ChemicalBook > CAS DataBase List > 4-Biphenylacetic acid

4-Biphenylacetic acid

Product Name
4-Biphenylacetic acid
CAS No.
5728-52-9
Chemical Name
4-Biphenylacetic acid
Synonyms
FELBINAC;Napageln;BIPHENYL-4-ACETIC ACID;[1,1'-BIPHENYL]-4-ACETIC ACID;2-([1,1'-biphenyl]-4-yl)acetic acid;L-141;TraxaM;LY-61017;Seltouch;CI 83544
CBNumber
CB0186272
Molecular Formula
C14H12O2
Formula Weight
212.24
MOL File
5728-52-9.mol
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4-Biphenylacetic acid Property

Melting point:
159-160 °C (lit.)
Boiling point:
312.08°C (rough estimate)
Density 
1.1035 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: soluble50mg/mL, clear, colorless to yellow
form 
Powder
pka
4.29±0.10(Predicted)
color 
Beige
Water Solubility 
39.27mg/L(25 ºC)
Merck 
14,3316
BRN 
1211592
InChI
InChI=1S/C14H12O2/c15-14(16)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9H,10H2,(H,15,16)
InChIKey
QRZAKQDHEVVFRX-UHFFFAOYSA-N
SMILES
C1(C2=CC=CC=C2)=CC=C(CC(O)=O)C=C1
CAS DataBase Reference
5728-52-9(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xn
Risk Statements 
23/25-36/37/38-25-36/37/38/63-20/21/22
Safety Statements 
26-36/37/39-45-37/39-28A-26/36/3745/60-20-36
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
DU8229050
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
III
HS Code 
29163900
Toxicity
LD50 orally in rats: 164 mg/kg (Sloboda, Osterberg)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
196487
Product name
4-Biphenylacetic acid
Purity
98%
Packaging
5g
Price
$60.2
Updated
2024/03/01
Sigma-Aldrich
Product number
196487
Product name
4-Biphenylacetic acid
Purity
98%
Packaging
25g
Price
$120
Updated
2023/01/07
TCI Chemical
Product number
B1278
Product name
4-Biphenylacetic Acid
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$41
Updated
2024/03/01
TCI Chemical
Product number
B1278
Product name
4-Biphenylacetic Acid
Purity
>98.0%(HPLC)(T)
Packaging
250g
Price
$232
Updated
2024/03/01
Alfa Aesar
Product number
A11749
Product name
4-Biphenylacetic acid, 98%
Packaging
50g
Price
$151
Updated
2023/06/20
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4-Biphenylacetic acid Chemical Properties,Usage,Production

Description

Felbinac Is the active metabolite of the non-steroidal antiinflammatory agent, fenbufen. Applied topically as a gel to joints, it is useful in the symptomatic relief of articular inflammation and pain.

Chemical Properties

Off-white powder

Originator

Lederle (USA)

Uses

Anti-inflammatory, analgesic drug.

Uses

4-Biphenylacetic acid was used in the synthesis of gastrosparing non-steroidal antiinflammatory drug.

Definition

ChEBI: Biphenyl-4-ylacetic acid is a monocarboxylic acid in which one of the alpha-hydrogens is substituted by a biphenyl-4-yl group. An active metabolite of fenbufen, it is used as a topical medicine to treat muscle inflammation and arthritis. It has a role as a non-steroidal anti-inflammatory drug. It is a member of biphenyls and a monocarboxylic acid. It contains a biphenyl-4-yl group. It is functionally related to an acetic acid.

brand name

Dolinac (Wyeth-Ayerst); Flexfree(Wyeth-Ayerst); Napageln (Wyeth-Ayerst); Target (Wyeth-Ayerst); Traxam (Wyeth-Ayerst).

General Description

4-Biphenylacetic acid is a potential non-steroidal antiinflammatory agent and forms solid inclusion complex with β-cyclodextrin. 4-Biphenylacetic acid on interaction with quinolone antibacterial agents induces functional blockade of the γ-aminobutyric acid receptors.

Safety Profile

Poison by subcutaneous route.Moderately toxic by ingestion and intraperitoneal routes.An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits acrid smoke and fumes.

4-Biphenylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Biphenylacetic acid Suppliers

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View Lastest Price from 4-Biphenylacetic acid manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
4-Biphenylacetic acid 5728-52-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-08
Hebei Zhuanglai Chemical Trading Co Ltd
Product
4-Biphenylacetic acid 5728-52-9
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-04
WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-Biphenylacetic acid 5728-52-9
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
1000kg
Release date
2021-09-16

5728-52-9, 4-Biphenylacetic acidRelated Search:

Phenylacetic acid 4-Biphenylcarboxylic acid Xenyhexenic felbinacethyl cicloprofen xenbucin FLURBIPROFEN AXETIL (R)-(-)-2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID 2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID FLURBIPROFEN SODIUM (200 MG) Namoxyrate butixirate (S)-Flurbiprofen 2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID 4-Biphenylacetic acid BIFEPROFEN 2',4'-difluorobiphenyl-4-acetic acid Fluprofen

  • 4-BIPHENYLACETICABID
  • Biphenyl-4-acetic acid 97%
  • 4-Biphenylacetic acid/Felbinac
  • 4 -BIPHENYLACETIC ACID 99% BP GRADE
  • 4-BIPHENYL ACETIC ACID 98.5%
  • 4-BIPHENYLACETIC ACID(METHOXYMETHYL)-1,1''-BIPHENYL
  • Napageln
  • 4-Biphenylacetic acid ,99%
  • L-141
  • LJC-10141
  • LY-61017
  • 4-Biphenylacetic aci
  • 4-BIPHENYLYLACETIC ACID
  • P-BIPHENYLYLACETIC ACID
  • (Biphenyl-4-yl)acetic acid 97%
  • 4-Biphenylacetic acid, 98% 10GR
  • NSC 16284
  • Seltouch
  • TraxaM
  • 4-BIPHENYLYLACETIC ACID FOR SYNTHESIS
  • Biphenyl acetic acid(Felbinac)
  • 2-([1,1'-biphenyl]-4-yl)acetic acid
  • Biphenyl-4-yl-acetic acid
  • BIPHENYL-4-ACETIC ACID
  • FELBINAC
  • CI 83544
  • 4-PHENYLPHENYLACETIC ACID
  • 4-CARBOXYMETHYLBIPHENYL
  • 4-BIPHENYLACETIC ACID
  • [1,1'-BIPHENYL]-4-ACETIC ACID
  • 4-Diphenylacetic Acid
  • P-BIPHENYLACETIC ACID
  • RARECHEM AL BO 0343
  • Felbinac(4-BiphenylaceticAcid)
  • 4-Biphenylaceticacid,98+%
  • biphenyl acetic acide
  • 4-biphenyl acetic acide
  • 4-bisphenylacetic acid ( Felbinac）
  • Flurbiprofen-d3 (2-Fluoro-a-trideuteromethyl-[1,1&rsquo
  • Felbinac CRS
  • 4-Biphenylacetic Acid &gt
  • 4-Biphenylessigsaeure
  • Talc 14807-96-6
  • Biphenyl monoacetic acid
  • Felbinac Crude
  • 4-Biphenylacetic Methyl Ether
  • 4-Biphenylacetic Acid, ≥ 97.0%
  • Felbinac, 10 mM in DMSO
  • 5728-52-9
  • 57285-52-9
  • 572-52-9
  • 40728-52-9
  • C14H11O2
  • C6H5C6H4CH2CO2H
  • Organic Building Blocks
  • Building Blocks
  • C13 to C42+
  • Carbonyl Compounds