5-Bromo-2-fluorobenzylamine hydrochloride
- Product Name
- 5-Bromo-2-fluorobenzylamine hydrochloride
- CAS No.
- 99725-13-0
- Chemical Name
- 5-Bromo-2-fluorobenzylamine hydrochloride
- Synonyms
- RARECHEM AL BD 0325;5-BROMO-2-FLUOROBENZYL ALCOHOL;(5-BROMO-2-FLUOROPHENYL)METHANOL;Benzenemethanol, 5-bromo-2-fluoro-;5-Bromo-2-fluorobenzylamine hydrochloride;5-Bromo-2-fluorobenzylamine hydrochloride ISO 9001：2015 REACH
- CBNumber
- CB0218517
- Molecular Formula
- C7H6BrFO
- Formula Weight
- 205.02
- MOL File
- 99725-13-0.mol
5-Bromo-2-fluorobenzylamine hydrochloride Property
- Melting point:
- 221-226 °C(lit.)
- Boiling point:
- 82-87°/0.4mm
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 99725-13-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B692118
- Product name
- 5-Bromo-2-fluorobenzylAlcohol
- Packaging
- 10g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- PC7382
- Product name
- 5-Bromo-2-fluorobenzylalcohol
- Packaging
- 25g
- Price
- $134
- Updated
- 2021/12/16
- Product number
- 2601-B-12
- Product name
- 5-Bromo-2-fluorobenzyl alcohol
- Packaging
- 25g
- Price
- $175
- Updated
- 2021/12/16
- Product number
- FB151369
- Product name
- 5-Bromo-2-fluorobenzylalcohol
- Packaging
- 1g
- Price
- $207
- Updated
- 2021/12/16
- Product number
- FB151369
- Product name
- 5-Bromo-2-fluorobenzylalcohol
- Packaging
- 500mg
- Price
- $120
- Updated
- 2021/12/16
5-Bromo-2-fluorobenzylamine hydrochloride Chemical Properties,Usage,Production
Uses
5-Bromo-2-fluorobenzylamine hydrochloride is mainly used as an intermediate in organic synthesis, especially in the fields of medicine and materials science.
Synthesis
93777-26-5
99725-13-0
The general procedure for the synthesis of 5-bromo-2-fluorobenzyl alcohol from 5-bromo-2-fluorobenzaldehyde was as follows: sodium borohydride (8.39 g, 222 mmol) was slowly added to an ethanol (EtOH) solution of 5-bromo-2-fluorobenzaldehyde (30.0 g, 148 mmol) at 0 °C. The reaction mixture was stirred at 0 °C, followed by a gradual warming to room temperature over 15 h. The reaction was carried out at 0 °C. The reaction was carried out at 0 °C. The reaction was carried out at 0 °C. Upon completion of the reaction, the mixture was again cooled to 0 °C and the reaction was quenched with saturated aqueous ammonium chloride (NH4Cl) solution. The reaction mixture was extracted with ethyl acetate (EtOAc) and the organic layer was separated. The organic layer was subsequently washed with brine, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford 5-bromo-2-fluorobenzyl alcohol (30.3 g, quantitative yield) as a white solid, which can be used in subsequent reactions without further purification. [M-OH]+ 187.
References
[1] Patent: WO2011/159067, 2011, A2. Location in patent: Page/Page column 51
[2] Journal of Medicinal Chemistry, 1999, vol. 42, # 18, p. 3572 - 3587
[3] Patent: US6034093, 2000, A
[4] Patent: US5731315, 1998, A
[5] Patent: WO2004/814, 2003, A1. Location in patent: Page 49
5-Bromo-2-fluorobenzylamine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-2-fluorobenzylamine hydrochloride manufacturers
- Product
- 5-Bromo-2-fluorobenzylamine hydrochloride 99725-13-0
- Price
- US $9.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2024-12-02
- Product
- 5-Bromo-2-fluorobenzyl alcohol 99725-13-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2000kg
- Release date
- 2023-06-09
- Product
- 5-Bromo-2-fluorobenzylamine hydrochloride 99725-13-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11