enniatin A
- Product Name
- enniatin A
- CAS No.
- 2503-13-1
- Chemical Name
- enniatin A
- Synonyms
- enniatin A;Lateritin I;N-Methylcyclo(L-Ile-D-Hmb-N-methyl-L-Ile-D-Hmb-N-methyl-L-Ile-D-Hmb-);(3S,6R,9S,12R,15S,18R)-3,9,15-tris[(2S)-butan-2-yl]-4,10,16-trimethyl-6,12,18-tri(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone;Cyclo[(2R)- 2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl- N-methyl-L- isoleucyl]
- CBNumber
- CB02079105
- Molecular Formula
- C36H63N3O9
- Formula Weight
- 681.906
- MOL File
- 2503-13-1.mol
enniatin A Property
- Melting point:
- 122-124 °C
- Boiling point:
- 847.4±65.0 °C(Predicted)
- Density
- 1.022±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble10mg/mL
- form
- White to off-white crystalline solid.
- pka
- -0.96±0.70(Predicted)
- biological source
- Gnomonia errabunda
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- E9661
- Product name
- Enniatin A
- Purity
- from Gnomonia errabunda, ≥95% (HPLC)
- Packaging
- 1mg
- Price
- $225
- Updated
- 2025/07/31
- Product number
- 17456
- Product name
- Enniatin A
- Purity
- ≥99%
- Packaging
- 500μg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 17456
- Product name
- Enniatin A
- Purity
- ≥99%
- Packaging
- 2.5mg
- Price
- $816
- Updated
- 2024/03/01
- Product number
- E3222-26
- Product name
- Enniatin A
- Packaging
- 500ug
- Price
- $426
- Updated
- 2021/12/16
- Product number
- E555990
- Product name
- EnnlatinA
- Packaging
- 25mg
- Price
- $11815
- Updated
- 2021/12/16
enniatin A Chemical Properties,Usage,Production
Description
Enniatins are cyclohexadepsipeptides commonly isolated from fungi that are known to have antibiotic properties and to induce apoptosis in several cancer lines. Many function as ionophores, forming pores in cellular membranes to allow selective ion transport. Enniatin A is one of four major analogs in the enniatin complex . It has been shown to moderately inhibit acyl-CoA:cholesterol acyltranferase activity in rat liver microsomes with an IC50 value of 22 μM. Enniatin A also demonstrates anthelmintic properties against N. brasiliensis, T. spiralis, and H. spumosa.
Uses
Enniatins are a family of depsipeptide ionophores, produced by several Fusarium species. More recently, the effects of the enniatins on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumour action have received more focus. Enniatin A is one of four major analogues of the enniatin complex and has not previously been available for investigation.
Uses
Enniatins are a family of depsipeptide ionophores, produced by several Fusarium species. Recently, the effects of the enniatins on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus. Enniatin A is one of four major analogues of the enniatin complex.
Uses
Enniatins are cyclohexadepsipeptides commonly isolated from fungi that are known to have antibiotic properties and to induce apoptosis in several cancer lines. Many function as ionophores, forming pores in cellular membranes to allow selective ion transport. Enniatin A is one of four major analogs in the enniatin complex . It has been shown to moderately inhibit acyl-CoA:cholesterol acyltranferase activity in rat liver microsomes with an IC50 value of 22 μM. Enniatin A also demonstrates anthelmintic properties against N. brasiliensis, T. spiralis, and H. spumosa.[Cayman Chemical]
Definition
ChEBI: An enniatin obtained from formal cyclocondensation of three N-[(2R)-2-hydroxy-3-methylbutanoyl]-N-methyl-L-isoleucine units.
Biochem/physiol Actions
Enniatins are a group of cyclohexadepsipeptide mycotoxins produced by Gnomonia errabuda and several Fusaria species, with phytotoxic, antibiotic, and insecticidal activities. Enniatins function as ionophors by their incorporation into the cellular membrane to form dimeric structures that transport monovalent ions across the membrane (especially the mitochondrial membranes) affecting oxidative phosphorylation uncoupling. It has been demonstrated that enniatins have a cytotoxic effect on human cancer cells. Furthermore, incubation of H4IIE hepatoma cells with enniatins strongly diminished phosphorylation of the ERK (p44/p42).
IC 50
ACAT
References
[1] H TOMODA. Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics.[J]. Journal of Antibiotics, 1992, 45 10: 1626-1632. DOI: 10.7164/antibiotics.45.1626
[2] ARLENE A SY-CORDERO Nicholas H O Cedric J Pearce. Revisiting the enniatins: a review of their isolation, biosynthesis, structure determination and biological activities[J]. Journal of Antibiotics, 2012, 65 11: 541-549. DOI: 10.1038/ja.2012.71
enniatin A Preparation Products And Raw materials
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