5-Bromo-2-fluorobenzoic acid

Product Name: 5-Bromo-2-fluorobenzoic acid
CAS No.: 146328-85-0
Chemical Name: 5-Bromo-2-fluorobenzoic acid
Synonyms: CAS:146328-85-0;BUTTPARK 19\01-67;RARECHEM AL BO 0757;5-Bromo-2-fluorobenzoic;2-FLUORO-5-BROMOBENZOIC ACID;5-BROMO-2-FLUOROBENZOIC ACID;5-Bromo-2-fluorobenzoic aicd;2-Bromo-2-fluorobenzoic acid;5-Bromo-2-fluorobenzoicacid97%;5-Bromo-2-fluorobenzoicAcid>
CBNumber: CB7295993
Molecular Formula: C7H4BrFO2
Formula Weight: 219.01
MOL File: 146328-85-0.mol

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5-Bromo-2-fluorobenzoic acid Property

Melting point:: 141-145 °C (lit.)
Boiling point:: 296.5±25.0 °C(Predicted)
Density: 1.789±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 2.88±0.10(Predicted)
color: White to Light yellow to Light orange
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C7H4BrFO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,(H,10,11)
InChIKey: PEXAZYDITWXYNJ-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC(Br)=CC=C1F
CAS DataBase Reference: 146328-85-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22
Safety Statements: 26
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
HazardClass: IRRITANT
PackingGroup: Ⅲ
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 636452
Product name: 5-Bromo-2-fluorobenzoic acid
Purity: 97%
Packaging: 5g
Price: $120
Updated: 2023/06/20

Sigma-Aldrich

Product number: 636452
Product name: 5-Bromo-2-fluorobenzoic acid
Purity: 97%
Packaging: 1g
Price: $36.1
Updated: 2023/01/07

TCI Chemical

Product number: B2974
Product name: 5-Bromo-2-fluorobenzoic Acid
Purity: >97.0%(GC)(T)
Packaging: 1g
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: B2974
Product name: 5-Bromo-2-fluorobenzoic Acid
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: B2974
Product name: 5-Bromo-2-fluorobenzoic Acid
Purity: >97.0%(GC)(T)
Packaging: 25g
Price: $123
Updated: 2025/07/31

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5-Bromo-2-fluorobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

5-Bromo-2-fluorobenzoic acid is used as a pharmaceutical and organic intermediate.

Synthesis

445-29-4

146328-85-0

First, the sodium periodate solution was prepared: 7.7 g (36 mmol) of sodium periodate was dissolved in a solvent mixture of 40 ml of deionized water and 26 ml of acetic acid. Next, 10 g (71.4 mmol) of o-fluorobenzoic acid and 7.35 g (71.4 mmol) of sodium bromide were added to the reaction flask, followed by the addition of the prepared sodium periodate solution. The reaction system was heated to 30 °C and then 6.0 ml of concentrated sulfuric acid was added slowly and dropwise. After the dropwise addition, the temperature was raised to 50-65°C and maintained at this temperature for 2-3 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction solution was cooled to room temperature and poured into ice water. The precipitated solid was collected by filtration and the filter cake was washed several times with deionized water and dried to give 14.6 g of 2-fluoro-5-bromobenzoic acid in 87.9% yield.

References

[1] Journal of Organometallic Chemistry, 2008, vol. 693, # 18, p. 3081 - 3091
[2] Patent: CN107954852, 2018, A. Location in patent: Paragraph 0035-0037
[3] Patent: WO2017/46318, 2017, A1. Location in patent: Page/Page column 54

5-Bromo-2-fluorobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-2-fluorobenzoic acid Suppliers

Americas 1 China 262 Europe 4 Germany 6 India 10 Japan 2 Switzerland 1 Ukraine 3 United Kingdom 20 United States 45 Global 354

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View Lastest Price from 5-Bromo-2-fluorobenzoic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 5-Bromo-2-fluorobenzoic acid 146328-85-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Bromo-2-fluorobenzoic acid 146328-85-0
Price: US $0.10/KG
Min. Order: 0.1KG
Purity: 98%
Supply Ability: 200TONS
Release date: 2019-12-24

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Bromo-2-fluorobenzoic acid 146328-85-0
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2024-08-05

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5-Bromo-2-fluorobenzoic aicd

2-Bromo-2-fluorobenzoic acid

CAS:146328-85-0

146328-85-0

14638-85-0

BrC6H3FCOOH

C7H3BrFO2

Organic Building Blocks

Building Blocks

Carboxylic Acids

Carbonyl Compounds

C7

Fluorine series

Benzoic acid series

blocks

Bromides

Carboxes

FluoroCompounds

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

Benzoic acid

Miscellaneous

Acids & Esters

Bromine Compounds

Fluorine Compounds

C7

Carbonyl Compounds

Carboxylic Acids

Fluorin-contained Benzoic acid series