3-Bromo-2-fluorobenzoic acid

Product Name: 3-Bromo-2-fluorobenzoic acid
CAS No.: 161957-56-8
Chemical Name: 3-Bromo-2-fluorobenzoic acid
Synonyms: BUTTPARK 14\01-30;3-Bromo-2-fluorobenzoic;3-BROMO-2-FLUOROBENZOIC ACID;Benzoic acid, 3-bromo-2-fluoro-;3-Bromo-2-fluorobenzoic acid,98%;3-Bromo-2-fluorobenzoic Acid >3-Bromo-2-fluorobenzoic acid 97%+;3-Bromo-2-fluorobenzoic acid 97%;2-fluoro-3-bromobenzoic acid,3-Bromo-2-fluoro-benzoic acid,3-Bromo-2-Fluorobenzoic acid
CBNumber: CB1670749
Molecular Formula: C7H4BrFO2
Formula Weight: 219.01
MOL File: 161957-56-8.mol

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3-Bromo-2-fluorobenzoic acid Property

Melting point:: 168 °C
Boiling point:: 298.2±25.0 °C(Predicted)
Density: 1.789±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 2.88±0.10(Predicted)
color: White to Light yellow
InChI: InChI=1S/C7H4BrFO2/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3H,(H,10,11)
InChIKey: UVKURTLVTLRSSM-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=CC(Br)=C1F
CAS DataBase Reference: 161957-56-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
HazardClass: IRRITANT
HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B3929
Product name: 3-Bromo-2-fluorobenzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $37
Updated: 2025/07/31

TCI Chemical

Product number: B3929
Product name: 3-Bromo-2-fluorobenzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $111
Updated: 2025/07/31

TRC

Product number: B686025
Product name: 3-Bromo-2-fluorobenzoic Acid
Packaging: 100g
Price: $745
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0021197
Product name: 3-BROMO-2-FLUOROBENZOIC ACID
Purity: 95.00%
Packaging: 25G
Price: $625
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2621-B-32
Product name: 3-Bromo-2-fluorobenzoic acid
Purity: 98%
Packaging: 100g
Price: $200
Updated: 2021/12/16

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3-Bromo-2-fluorobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

Off-white powder

Uses

3-Bromo-2-fluorobenzoic acid is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 3-Bromo-2-fluorobenzoic acid is also used as a reagent to prepare Alkynlphenoxyacetic acid receptor agonists, compounds that can be potentially used for the treatment of allergic inflammatory diseases (such as allergic rhinitis).

Synthesis

1072-85-1

124-38-9

161957-56-8

1. n-Butyl lithium (n-BuLi, 240 mL of a 2.5 M solution, 600 mmol) was added dropwise to a tetrahydrofuran (THF, 500 mL) solution of diisopropylamine (84.3 mL, 600 mmol) at -30°C. 2. The resulting solution was stirred at -30°C for 30 minutes. 3. The mixture was added dropwise to a solution of 1-bromo-2-fluorobenzene (100 g, 571.43 mmol) in THF (500 mL) at -78° C. The solution was stirred for 30 minutes at -78° C. The mixture was then added to a solution of 1-bromo-2-fluorobenzene (100 g, 571.43 mmol). 4. After the addition, the resulting solution was stirred at -78°C for 2 hours. 5. The reaction mixture was poured over crushed solid carbon dioxide. 6. After removal of the solvent in vacuo, the resulting residue was diluted with water and washed with ether (2 x 500 mL). 7. The aqueous phase was acidified to pH 2 with 1N hydrochloric acid (HCl). 8. The precipitate was collected by filtration and dried to give 3-bromo-2-fluorobenzoic acid (90 g, 64% yield) as a white solid. 9. Mass spectrometry (MS) analysis showed m/z 221.0 (M + H+).

References

[1] Bulletin de la Societe Chimique de France, 1996, vol. 133, # 2, p. 133 - 141
[2] Patent: WO2011/119704, 2011, A1. Location in patent: Page/Page column 39-40
[3] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 12, p. 4158 - 4181
[4] Patent: US2009/203657, 2009, A1. Location in patent: Page/Page column 47
[5] Patent: US2009/203677, 2009, A1. Location in patent: Page/Page column 50

3-Bromo-2-fluorobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Bromo-2-fluorobenzoic acid Suppliers

Americas 1 CHINA 258 Europe 3 Germany 4 India 11 Italy 1 Japan 2 Poland 1 Slovakia 1 United Kingdom 12 United States 33 Global 327

Shanghai Harvest Chemical Industrial Co., Ltd.

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future industrial shanghai co., ltd

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View Lastest Price from 3-Bromo-2-fluorobenzoic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-Bromo-2-fluorobenzoic acid 161957-56-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-03

Shaanxi Dideu Medichem Co. Ltd

Product: 3-Bromo-2-fluorobenzoic acid 161957-56-8
Price: US $0.10/KG
Min. Order: 0.1KG
Purity: 99%HPLC
Supply Ability: 200TONS
Release date: 2019-12-24

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Chloro-6-fluorobenzoic acid 434-75-3
Price: US $0.10/KG
Min. Order: 0.1KG
Purity: 97%HPLC
Supply Ability: 200TONS
Release date: 2019-12-24

161957-56-8, 3-Bromo-2-fluorobenzoic acidRelated Search:

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3-Bromo-2-fluorobenzoic acid 97%

Benzoic acid, 3-bromo-2-fluoro-

BUTTPARK 14\01-30

3-BROMO-2-FLUOROBENZOIC ACID

3-Bromo-2-fluorobenzoic

3-Bromo-2-fluorobenzoic acid 97%+

3-Bromo-2-fluorobenzoic Acid &gt

2-fluoro-3-bromobenzoic acid,3-Bromo-2-fluoro-benzoic acid,3-Bromo-2-Fluorobenzoic acid

3-Bromo-2-fluorobenzoic acid,98%

161957-56-8

C7H4BrFO2

C7H4BrF2

Carboxylic acid

Benzoic acid

API intermediates

Acids and Derivatives

Halides

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts