NU1025

ChemicalBook > CAS DataBase List > NU1025

Product Name: NU1025
CAS No.: 90417-38-2
Chemical Name: NU1025
Synonyms: NU1025;NSC 696807;NU 1025;NU 1025;NU1025 USP/EP/BP;NU1025 (NSC 696807);PARP Inhibitor VI, NU1025;8-Hydroxy-2-methylquinazolin-4(3H);8-HYDROXY-2-METHYLQUINAZOLINE-4-ONE;8-HYDROXY-2-METHYLQUINAZOLIN-4[3H]-ONE;8-HYDROXY-2-METHYL-4(3H)-QUINAZOLINONE
CBNumber: CB0214872
Molecular Formula: C9H8N2O2
Formula Weight: 176.17
MOL File: 90417-38-2.mol

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NU1025 Property

Melting point:: 253-258°C
Boiling point:: 345.4±44.0 °C(Predicted)
Density: 1.42
storage temp.: −20°C
solubility: DMSO: 35 mg/mL, soluble
form: solid
pka: 8.68±0.20(Predicted)
color: off-white
CAS DataBase Reference: 90417-38-2

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 26
WGK Germany: 3
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N7287
Product name: NU-1025
Purity: ≥97% (HPLC), solid
Packaging: 5mg
Price: $210
Updated: 2024/03/01

Sigma-Aldrich

Product number: 493800
Product name: PARP Inhibitor VI, NU1025
Packaging: 5mg
Price: $230
Updated: 2024/03/01

Cayman Chemical

Product number: 14534
Product name: NU 1025
Purity: ≥98%
Packaging: 1mg
Price: $31
Updated: 2024/03/01

Cayman Chemical

Product number: 14534
Product name: NU 1025
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 14534
Product name: NU 1025
Purity: ≥98%
Packaging: 25mg
Price: $341
Updated: 2024/03/01

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NU1025 Chemical Properties,Usage,Production

Description

NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC₅₀ = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.

Chemical Properties

Off-White to Pale Yellow Solid

Uses

NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.[Cayman Chemical]

Uses

A potent inhibitor of poly (ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively.

Definition

ChEBI: A member of the class of quinazolines that is quinazolin-4(1H)-one substituted by a hydroxy group at position 8 and a methyl group at position 2. It has been shown to exhibit inhibitory activity against poly(ADP-ribose) polymerase.

Biological Activity

Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). K i and IC 50 values are 48 and 400 nM respectively.

NU1025 Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Nitrogen N,N-Dimethylformamide Acetyl chloride 3-METHOXY-2-NITROBENZOIC ACID 2,3-DICHLORO-5,8-DIHYDROXY-1,4-NAPHTHOQUINONE Boron tribromide Tetrahydrofuran Hydrochloric acid Hydrogen Methanol Sodium hydroxide Pyridine Isopropyl alcohol Magnesium sulfate Thionyl chloride Ammonia

Preparation Products

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View Lastest Price from NU1025 manufacturers

Career Henan Chemical Co

Product: NU1025 90417-38-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98-100%
Supply Ability: 1000kg
Release date: 2018-08-20

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NU1025

PARP Inhibitor VI, NU1025 - CAS 90417-38-2 - Calbiochem

NU 1025;NU 1025

8-HYDROXY-2-METHYL-4(3H)-QUINAZOLINONE

8-HYDROXY-2-METHYLQUINAZOLIN-4[3H]-ONE

8-HYDROXY-2-METHYLQUINAZOLINE-4-ONE

8-Hydroxy-2-methylquinazoline-4-one ,97%

8-hydroxy-2-methyl-1H-quinazolin-4-one

NSC 696807

4(3H)-Quinazolinone, 8-hydroxy-2-Methyl-

8-hydroxy-2-methylquinazolin-4(1H)-one

8-Hydroxy-2-methylquinazolin-4(3H)

NU1025 (NSC 696807)

PARP Inhibitor VI, NU1025

NU1025 USP/EP/BP

90417-38-2

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