TRIS(2-AMINOETHYL)AMINE Property

Melting point:

-16 °C

Boiling point:

114 °C/15 mmHg (lit.)

Density 

0.976 g/mL at 20 °C (lit.)

vapor density 

5 (vs air)

vapor pressure 

0.02 mm Hg ( 20 °C)

refractive index 

n20/D 1.497(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

Chloroform (Sparingly), DMSO (Slightly)

form 

saline suspension

pka

10.00±0.10(Predicted)

color 

Clear yellow

Specific Gravity

0.977

Water Solubility 

Miscible with water.

Sensitive 

Hygroscopic

BRN 

1739626

Stability:

Stable. Hygroscopic. Absorbs carbon dioxide from the air. Incompatible with strong acids, strong oxidizing agents.

CAS DataBase Reference

4097-89-6(CAS DataBase Reference)

EPA Substance Registry System

1,2-Ethanediamine, N,N-bis(2-aminoethyl)- (4097-89-6)

Safety

Hazard Codes 

T,Xi

Risk Statements 

22-24-34-36/37/38-10

Safety Statements 

26-36/37/39-45-16

RIDADR 

UN 2922 8/PG 2

WGK Germany 

3

RTECS 

KH8587082

F 

3-10-23

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

II

HS Code 

29211990

Toxicity

mouse,LD50,oral,1800mg/kg (1800mg/kg),LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSIONBEHAVIORAL: ATAXIAGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA","Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 223, 1999.

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H310Fatal in contact with skin

H314Causes severe skin burns and eye damage

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

TRIS(2-AMINOETHYL)AMINE Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Uses

Tris(2-aminoethyl)amine is a tetradentate chelating ligand and forms stable complexes with transition metals. It is also used as a carbon dioxide absorbent. Further, it acts as a reagent for cleavage of the fluorenylmethyloxycarbonyl (Fmoc) group in peptide synthesis. It reacts with aryl isocyanates and isothiocyanates to give tris-urea and -thiourea derivatives.

Definition

ChEBI: Tris(2-aminoethyl)amine is a tetramine.

General Description

Tris(2-aminoethyl)amine (TREN) is a water soluble tripodal ligand that is majorly used in co-ordination chemistry. It has three aminoethylgroups that attach with the surface atoms to provide a scaffold assembly.

Hazard

A poison by ingestion and skin contact.

Safety Profile

A poison by ingestion and skin contact. When heated to decomposition it emits toxic vapors of NOx.

Purification Methods

For a separation from a mixture containing 62% TRIEN, see entry under triethylenetetramine. Also purify it by conversion to the hydrochloride (see below), recrystallise it and regenerate the free base [Xie & Hendrickson J Am Chem Soc 109 6981 1987]. [Beilstein 4 H 256, 4 II 695, 4 III 545, 4 IV 1250.]