3-Bromo-6-chloroimidazo[1,2-b]pyridazine

Product Name: 3-Bromo-6-chloroimidazo[1,2-b]pyridazine
CAS No.: 13526-66-4
Chemical Name: 3-Bromo-6-chloroimidazo[1,2-b]pyridazine
Synonyms: -Bromo-6-chloroimidazo[1,2-b]pyridazine;3-Bromo-6-chloroimidazo[1,2-b]pyridazine;6-Chloro-3-broMoiMidazo[1,2-a]pyridazine;3-Bromo-6-chloroimidazo[1,2-β]pyridazine;3-Bromo-6-chloroimidazo[1,2-b]pyridazine98%;IMidazo[1,2-b]pyridazine, 3-broMo-6-chloro-;3-Bromo-6-chloroimidazo[1,2-b]pyridazine ISO 9001：2015 REACH
CBNumber: CB21457357
Molecular Formula: C6H3BrClN3
Formula Weight: 232.47
MOL File: 13526-66-4.mol

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3-Bromo-6-chloroimidazo[1,2-b]pyridazine Property

Melting point:: 156 °C
Density: 2.03
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: Solid
pka: 0.73±0.30(Predicted)
Appearance: White to light yellow Solid

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Safety

Safety Statements: 24/25
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ANV00010
Product name: 3-Bromo-6-chloroimidazo[1,2-b]pyridazine
Purity: AldrichCPR
Packaging: 1G
Price: $185
Updated: 2025/07/31

TRC

Product number: B682330
Product name: 3-Bromo-6-chloroimidazo[1,2-b]pyridazine
Packaging: 2.5g
Price: $195
Updated: 2021/12/16

Matrix Scientific

Product number: 070532
Product name: 6-Chloro-3-bromoimidazo[1,2-a]pyridazine
Packaging: 25g
Price: $144
Updated: 2021/12/16

AK Scientific

Product number: X9912
Product name: 3-Bromo-6-chloroimidazo[1,2-b]pyridazine
Packaging: 10g
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB03946
Product name: 3-Bromo-6-chloroimidazo[1,2-b]pyridazine
Packaging: 1g
Price: $94.5
Updated: 2021/12/16

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3-Bromo-6-chloroimidazo[1,2-b]pyridazine Chemical Properties,Usage,Production

Uses

3-Bromo-6-chloroimidazo[1,2-b]pyridazine is a reagent in the synthesis of imidazopyridazine series of inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).

Synthesis

6775-78-6

13526-66-4

General procedure for the synthesis of 3-bromo-6-chloroimidazo[1,2-b]pyridazine from 6-chloroimidazo[1,2-b]pyridazine: 478 mg (3.11 mmol) of 6-chloroimidazo[1,2-b]pyridazine was dissolved in 10 mL of chloroform under the protection of argon and cooled in an ice bath. Subsequently, 664 mg (3.73 mmol) of N-bromosuccinimide was slowly added. After addition, the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was mixed with water and ethyl acetate, and the organic and aqueous phases were separated by the addition of saturated sodium bicarbonate solution. The aqueous phase was extracted three times with ethyl acetate. The organic phase was combined, washed with saturated sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to afford the target product 3-bromo-6-chloroimidazo[1,2-b]pyridazine as an amorphous white solid, which could be used in subsequent reactions without further chromatographic purification.1H-NMR (CDCl3, molecular sieve dried): δ = 7.12 (d, 1H); 7.79 (s, 1H); 7.90 (d, 1H) ppm.

References

[1] Patent: US2009/93475, 2009, A1. Location in patent: Page/Page column 6
[2] Patent: WO2013/34570, 2013, A1. Location in patent: Page/Page column 74
[3] Patent: WO2013/41634, 2013, A1. Location in patent: Page/Page column 73; 78; 87
[4] Patent: WO2013/144189, 2013, A1. Location in patent: Page/Page column 56
[5] Patent: WO2013/149909, 2013, A1. Location in patent: Page/Page column 60-61

3-Bromo-6-chloroimidazo[1,2-b]pyridazine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Bromo-6-chloroimidazo[1,2-b]pyridazine Suppliers

China 212 India 1 United Kingdom 3 United States 16 Global 232

J & K SCIENTIFIC LTD.

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China DongFan Chemical Co.,LTD

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View Lastest Price from 3-Bromo-6-chloroimidazo[1,2-b]pyridazine manufacturers

Shanghai Rlavie Technology Co ltd

Product: 3-Bromo-6-chloroimidazo[1,2-b]pyridazine;6-Chloro-3-broMoiMidazo[1,2-a]pyridazine 13526-66-4
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%minHPLC
Supply Ability: 10kgs/month
Release date: 2021-11-13

Honest Joy Holdings Limited

Product: 3-Bromo-6-chloroimidazo[1,2-b]pyridazine 13526-66-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.4%
Supply Ability: 100 tons
Release date: 2022-01-25

Dideu Industries Group Limited

Product: 3-Bromo-6-chloroimidazo[1,2-b]pyridazine 13526-66-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-11-01

13526-66-4, 3-Bromo-6-chloroimidazo[1,2-b]pyridazineRelated Search:

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3-Bromo-6-chloroimidazo[1,2-b]pyridazine

IMidazo[1,2-b]pyridazine, 3-broMo-6-chloro-

3-Bromo-6-chloroimidazo[1,2-b]pyridazine98%

3-Bromo-6-chloroimidazo[1,2-β]pyridazine

6-Chloro-3-broMoiMidazo[1,2-a]pyridazine

3-Bromo-6-chloroimidazo[1,2-b]pyridazine ISO 9001：2015 REACH

-Bromo-6-chloroimidazo[1,2-b]pyridazine

13526-66-4

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Bromides

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Imidazoles