2-Bromo-5-fluorobenzoic acid
Uses- Product Name
- 2-Bromo-5-fluorobenzoic acid
- CAS No.
- 394-28-5
- Chemical Name
- 2-Bromo-5-fluorobenzoic acid
- Synonyms
- BUTTPARK 19\01-66;RARECHEM AL BO 0747;2-Bromo-5-fluorobenz;2-Bromo-5-Fluorobenzoic;2-BROMO-5-FLUOROBENZOIC ACID;2-bromo-5-fluorobenzoicacid,98%;Benzoic acid, 2-bromo-5-fluoro-;2-Bromo-5-fluorobenzoic Acid >2-Bromo-5-fluorobenzoic acid 98%;2-BroMo-5-fluorobenzoic Acid, 97+%
- CBNumber
- CB7249219
- Molecular Formula
- C7H4BrFO2
- Formula Weight
- 219.01
- MOL File
- 394-28-5.mol
2-Bromo-5-fluorobenzoic acid Property
- Melting point:
- 154-157 °C (lit.)
- Boiling point:
- 291.1±25.0 °C(Predicted)
- Density
- 1.789±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 2.51±0.10(Predicted)
- color
- White to Almost white
- BRN
- 2575978
- InChI
- InChI=1S/C7H4BrFO2/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3H,(H,10,11)
- InChIKey
- OQBMJMJZMDBQSM-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(F)=CC=C1Br
- CAS DataBase Reference
- 394-28-5(CAS DataBase Reference)
- EPA Substance Registry System
- Benzoic acid, 2-bromo-5-fluoro- (394-28-5)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-24/25
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B2722
- Product name
- 2-Bromo-5-fluorobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $117
- Updated
- 2025/07/31
- Product number
- B2722
- Product name
- 2-Bromo-5-fluorobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $385
- Updated
- 2025/07/31
- Product number
- B691983
- Product name
- 2-Bromo-5-fluorobenzoic acid
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB12070
- Product name
- 2-Bromo-5-fluorobenzoic acid
- Packaging
- 100g
- Price
- $87.5
- Updated
- 2021/12/16
- Product number
- 001714
- Product name
- 2-Bromo-5-fluorobenzoic acid
- Purity
- 98%
- Packaging
- 100g
- Price
- $59
- Updated
- 2021/12/16
2-Bromo-5-fluorobenzoic acid Chemical Properties,Usage,Production
Uses
2-Bromo-5-fluorobenzoic acid, a common organic synthesis intermediate, is primarily used to synthesize target molecular structures by utilizing the bromine and fluorine atoms on the benzene ring. For example, the bromine atom can undergo Suzuki coupling to introduce an aromatic ring or alkyl chain; or it can be converted into boric acid or borate esters, leveraging the versatility of borate esters to synthesize complex molecules. The fluorine atom can also undergo a series of transformations, including aromatic nucleophilic substitution reactions. Finally, the carboxyl group on the benzene ring can be readily converted into amides, esters, viboramides, etc.
Chemical Properties
white to light yellow crystal powder
Synthesis
2-Bromo-5-fluorobenzoic acid is synthesized from 5-(2′-bromophenoxy)benzothiazole and 2,3,4,5,6-pentafluorobenzoyl chloride in three steps. The synthesis involves bromination of benzothiazole with NBS followed by reaction with 4-fluoroaniline to give the intermediate which is then reacted with pentafluorobenzoyl chloride.
References
[1] Patent: WO2005/56544, 2005, A1. Location in patent: Page/Page column 46
2-Bromo-5-fluorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-5-fluorobenzoic acid manufacturers
- Product
- 2-Bromo-5-fluorobenzoic acid 394-28-5
- Price
- US $120.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20 tons
- Release date
- 2019-12-24
- Product
- 2-Bromo-5-fluorobenzoic acid 394-28-5
- Price
- US $0.10/KG
- Min. Order
- 0.1KG
- Purity
- 98%
- Supply Ability
- 200TONS
- Release date
- 2019-12-24
- Product
- 2-Bromo-5-fluorobenzoicacid 394-28-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.7%
- Supply Ability
- 100 tons
- Release date
- 2022-02-21