3-Bromo-6-chloroimidazo[1,2-b]pyridazine
- Product Name
- 3-Bromo-6-chloroimidazo[1,2-b]pyridazine
- CAS No.
- 13526-66-4
- Chemical Name
- 3-Bromo-6-chloroimidazo[1,2-b]pyridazine
- Synonyms
- -Bromo-6-chloroimidazo[1,2-b]pyridazine;3-Bromo-6-chloroimidazo[1,2-b]pyridazine;6-Chloro-3-broMoiMidazo[1,2-a]pyridazine;3-Bromo-6-chloroimidazo[1,2-β]pyridazine;3-Bromo-6-chloroimidazo[1,2-b]pyridazine98%;IMidazo[1,2-b]pyridazine, 3-broMo-6-chloro-;3-Bromo-6-chloroimidazo[1,2-b]pyridazine ISO 9001：2015 REACH
- CBNumber
- CB21457357
- Molecular Formula
- C6H3BrClN3
- Formula Weight
- 232.47
- MOL File
- 13526-66-4.mol
3-Bromo-6-chloroimidazo[1,2-b]pyridazine Property
- Melting point:
- 156 °C
- Density
- 2.03
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Solid
- pka
- 0.73±0.30(Predicted)
- Appearance
- White to light yellow Solid
Safety
- Safety Statements
- 24/25
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- ANV00010
- Product name
- 3-Bromo-6-chloroimidazo[1,2-b]pyridazine
- Purity
- AldrichCPR
- Packaging
- 1G
- Price
- $185
- Updated
- 2025/07/31
- Product number
- B682330
- Product name
- 3-Bromo-6-chloroimidazo[1,2-b]pyridazine
- Packaging
- 2.5g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- 070532
- Product name
- 6-Chloro-3-bromoimidazo[1,2-a]pyridazine
- Packaging
- 25g
- Price
- $144
- Updated
- 2021/12/16
- Product number
- X9912
- Product name
- 3-Bromo-6-chloroimidazo[1,2-b]pyridazine
- Packaging
- 10g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- FB03946
- Product name
- 3-Bromo-6-chloroimidazo[1,2-b]pyridazine
- Packaging
- 1g
- Price
- $94.5
- Updated
- 2021/12/16
3-Bromo-6-chloroimidazo[1,2-b]pyridazine Chemical Properties,Usage,Production
Uses
3-Bromo-6-chloroimidazo[1,2-b]pyridazine is a reagent in the synthesis of imidazopyridazine series of inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).
Synthesis
6775-78-6
13526-66-4
General procedure for the synthesis of 3-bromo-6-chloroimidazo[1,2-b]pyridazine from 6-chloroimidazo[1,2-b]pyridazine: 478 mg (3.11 mmol) of 6-chloroimidazo[1,2-b]pyridazine was dissolved in 10 mL of chloroform under the protection of argon and cooled in an ice bath. Subsequently, 664 mg (3.73 mmol) of N-bromosuccinimide was slowly added. After addition, the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was mixed with water and ethyl acetate, and the organic and aqueous phases were separated by the addition of saturated sodium bicarbonate solution. The aqueous phase was extracted three times with ethyl acetate. The organic phase was combined, washed with saturated sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to afford the target product 3-bromo-6-chloroimidazo[1,2-b]pyridazine as an amorphous white solid, which could be used in subsequent reactions without further chromatographic purification.1H-NMR (CDCl3, molecular sieve dried): δ = 7.12 (d, 1H); 7.79 (s, 1H); 7.90 (d, 1H) ppm.
References
[1] Patent: US2009/93475, 2009, A1. Location in patent: Page/Page column 6
[2] Patent: WO2013/34570, 2013, A1. Location in patent: Page/Page column 74
[3] Patent: WO2013/41634, 2013, A1. Location in patent: Page/Page column 73; 78; 87
[4] Patent: WO2013/144189, 2013, A1. Location in patent: Page/Page column 56
[5] Patent: WO2013/149909, 2013, A1. Location in patent: Page/Page column 60-61
3-Bromo-6-chloroimidazo[1,2-b]pyridazine Preparation Products And Raw materials
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View Lastest Price from 3-Bromo-6-chloroimidazo[1,2-b]pyridazine manufacturers
- Product
- 3-Bromo-6-chloroimidazo[1,2-b]pyridazine;6-Chloro-3-broMoiMidazo[1,2-a]pyridazine 13526-66-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%minHPLC
- Supply Ability
- 10kgs/month
- Release date
- 2021-11-13
- Product
- 3-Bromo-6-chloroimidazo[1,2-b]pyridazine 13526-66-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.4%
- Supply Ability
- 100 tons
- Release date
- 2022-01-25
- Product
- 3-Bromo-6-chloroimidazo[1,2-b]pyridazine 13526-66-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-11-01