UTP

ChemicalBook > CAS DataBase List > UTP

Product Name: UTP
CAS No.: 63-39-8
Chemical Name: UTP
Synonyms: UTP-NA;UTP TRISODIUM SALT;pppU;5’-utp;uteplex;UTP, 3NA;Uracylic;UTP, NA3H;Urd-5'-P3;UTP Sodium
CBNumber: CB0221667
Molecular Formula: C9H15N2O15P3
Formula Weight: 484.14
MOL File: 63-39-8.mol

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UTP Property

Density: 2.106±0.06 g/cm3(Predicted)
Flash point:: 113 °C
storage temp.: Sealed in dry,2-8°C
pka: pK1:7.58 (25°C)
form: liquid
color: colorless
Water Solubility: Water : ≥ 150 mg/mL (309.83 mM)
CAS DataBase Reference: 63-39-8(CAS DataBase Reference)
EPA Substance Registry System: Uridine 5'-(tetrahydrogen triphosphate) (63-39-8)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-68/20/21/22
Safety Statements: 22-26-36
WGK Germany: 1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: U1006
Product name: Uridine 5′-triphosphate trisodium salt solution
Purity: HPLC purified, aqueous solution for RNA polymerase transcription
Packaging: 25μmol
Price: $123
Updated: 2024/03/01

Usbiological

Product number: 366675
Product name: Uridine Triphosphate
Packaging: 96Tests
Price: $954
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: APN0000293
Product name: URIDINE 5'-TRIPHOSPHATE
Purity: 95.00%
Packaging: 1G
Price: $1428
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573355
Product name: UTP, Trisodium Salt
Purity: >98%
Packaging: 1g
Price: $912.9
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NU03863
Product name: Uridine 5'-triphosphate trisodium salt
Packaging: 10g
Price: $120
Updated: 2021/12/16

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UTP Chemical Properties,Usage,Production

Description

Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.

Occurrence

Uridine 5'-triphosphate is a natural product found in Helianthus tuberosus, Apis cerana, and other organisms with data available.

Uses

Uridine 5′-triphosphate trisodium salt solution has been used to increase the intracellular Ca²⁺ levels in rat primary tracheal epithelial cells. It has also been used as a nucleotide substrate to analyze the activity of MutT homologue 1 (MTH1).

Definition

UTP is a pyrimidine ribonucleoside 5'-triphosphate having uracil as the nucleobase. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a pyrimidine ribonucleoside 5'-triphosphate and a uridine 5'-phosphate. It is a conjugate acid of an UTP(4-) and an UTP(3-).

Biochem/physiol Actions

P2Y receptor agonist

Pharmacokinetics

INS316 is a short-acting, aerosolized uridine 5-triphosphate (UTP) solution used as a diagnostic aid for lung cancer. INS316 appears to improve sputum expectoration mediated through the P2Y2 receptor, a nucleotide receptor expressed in human airway epithelial cells and some other tissues. UTP binding to the P2Y2 receptor triggers signal transduction that leads to chloride ion secretion, thereby resulting in mucociliary clearance of airway.

in vitro

Uridine triphosphate treatment induces Schwannoma cell migration through activation of P2Y2 receptors and through the increase of extracellular matrix metalloproteinase-2 (MMP-2) activation and expression. Uridine triphosphate-induced proliferation is mediated by protein kinase D, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, phosphatidylinositol 3-kinase (PI3K), Akt, and phospholipase D. Uridine triphosphate increases phosphorylation of Akt through protein kinase C, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, and PI3K.

in vivo

Uridine triphosphate reduces mitochondrial calcium levels following hypoxia. Early or late uridine triphosphate preconditioning is effective to reduce infarct size and superior myocardial function. Uridine triphosphate treatment increases the number of monocytes and macrophages infiltrating the pouch and up-regulates the gene expression of IL-4 and IL-13 in the regional lymph nodes.

References

[1]. Lamarca A, et al. Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation. PLoS One. 2014 Jun 6;9(6):e98998.
[2]. Choi JH, et al. Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor. Pancreas. 2013 May;42(4):680-6.
[3]. Yitzhaki S, et al. Uridine-5'-triphosphate (UTP) reduces infarct size and improves rat heart function aftermyocardial infarct. Biochem Pharmacol. 2006 Oct 16;72(8):949-55.
[4]. Iwaki Y, et al. Enhancement of antibody production against rabies virus by uridine 5'-triphosphate in mice. Microbes Infect. 2014 Mar;16(3):196-202.

UTP Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from UTP manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: UTP 63-39-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: UTP 63-39-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200kg
Release date: 2019-08-29

63-39-8, UTPRelated Search:

Uridine-5'-triphosphoric acid trisodium salt Uridine UDP-ALPHA-D-GALACTOSE DISODIUM SALT Uridine 5'-(trihydrogen diphosphate) P'-(6-azido-6-deoxy-alpha-D-glucopyranosyl) ester UTP TRIS SALT cytidine 3',5'-diphosphate Diquafosol Impurity 12 Diquafosol INS 365 DUTP, 100MM SOLUTION uridine 5'-tetraphosphate Diquafosol Impurity 10 UMP UDPGA TRISODIUM SALT URIDINE-13C9, 15N2-5 TRIPHOSPHATE SODI U UDP Uridine-5'-diphosphate disodium salt Uridine 5′-monophosphate disodium salt

5'-URIDYLATE TRIPHOSPHATE

UTP, 3NA

UTP-NA

UTP, NA3H

UTP SODIUM SALT

UTP TRISODIUM SALT

URIDINE 5'-TRIPHOSPHATE

URIDINE-5'-TRIPHOSPHATE NA3-SALT

URIDINE-5'-TRIPHOSPHATE SODIUM

URIDINE 5'-TRIPHOSPHATE SODIUM SALT

URIDINE 5-TRIPHOSPHATE TRISODIUM

URIDINE-5'-TRIPHOSPHATE TRISODIUM SALT

URIDINE-5'-TRIPHOSPHORIC ACID, TRISODIUM

5’-utp

uridine,5’-(tetrahydrogentriphosphate)

uridine5’-triphosphoricacid

uridinetriphosphate

uteplex

({[(2S,3R,4S,5S)-5-(2,4-dioxo-1,2,3,4-tetrahydropyriMidin-1-yl)-3,4-dihydroxyoxolan-2-yl]Methyl phosphonato}oxy)(phosphonatooxy)phosphinate

Uridine 5′-triphosphate trisodium salt solution

Uracylic

[[[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid

5'-uridylate triphosphate (UTP)

Uridine-5''-triphosphoric acid (and/or unspecified salts)

Uridine 5μ-triphosphate solution trisodium salt

pppU

Urd-5'-P3

UTP .Free Acid

Mix of 25 mM ATP, CTP, GTP and UTP Adenosine-5'-triphosphate, Sodium salt

Uridine-5'-triphosphate Free acid

UTP Solution (100mM)

((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate

triphosphoric acid 1-uridin-5'-yl ester

UTP Sodium

UTP 200mM Tris Solution, GMP grade

UTP 200mM Tris Solution

UTP Sodium Solution,UltraNUcTM?NTPs

Uridine 5'-(tetrahydrogen triphosphate)

Uridine 5'-triphosphate

63-39-8

C9H15N2O15P3

Nucleotides

DNA / RNA Synthesis

NTP

Elisa Kit-plant ELISA Kit