2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one

Product Name: 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one
CAS No.: 27277-00-5
Chemical Name: 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one
Synonyms: ICI 63197;PP-796 emetic;Triazolopyrimidinones;ICI 63,197 >=98% (HPLC);AMINOPROPYLTRIAZOLOPYRIMIDONE;2-AMINO-6-METHYL-4-PROPYL-4H-[1,2,4]TRIAZOLO-[1,5-;2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one;2-Amio-6-methyl-4-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-...;2-azanyl-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one;2-AMINO-6-METHYL-4-PROPYL-[1,2,4]TRIAZOLO[1,5- AJPYRIMIDIN-5-ONE
CBNumber: CB0191331
Molecular Formula: C9H13N5O
Formula Weight: 207.23
MOL File: 27277-00-5.mol

More

Less

2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one Property

Melting point:: 161.8-163 °C
Boiling point:: 459.9±28.0 °C(Predicted)
Density: 1.44±0.1 g/cm3(Predicted)
vapor pressure: 0.004Pa at 25℃
storage temp.: 2-8°C
solubility: DMSO: 13 mg/mL
pka: 2.96±0.40(Predicted)
form: solid
color: white
Water Solubility: 5.7g/L at 20℃
InChIKey: UQDVRVNMIJAGRK-UHFFFAOYSA-N
LogP: 0.49 at 20℃
CAS DataBase Reference: 27277-00-5(CAS DataBase Reference)
EPA Substance Registry System: 2-Amino-4,5-dihydro-6-methyl-4-propyl-s-triazolo-(1,5-a)-pyrimidin-5-one (27277-00-5)

More

Less

Safety

RIDADR: 2811
WGK Germany: 1
HazardClass: 6.1(b)
PackingGroup: III

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I8283
Product name: ICI 63,197
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $207
Updated: 2024/03/01

Sigma-Aldrich

Product number: I8283
Product name: ICI 63,197
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $814
Updated: 2024/03/01

Usbiological

Product number: 255484
Product name: ICI 63197
Packaging: 10mg
Price: $403
Updated: 2021/12/16

TRC

Product number: I163888
Product name: ICI 63,197
Packaging: 250mg
Price: $305
Updated: 2021/12/16

TRC

Product number: I163888
Product name: ICI 63,197
Packaging: 25mg
Price: $185
Updated: 2021/12/16

More

Less

2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one Chemical Properties,Usage,Production

Uses

ICI 63197 is a specific cAMP phosphodiesterase (PDE) inhibitor. It is potent in anatagonizing reserpine-induced hypothermia. potent PDE4 inhibitor.

Definition

ChEBI: 2-amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one is a member of triazolopyrimidines.

Flammability and Explosibility

Not classified

Biological Activity

Potent phosphodiesterase (PDE) 4 inhibitor (IC 50 = 35 nM for inhibition of [ 3 H]-rolipram binding to rat brain). Antidepressant following systemic administration in vivo .

Biochem/physiol Actions

Phosphodiesterase IV (PDE 4) inhibitor

storage

+4°C

2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one Suppliers

China 127 Germany 3 India 1 Switzerland 1 United Kingdom 1 United States 20 USA 1 Global 154

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

American Custom Chemicals Corporation

Tel: --
Fax: --
Email: sales@acccorporation.com
Country: United States
ProdList: 6820
Advantage: 51

Amfinecom Inc.

Tel: --
Fax: --
Email: sales@amfinecom.com
Country: United States
ProdList: 3062
Advantage: 50

Wonda Science

Tel: --
Fax: --
Email: wonda@wondascience.com
Country: United States
ProdList: 2192
Advantage: 50

Ontario Chemicals, Inc

Tel: --
Fax: --
Email: info@ontariochem.com
Country: United States
ProdList: 723
Advantage: 50

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

OChem Incorporation

Tel: --
Fax: --
Email: sales@ocheminc.com
Country: United States
ProdList: 6501
Advantage: 60

AmplaChem, Inc.

Tel: --
Fax: --
Email: info@amplacheminc.com
Country: United States
ProdList: 428
Advantage: 50

Santa Cruz Biotechnology, Inc.

Tel: --
Fax: --
Email: scbt@scbt.com
Country: United States
ProdList: 3597
Advantage: 60

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

Chiral Management

Tel: --
Fax: --
Email: sales@chiralmanagement.com
Country: United States
ProdList: 1332
Advantage: 30

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

BOSCHE SCIENTIFIC, LLC

Tel: --
Fax: --
Email: Sales@BoscheSci.com
Country: United States
ProdList: 6477
Advantage: 55

More

Less

View Lastest Price from 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one manufacturers

Dideu Industries Group Limited

Product: 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one 27277-00-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-17

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one 27277-00-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one 27277-00-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-23

27277-00-5, 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-oneRelated Search:

Kresoxim-methyl Tris(hydroxymethyl)aminomethane Cyclopropyl methyl ketone Sulfamerazine Propyl gallate N,N-Dimethyl-1,4-phenylenediamine 3-Methyl-2-butanone Pirimiphos-methyl Methylparaben Methanol Acetonitrile Paraquat dichloride Methyl acrylate Propyl butyrate Basic Violet 1 Methyl 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one

2-AMINO-6-METHYL-4-PROPYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-5(4H)-ONE

2-AMINO-6-METHYL-4-PROPYL-4H-[1,2,4] TRIAZOLE-[1,5-A] PYRIMIDINE-5-ONE

2-AMINO-6-METHYL-4-PROPYL-4H-[1,2,4]TRIAZOLO-[1,5-A]PYRIMIDIN-5-ONE

2-AMINO-6-METHYL-5-OXO-4-N-PROPYL-4,5-DIHYDRO-S-TRIAZOLE[1,5-A]PYRIMIDINE

ICI 63197

2,4]triazolo[1,5-a]pyrimidin-5(4h)-one,2-amino-6-methyl-4-propyl-[

2-Amio-6-methyl-4-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one

2-AMINO-6-METHYL-5-OXO-4-N-PROPYL-4,5-DIHYDRO-S-TRIAZOLE[1,5-α]PYRIMIDIN

AMINOPROPYLTRIAZOLOPYRIMIDONE

2-AMINO-6-METHYL-4-PROPYL-4H-[1,2,4] TRIAZOLE-[1,5-A] PYRIMIDONE-5-ONE

PP796,2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one

1,2,4Triazolo1,5-apyrimidin-5(4H)-one, 2-amino-6-methyl-4-propyl-

2-AMINO-6-METHYL-5-OXO-4-N-PROPYL-4,5-DIHYDRO-S-TRIAZOLE[1,5- A ] PYRIMIDIN

2-AMINO-6-METHYL-4-PROPYL-4H-[1,2,4]TRIAZOLE-[1,5-ALPHA]PYRIMIDONE-5-ONE

2-AMINO-4,5-DIHYDRO-6-METHYL-4-PROPYL-S-TRIAZOLO(1,5-ALPHA)PYRIMIDIN-5-ONE

2-Amino-6-methyl-4-propyl-1,2,4-triazolo[1,5-a]pyrimidin-5(4H)-on

2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one

2-AMINO-6-METHYL-5-OXO-4-N-PROPYL-4,5-DIHYDRO-S-TRIAZOLE[1,5-ALPHA]PYRIMIDIN

PP-796 emetic

2-Amino-6-methyl-4-propyl-4,5-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-5-one

2-azanyl-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one

ICI 63,197,2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one

2-aMino-6-Methyl-4-propyl-4H,5H-[1,2,4]triazolo[1,5-a]pyriMidin-5-one

2-Amino-4,5-dihydro-6-methyl-4-propyl-s-triazolo-(1,5-A)-pyrimidin-5-one Caswell No. 033E

2-Amino-6-methyl-4-propyl-1,2,4-triazolo(1,5-a)pyrimidin-5(4H)-one 2-Amino-6-methyl-5-oxo-4n-propyl-4,5-dihydro-s-triazolo(1,5-a)pyrimidine 2-Amino-4,5-dihydro-6-methyl-4-propyl-5-triazolo-(1,5-c)-pyramidin-5-one 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one

ICI 63,197 >=98% (HPLC)

2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one USP/EP/BP

2-AMINO-6-METHYL-4-PROPYL-4H-[1,2,4]TRIAZOLO-[1,5-

2-Amio-6-methyl-4-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-...

Triazolopyrimidinones

2-AMINO-6-METHYL-4-PROPYL-[1,2,4]TRIAZOLO[1,5- AJPYRIMIDIN-5-ONE

27277-00-5

C3H13F5O

C9H13N5O

Biochemicals and Reagents

BioChemical

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors by Enzyme

Enzyme Inhibitors

Phosphodiesterase IV

P to Q

Cyclic Nucleotide related