Description
ChemicalBook > CAS DataBase List > L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid

L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid

Description
Product Name
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
CAS No.
74163-81-8
Chemical Name
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
Synonyms
Tic-OH;(S)-TIC;L-TIC HCL;L-1,2,3,4-Tetrahydro;Icatibant Impurity 14;Quinapril Bicyclic Acid;Quinapril EP Impurity A;(S)-1,2,3,4-Tetrahydro-3-isoquinoL;Quinapril Hydrochloride Impurity A;(3S)-1,2,3,4-Tetrahydroisoquinoline
CBNumber
CB0197924
Molecular Formula
C10H11NO2
Formula Weight
177.2
MOL File
74163-81-8.mol
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L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Property

Melting point:
>300 °C(lit.)
alpha 
-157.4 º (24 ºC)
Boiling point:
309.12°C (rough estimate)
Density 
1.1607 (rough estimate)
refractive index 
-166 ° (C=1, 1mol/L NaOH)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
soluble in Hot Water, Basic Water
pka
2.21±0.20(Predicted)
form 
powder to crystal
color 
White to Almost white
optical activity
[α]20/D 168°, c = 1.8 in 1.4 M NaOH
BRN 
4842199
InChIKey
BWKMGYQJPOAASG-VIFPVBQESA-N
CAS DataBase Reference
74163-81-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
HS Code 
29334900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
421626
Product name
(S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid
Purity
97%
Packaging
5g
Price
$25
Updated
2024/03/01
TCI Chemical
Product number
T1515
Product name
(S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid
Purity
>98.0%(T)
Packaging
5g
Price
$72
Updated
2024/03/01
TCI Chemical
Product number
T1515
Product name
(S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid
Purity
>98.0%(T)
Packaging
25g
Price
$208
Updated
2024/03/01
Alfa Aesar
Product number
L14422
Product name
(S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, 97%
Packaging
1g
Price
$23.65
Updated
2024/03/01
Alfa Aesar
Product number
L14422
Product name
(S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, 97%
Packaging
5g
Price
$65.65
Updated
2024/03/01
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L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Chemical Properties,Usage,Production

Description

(S)-(-)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is a quinoline derivative, which is used as an intermediate in the synthesis of quinapril. Quinapril, a product developed by Pfizer, was approved by the US FDA in 1991 for the treatment of hypertension, congestive heart failure and angioedema.

Chemical Properties

white to light yellow crystal powde

Uses

(S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Quinapril EP Impurity A) is a Quinapril intermediate.

L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Suppliers

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View Lastest Price from L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid 74163-81-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-09
Zhuozhou Wenxi import and Export Co., Ltd
Product
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid 74163-81-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
(S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid 74163-81-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

74163-81-8, L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acidRelated Search:

Tetrahydrofuran 1,2,3,4-Tetrahydroquinoline 1,2,3,4-TETRAHYDROISOQUINOLINE Tetramethylammonium hydroxide pentahydrate Isoquinoline Potassium hydrogen phthalate Isoquinoline-1-carboxylic acid 5,6,7,8-TETRAHYDROISOQUINOLINE cis-1,2,3,6-Tetrahydrophthalic anhydride 2-Tetrahydrofuroic acid H-TLE-OTBU HCL H-Tic-OMe·HCl L-tert-Leucine methyl ester hydrochloride H-Tic-OtBu·HCl (S)-6,7-Dimethoxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrochloride Quinapril hydrochloride Moexipril (S)-L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID BENZYL ESTER HYDROCHLORIDE,L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID BENZYL ESTER HYDROCHLORIDE

  • (S)-TIC
  • (S)-N-tert-1,2,3,4-tetrahydroisoquinoline -3-carboxamide
  • L-1,2,3,4-Tetrahydro
  • 4-Tetrahydro-3-Isoquinolinecarboxylic acid
  • [S]-1,2,3,4-Tetrahydro-3-Isoquinolingcarboxylic Acid
  • (S)-1, 2, 3, 4-tetrahydro-3-isoquinolinecarboxylic acid (for Quinapril)
  • L-1,2,3,4-Tetrahydroisoquinoline-3-CarboxylicAcid98%
  • (S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID METHYLESTHER
  • (3S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLICACIDHYDROCHLORIDE
  • L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC
  • (S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxlicacid
  • (S)-1,2,3,4-Tetrahydro-3-isoquinoline-carboxylic aci
  • L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
  • 1,2,3,4-Tetrahydroisoquinoline-3-carboxxylic acid
  • (S)-1,2,3,4-TERTRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID
  • (3S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECA
  • (S)-1,2,3,4-Tetrahydro-3-isoquinoline-carboxylic acid hydrochloride, 95+%
  • (S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylicacid,97%
  • (<i>S</i>)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
  • Quinapril Bicyclic Acid
  • (S)-1,2,3,4-TETRAHYDO-3-ISOQUINOLINECARBOXYLIC ACID HCL
  • (S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID HCL SALT
  • (S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID HYDROCHLORIDE
  • (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID HCL
  • S-(-)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE
  • (3S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid≥ 98% (HPLC)
  • Tic-OH
  • (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid,99%e.e.
  • (3S)-1,2,3,4-Tetrahydro-3-isoquinolinecarbocylic acid for synthesis
  • L-TIC HCL
  • L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE
  • 3-ISOQUINOLINECARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-,(3S)-
  • Quinapril EP Impurity A
  • Quinapril Impurity 1（Quinapril EP Impurity A）
  • (3S)-1,2,3,4-Tetrahydroisoquinoline
  • (S)-1,2,3,4-Tetrahydro-3-isoquinoL
  • [S]-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINGCARBOXYLIC ACID (CAS:74163-81-8)
  • L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid USP/EP/BP
  • (S)-(-) 1,2,3, 4-Tetrahydroisoquinoline -3-Carboxylic Acid pure, 98%
  • (-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
  • Quinapril Hydrochloride EP Impurity A
  • (-)-1,2,3,4-Tetrahydro-isoquinolin-3-carboxylic acid
  • Quinapril Hydrochloride Impurity A
  • Icatibant Impurity 14
  • 74163-81-8
  • Others
  • Peptide Synthesis
  • Unnatural Amino Acid Derivatives
  • Specialty Synthesis
  • Carboxylic Acids
  • (intermediate of quinapril)
  • Carboxylic Acids
  • Quinolines, Isoquinolines & Quinoxalines
  • chiral
  • Amino Acids
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals