Calcium levofolinate

ChemicalBook > CAS DataBase List > Calcium levofolinate

Calcium levofolinate

Definition Uses Pharmaceutical Applications Indications Preparation

Product Name: Calcium levofolinate
CAS No.: 80433-71-2
Chemical Name: Calcium levofolinate
Synonyms: levofolinate;levoleucovorin calcium;Calcium Levofolinate Pentahydrate;Elvorine;Isovorin;CL 307782;Calcium leovate;Levofolinatecalcium;l-Form calcium salt;CALCIUM LEVOFOLINATE
CBNumber: CB0193805
Molecular Formula: C20H25CaN7O7
Formula Weight: 515.54
MOL File: 80433-71-2.mol

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Calcium levofolinate Property

Melting point:: 240-2500C (dec)
alpha: D20 -15.1° (c = 1.82)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: Slightly soluble in water, practically insoluble in acetone and in ethanol (96 per cent).
form: Solid
color: Off-White to Pale Beige
Stability:: Hygroscopic, Light Sensitive
CAS DataBase Reference: 80433-71-2(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23833
Product name: L-Folinic Acid (calcium salt)
Purity: ≥98%
Packaging: 250mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 23833
Product name: L-Folinic Acid (calcium salt)
Purity: ≥98%
Packaging: 500mg
Price: $176
Updated: 2024/03/01

Cayman Chemical

Product number: 23833
Product name: L-Folinic Acid (calcium salt)
Purity: ≥98%
Packaging: 1g
Price: $330
Updated: 2024/03/01

Usbiological

Product number: 269305
Product name: Calcium levofolinate
Packaging: 250mg
Price: $403
Updated: 2021/12/16

TRC

Product number: C145635
Product name: CalciumLevofolinate
Packaging: 100mg
Price: $150
Updated: 2021/12/16

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Calcium levofolinate Chemical Properties,Usage,Production

Definition

Calcium levofolinate is the calcium salt of levofolinic acid, levofolinic acid is an isomer of 5-formyltetrahydrofolate (ie folinic acid), and another form of folinic acid is dl-LV. The Calcium levofolinate in the body cannot be used, just to delay the metabolism of LV in the body, make it persist for a long time, and reduce the metabolic pathway of L-LV in the body, and weaken the effect of L-LV.

Uses

Calcium L-leucovorin is a new anti-tumor drug, mainly used to treat osteosarcoma after high-dose methotrexate treatment and the symptoms related to folic acid antagonism. Levoleucovorin can also be used to treat giant cell anemia caused by folic acid deficiency. It can also be used in combination with fluorouracil to prolong the survival of patients with advanced colon cancer or relieve symptoms.

Pharmaceutical Applications

Levoleucovorin is the biologically active substance of calcium folinate, and calcium folinate is a diastereomeric mixture of 5-formyl derivatives of tetrahydrofolate (THF). Calcium folinate does not need to be reduced by dihydrofolate reductase to directly participate in the biological reaction using folic acid as a carrier for transferring one-carbon groups in the body. L-leucovorin (L-5 leucovorin) is rapidly metabolized (5,10-methyltetrahydrofolate, 5,10-leucovorin tetrahydrofolate) to L-5-methyltetrahydrofolate. L-5-methyltetrahydrofolate can be metabolized into 5,10-methylenetetrahydrofolate through other pathways of , and 5,10-methylenetetrahydrofolate is irreversibly converted through the catalytic reduction of PDAH2 and NADPH coenzymes. It is 5-methyltetrahydrofolate. The use of folinic acid can counteract the therapeutic effects and toxicity of hydrochloric acid antagonists that inhibit dihydrofolate reductase (such as methotrexate). Leucovorin can also enhance the efficacy and toxicity of fluoropyrimidine (such as 5-fluorouracil) in tumor treatment. Simultaneous use of folinic acid does not change the pharmacokinetic process of 5-fluorouracil in plasma.

Indications

Levoleucovorin calcium is mainly used as an adjuvant drug for tumor chemotherapy in addition to megaloblastic anemia caused by various reasons. (1) The rescue therapy of high-dose methotrexate combined with levofolinate calcium is used to counter the resistance of tumor cells to methotrexate, and it can also antagonize the toxicity of methotrexate to normal cells; (2) Left sub The combination of calcium folic acid and 5‑Fu enhances its therapeutic effect and prolongs the survival time of palliative treatment of advanced colorectal cancer.

Preparation

1) Add tetrahydrofolate, a reduction product of raw material folic acid, to formic acid for formylation with trifluoroacetic acid as a catalyst, and place it at a temperature of 10°C-30°C (room temperature) for 10-24 hours Afterwards, 5,10-methylenetetrahydrofolate is obtained; then hydrochloric acid is added, so that the formylation intermediate-5,10-methylenetetrahydrofolate is precipitated in the form of hydrochloride;2) Reconstitute the precipitated hydrochloride of 5,10-methylenetetrahydrofolate with formic acid, add hydrochloric acid and recrystallize to precipitate refined products of 5,10-methylenetetrahydrofolate;3) Suspend the recrystallized 5,10-methylenetetrahydrofolate hydrochloride in water, add an aqueous solution of a medium strong base such as piperazine to make a buffer system, and then add a medium strong base such as piperazine or strong Adjust the pH value of the ring-opening reaction system to 5.5-7.5 with an aqueous base such as sodium hydroxide, perform heating to hydrolyze the ring-opening, and directly add anhydrous CaCl2 equal to the weight (w/w) of the intermediate to the solution after ring-opening, and Adjust the pH value to 5.5-8.5, place it, the precipitated solid is calcium levofolinate;4) The precipitated calcium levofolinate is recrystallized with water to obtain a refined product of calcium levofolinate.

Description

L-Folinic acid is a reduced folic acid and isomer of DL-folinic acid . DL-Folinic acid is a racemic mixture of D-folinic acid and L-folinic acid that has been used to prevent toxicity following therapy with high-dose methotrexate , to enhance the antitumor activity of 5-fluorouracil , and as a folate supplement. Clinical studies demonstrate that formulations containing L-folinic acid have similar efficacy and tolerability as those contianing DL-folinic acid and have been used interchangeably for modification of antitumor activity of 5-fluorouracil, while D-folinic acid is inactive.

Chemical Properties

Off-White to Light Beige Amorphous Powder

Uses

It is an intermediate product of the metabolism of Folic Acid; the active form into which that acid is converted in the body, ascorbic acid being a necessary factor in the conversion process.

Uses

Calcium levofolinate is a pharmaceutical drug that is used in biological studies for the treatment of colorectal cancer.

Uses

intermediate from Folic Acid metabolism

Calcium levofolinate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Calcium levofolinate manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Calcium levofolinate 80433-71-2
Price: US $0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-03-27

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Calcium levofolinate 80433-71-2
Price: US $0.00/g
Min. Order: 1g
Purity: 98.0%
Supply Ability: 10kg/month
Release date: 2021-12-17

Hebei Mojin Biotechnology Co., Ltd

Product: Calcium levofolinate 80433-71-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-07

80433-71-2, Calcium levofolinateRelated Search:

Calcium Propionate Folinic acid Calcium carbide Calcium folinate Calcium chloride Calcium dobesilate Calcium phosphate Calcium gluconate Calcium carbonate Folic acid 5,10-Methylene-THF Levofloxacin Zolmitriptan Levetiracetam Zofenopril calcium 10-formyldihydrofolate Calcium Levofolinate EP Impurity E 10-Formylfolic Acid

CALCIUM LEVOFOLINATE

calcium n-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-l-glutamate

levoleucovorin calcium

N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid Calcium Salt

(S)-Leucovorin calcium salt (1:1)

5-Formyl-(6S)-tetrahydrofolate calcium salt

Calcium (6S)-folinate

CL 307782

L-LEUCOVORIN CALCIUM

Levofolinatecalcium

calcium (2S)-2-[[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]phenyl]-oxomethyl]amino]pentanedioate

(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate

Elvorine

Isovorin

L-Folinic acid calcium salt

L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1), (S)-

L-Glutamic acid, N-[4-[[[(6S)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-, calcium salt (1:1) (9CI)

levofolinic acid, calcium salt

levofolinate

CalciuM levofolinate API

Folinic Acid CalciuM (CalciuM Levofolinate)

L-CalciuM Levofolinate

N-[4-[[[(6S)-2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-L-glutamic acid, calcium salt (1:1)

l-Form calcium salt

Calcium Levofolinate Pentahydrate

Levoleucovorin Calcium Pentahydrate (Calcium levofolinate

(6S)-5-Formyl-5,6,7,8-tetrahydrofolic acid, calcium salt (natural calcium folinate)

calcium,(2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate

Calcium levofolinate USP/EP/BP

L-Glutamic acid,N-[4-[[[(6S)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-, calcium salt (1:1)

Calcium Levofolinate ( Calcium levofolinate

Calcium LevofolinateQ: What is Calcium Levofolinate Q: What is the CAS Number of Calcium Levofolinate Q: What is the storage condition of Calcium Levofolinate Q: What are the applications of Calcium Levofolinate

Calcium leovate

Levoleucovorin Calcium/Calcium levofolinate

Levofolinate Calcium?Salt

(4-((((S)-2-Amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid, calcium salt(1:1)

80433-71-2

C20H21N7O7Ca

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