2-ETHOXY-4,6-DICHLOROPYRIMIDINE
Application- Product Name
- 2-ETHOXY-4,6-DICHLOROPYRIMIDINE
- CAS No.
- 40758-65-4
- Chemical Name
- 2-ETHOXY-4,6-DICHLOROPYRIMIDINE
- Synonyms
- 4,6-DICHLORO-2-ETHOXYPYRIMIDINE;2-ETHOXY-4,6-DICHLOROPYRIMIDINE;Pyrimidine, 4,6-dichloro-2-ethoxy-
- CBNumber
- CB0208170
- Molecular Formula
- C6H6Cl2N2O
- Formula Weight
- 193.03
- MOL File
- 40758-65-4.mol
2-ETHOXY-4,6-DICHLOROPYRIMIDINE Property
- Boiling point:
- 283.5±43.0 °C(Predicted)
- Density
- 1.375±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -4.46±0.30(Predicted)
- CAS DataBase Reference
- 40758-65-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E940233
- Product name
- 2-Ethoxy-4,6-dichloropyrimidine
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- W6132
- Product name
- 2-Ethoxy-4,6-dichloropyrimidine
- Packaging
- 5g
- Price
- $1388
- Updated
- 2021/12/16
- Product number
- HCH0049704
- Product name
- 2-ETHOXY-4,6-DICHLOROPYRIMIDINE
- Purity
- 95.00%
- Packaging
- 100G
- Price
- $4446.75
- Updated
- 2021/12/16
- Product number
- HCH0049704
- Product name
- 2-ETHOXY-4,6-DICHLOROPYRIMIDINE
- Purity
- 95.00%
- Packaging
- 250G
- Price
- $7738.5
- Updated
- 2021/12/16
- Product number
- A399005
- Product name
- 2-Ethoxy-4,6-dichloropyrimidine
- Purity
- 98%
- Packaging
- 250mg
- Price
- $84
- Updated
- 2021/12/16
2-ETHOXY-4,6-DICHLOROPYRIMIDINE Chemical Properties,Usage,Production
Application
2-Ethoxy-4,6-dichloropyrimidine is an important heterocyclic pesticide and pharmaceutical intermediate. It can be used to synthesize highly effective herbicides containing triazole pyrimidine rings, such as dichlorvos and chlorpyrifos; it can also be used to synthesize certain antibiotics. Therefore, 2-ethoxy-4,6-dichloropyrimidine has broad application prospects in organic synthesis, pharmaceuticals, and pesticides.
Synthesis
141-52-6
4489-34-3
40758-65-4
To a 500 mL reaction flask equipped with a stirrer and thermometer was added 43.5 g of 2-methylsulfonyl-4,6-dichloropyrimidine (0.19 mol) and 90 g of ethanol and stirred at room temperature. The reaction mixture was then cooled to 0 °C and 130 g of sodium ethanol solution (0.38 mol) at a concentration of 20 wt% was slowly added dropwise. Upon completion of the reaction, the reaction was terminated by sampling and analysis to confirm that the feedstock content was less than 1%. After adjusting the reaction system to neutral pH, a small amount of acetic acid was added and ethanol was recovered under reduced pressure. Subsequently, dichloromethane was added, the solvent was evaporated and water was added to separate the organic layer. The organic layer was washed once with water and the first solvent was recovered. 35.2 g of 2-ethoxy-4,6-dichloropyrimidine was obtained in 95.2% yield and 96.5% purity (HPLC analysis) by distillation under reduced pressure until no liquid was exuded.
Toxics Screening Level
The ITSL is being set at the default value of 0.1 μg/m3 with annual averaging.
References
[1] Patent: CN106866547, 2017, A. Location in patent: Paragraph 0021; 0022
2-ETHOXY-4,6-DICHLOROPYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-ETHOXY-4,6-DICHLOROPYRIMIDINE manufacturers
- Product
- 2-Ethoxy-4,6-dichloropyrimidine 40758-65-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-28
- Product
- 2-ethoxy-4,6-dichloropyrimidine 40758-65-4
- Price
- US $0.00/kg
- Min. Order
- 1000kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2025-03-18
- Product
- 2-Ethoxy-4,6-dichloropyrimidine 40758-65-4
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- GC 90.0%
- Supply Ability
- 20tons
- Release date
- 2023-09-08