4-nitrophenylacetic acid in the presence of a palladium-carbon catalyst; 4-Biphenylacetic acid is finally prepared by reacting 4-aminophenylacetic acid with benzene in the presence of sodium nitrite and an acid.

4-Biphenylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Biphenylacetic acid manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.
Product
4-Biphenylacetic acid 5728-52-9
Price
US $0.00/kg
Min. Order
1kg
Purity
99%min
Supply Ability
20tongs
Release date
2025-08-21
Shaanxi Dideu New Materials Co. Ltd
Product
4-Biphenylacetic acid 5728-52-9
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-06-12
Taizhou Creating Bio-pharm co., ltd.
Product
4-Biphenylacetic acid 5728-52-9
Price
US $0.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
20TONS
Release date
2025-06-06

5728-52-9, 4-Biphenylacetic acidRelated Search:

Phenylacetic acid 4-Biphenylcarboxylic acid Xenyhexenic felbinacethyl cicloprofen xenbucin FLURBIPROFEN AXETIL (R)-(-)-2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID 2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID FLURBIPROFEN SODIUM (200 MG) Namoxyrate butixirate (S)-Flurbiprofen 2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID 4-Biphenylacetic acid BIFEPROFEN 2',4'-difluorobiphenyl-4-acetic acid Fluprofen

  • 4-BIPHENYLACETICABID
  • Biphenyl-4-acetic acid 97%
  • 4-Biphenylacetic acid/Felbinac
  • 4 -BIPHENYLACETIC ACID 99% BP GRADE
  • 4-BIPHENYL ACETIC ACID 98.5%
  • 4-BIPHENYLACETIC ACID(METHOXYMETHYL)-1,1''-BIPHENYL
  • Napageln
  • 4-Biphenylacetic acid ,99%
  • L-141
  • LJC-10141
  • LY-61017
  • 4-Biphenylacetic aci
  • 4-BIPHENYLYLACETIC ACID
  • P-BIPHENYLYLACETIC ACID
  • (Biphenyl-4-yl)acetic acid 97%
  • 4-Biphenylacetic acid, 98% 10GR
  • NSC 16284
  • Seltouch
  • TraxaM
  • 4-BIPHENYLYLACETIC ACID FOR SYNTHESIS
  • Biphenyl acetic acid(Felbinac)
  • 2-([1,1'-biphenyl]-4-yl)acetic acid
  • Biphenyl-4-yl-acetic acid
  • BIPHENYL-4-ACETIC ACID
  • FELBINAC
  • CI 83544
  • 4-PHENYLPHENYLACETIC ACID
  • 4-CARBOXYMETHYLBIPHENYL
  • 4-BIPHENYLACETIC ACID
  • [1,1'-BIPHENYL]-4-ACETIC ACID
  • 4-Diphenylacetic Acid
  • P-BIPHENYLACETIC ACID
  • RARECHEM AL BO 0343
  • Felbinac(4-BiphenylaceticAcid)
  • 4-Biphenylaceticacid,98+%
  • biphenyl acetic acide
  • 4-biphenyl acetic acide
  • 4-bisphenylacetic acid ( Felbinac）
  • Flurbiprofen-d3 (2-Fluoro-a-trideuteromethyl-[1,1&rsquo
  • Felbinac CRS
  • 4-Biphenylacetic Acid &gt
  • 4-Biphenylessigsaeure
  • Talc 14807-96-6
  • Biphenyl monoacetic acid
  • Felbinac Crude
  • 4-Biphenylacetic Methyl Ether
  • 4-Biphenylacetic Acid, ≥ 97.0%
  • Felbinac, 10 mM in DMSO
  • biphenyl-4-ylaceticaci
  • 2-(Biphenyl-4-yl)-acetic acid
  • 5728-52-9
  • 57285-52-9
  • 572-52-9
  • 40728-52-9
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