ChemicalBook > CAS DataBase List > Tris(2-aminoethyl)amine

Tris(2-aminoethyl)amine

Product Name: Tris(2-aminoethyl)amine
CAS No.: 4097-89-6
Chemical Name: Tris(2-aminoethyl)amine
Synonyms: TREN;TAEA;tri(2-aminoethyl)amine;tris(aminoethyl)amine;trenhp;Tris(2-aminoethyL;Tris(2-aMinoethyl)a;Trientine Impurity 5;Triaminotriethyl-amine;N1,N1-Bis(2-aminoethyl)
CBNumber: CB0235693
Molecular Formula: C6H18N4
Formula Weight: 146.23
MOL File: 4097-89-6.mol

Less

Tris(2-aminoethyl)amine Property

Melting point:: -16 °C
Boiling point:: 114 °C/15 mmHg (lit.)
Density: 0.976 g/mL at 20 °C (lit.)
vapor density: 5 (vs air)
vapor pressure: 0.02 mm Hg ( 20 °C)
refractive index: n20/D 1.497(lit.)
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: Chloroform (Sparingly), DMSO (Slightly)
form: saline suspension
pka: 10.00±0.10(Predicted)
color: Clear yellow
Specific Gravity: 0.977
Water Solubility: Miscible with water.
Sensitive: Hygroscopic
BRN: 1739626
Stability:: Stable. Hygroscopic. Absorbs carbon dioxide from the air. Incompatible with strong acids, strong oxidizing agents.
CAS DataBase Reference: 4097-89-6(CAS DataBase Reference)
EPA Substance Registry System: 1,2-Ethanediamine, N,N-bis(2-aminoethyl)- (4097-89-6)

Less

Safety

Hazard Codes: T,Xi
Risk Statements: 22-24-34-36/37/38-10
Safety Statements: 26-36/37/39-45-16
RIDADR: UN 2922 8/PG 2
WGK Germany: 3
RTECS: KH8587082
F: 3-10-23
TSCA: Yes
HazardClass: 6.1
PackingGroup: II
HS Code: 29211990
Toxicity: mouse,LD50,oral,1800mg/kg (1800mg/kg),LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSIONBEHAVIORAL: ATAXIAGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA","Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 223, 1999.

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H310Fatal in contact with skin

H314Causes severe skin burns and eye damage

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 225630
Product name: Tris(2-aminoethyl)amine
Purity: 96%
Packaging: 10ml
Price: $56.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: 225630
Product name: Tris(2-aminoethyl)amine
Purity: 96%
Packaging: 100ml
Price: $275
Updated: 2025/07/31

TCI Chemical

Product number: T1243
Product name: Tris(2-aminoethyl)amine
Purity: >98.0%(T)
Packaging: 5mL
Price: $46
Updated: 2025/07/31

TCI Chemical

Product number: T1243
Product name: Tris(2-aminoethyl)amine
Purity: >98.0%(T)
Packaging: 25mL
Price: $135
Updated: 2025/07/31

Strem Chemicals

Product number: 07-2400
Product name: 2,2',2''-Triaminotriethylamine, min. 98% TREN
Packaging: 10g
Price: $37
Updated: 2024/03/01

Less

Tris(2-aminoethyl)amine Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Uses

Tris(2-aminoethyl)amine is a tetradentate chelating ligand and forms stable complexes with transition metals. It is also used as a carbon dioxide absorbent. Further, it acts as a reagent for cleavage of the fluorenylmethyloxycarbonyl (Fmoc) group in peptide synthesis. It reacts with aryl isocyanates and isothiocyanates to give tris-urea and -thiourea derivatives.

Definition

ChEBI: Tris(2-aminoethyl)amine is a tetramine.

General Description

Tris(2-aminoethyl)amine (TREN) is a water soluble tripodal ligand that is majorly used in co-ordination chemistry. It has three aminoethylgroups that attach with the surface atoms to provide a scaffold assembly.

Reactivity Profile

Tris(2-aminoethyl)amine (tren) is a commercially available tripodal amine, which has found wide application as a ligand in the preparation of metal complexes. Due to the tripodal arrangement of donor atoms, tren and various N-functionalised derivatives have been commonly employed in the preparation of trigonal bipyramidal metal complexes. More elaborate or extended tren ligands have been formed via substitution or condensation reactions with aldehydes. Metal complexes prepared therefrom have been employed in catalysis and oxygen binding studies. They have also been used to stabilise redox active oxoanions, such as thiosulfate, and to prepare cyano-bridged heteropolynuclear clusters with ferromagnetic properties. Less well explored are aryl-substituted tren ligand structures. However, some have been employed in the formation of transition metal amido complexes, which have been demonstrated to act as catalysts in dinitrogen reduction (Mo V and Cr complexes) and which have been tested in alkene epoxidation reactions (Fe and Mn complexes). Aryl-substituted tren-based ligands are generally synthesised via aryl substitution reactions using commercially available ArF compounds in 28– 99% yields. A different pathway to these aryl-substituted tren compounds involves Pd-mediated aromatic coupling, limited to commercially available ArBr compounds, affording the products 27–90% yields. More extended tren structures have been prepared via a two-step synthesis of the starting ArBr compound followed by Pd-mediated aromatic coupling in lower but acceptable overall yields of 36–45%. Given the versatility and demonstrated utility of these ligands, considerable benefit would be derived from new synthetic strategies that would broaden the range of accessible aryl-substituted tren ligands[2].

Hazard

A poison by ingestion and skin contact.

Safety Profile

A poison by ingestion and skin contact. When heated to decomposition it emits toxic vapors of NOx.

Purification Methods

For a separation from a mixture containing 62% TRIEN, see entry under triethylenetetramine. Also purify it by conversion to the hydrochloride (see below), recrystallise it and regenerate the free base [Xie & Hendrickson J Am Chem Soc 109 6981 1987]. [Beilstein 4 H 256, 4 II 695, 4 III 545, 4 IV 1250.]

References

[1] Bengang Zhang. “Highly Branched Tannin-Tris(2-aminoethyl)amine-Urea Wood Adhesives.” Polymers 15 4 (2023).
[2] Ann Almes?ker . “One-pot synthesis of tripodal tris(2-aminoethyl)amine derivatives from seven molecular components.” Tetrahedron Letters 50 16 (2009): Pages 1847-1850.

Tris(2-aminoethyl)amine Preparation Products And Raw materials

Raw materials

Congo Red Sodium hypochlorite Ammonium hydroxide Acrylamide 1,2-Dichloroethane Hydrochloric acid Methanol Sodium hydroxide

Preparation Products

Less

Tris(2-aminoethyl)amine Suppliers

Belgium 3 Canada 2 China 166 France 1 Germany 6 India 7 Japan 4 Spain 1 Switzerland 3 The Netherlands 2 United Kingdom 8 United States 31 Global 234

Ningbo Zhenyue Pharmaceutical Technology Co., Ltd

Tel: 19817745290
Email: bd@blocksynth.com
Country: China
ProdList: 5869
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-029-81024372 17792795018
Fax: 029-88380327
Email: 1027@dideu.com
Country: China
ProdList: 9996
Advantage: 58

Henan yingchuang

Tel: 16650708709
Fax: qq:778660296
Email: hnyingchuang@163.com
Country: China
ProdList: 3965
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
Advantage: 60

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Beijing innoChem Science & Technology Co.,Ltd.

Tel: 400-810-7969 010-59572699
Fax: 010-59572688
Email: ningzi.li@inno-chem.com.cn
Country: China
ProdList: 6134
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9546
Advantage: 55

AllyChem Co., Ltd.

Tel: 0411-62313318 13942603642
Fax: 0411-87549748
Email: info@allychem.com
Country: China
ProdList: 1028
Advantage: 65

Conier Chem & Pharma Co.,Ltd,

Tel: 023-62879767 13996269627;
Fax: +86-28-84559521
Email: sales@conier.com
Country: China
ProdList: 283
Advantage: 56

Shanghai Meishui Chemical Technology Co., Ltd

Tel: 021-60549325 18616193163
Fax: 021-33250306
Country: China
ProdList: 4526
Advantage: 56

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9979
Advantage: 55

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9476
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

Suzhou yacoo science co.,Ltd

Tel: 0512-87182056 18013166090
Fax: 0512-87182056
Email: lingling.qi@yacoo.com.cn
Country: China
ProdList: 6295
Advantage: 60

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

Chengdu RunZeBenTu Chemical Co., Ltd

Tel: 13096311329 028-88469284 616445927
Fax: 028-88469284
Email: 616445927@qq.com
Country: China
ProdList: 2874
Advantage: 50

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Shanghai Brain Biotechnology Co., Ltd.

Tel: 13564638271
Fax: 021-68948280
Email: shhjiang1977@163.com
Country: China
ProdList: 2987
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

BePharm Ltd

Tel: 400-685-9117
Fax: 021-51816740
Email: market@bepharm.com
Country: China
ProdList: 15081
Advantage: 60

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20794
Advantage: 60

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29759
Advantage: 68

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886750 13927877953
Fax: 0751-2886750
Email: 3005811397@qq.com
Country: China
ProdList: 13305
Advantage: 58

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 10007
Advantage: 58

Shanghai BaiShun Biological Technology Co., Ltd

Tel: 021-37581181
Fax: 021-57456066
Email: sales@chem-mall.com
Country: China
ProdList: 10330
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6039 18920764717
Email: sales@heowns.com
Country: China
ProdList: 23771
Advantage: 60

3A Chemicals

Tel: 400-668-9898
Fax: 010-51582189
Email: service@3achem.com
Country: China
ProdList: 20557
Advantage: 58

Nanjing Dilu Pharmaceutical Co., Ltd

Tel: 18014482516
Fax: QQ2853590738
Email: 977144864@qq.com
Country: China
ProdList: 378
Advantage: 58

Shanghai Anyinuo Biomedical Technology Co., Ltd.

Tel: 021-34625901 18018851262;
Email: 420970979@qq.com
Country: China
ProdList: 5894
Advantage: 58

Shanghai neon biological technology co., LTD

Tel: 021-54252912-8903
Email: leona.xin@forneeds.cn
Country: China
ProdList: 4759
Advantage: 58

Less

View Lastest Price from Tris(2-aminoethyl)amine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Tris(2-aminoethyl)amine 4097-89-6
Price: US $1.00-4.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2025-09-05

HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: TRIS(2-AMINOETHYL)AMINE 4097-89-6
Price: US $500.00/bag
Min. Order: 1bag
Purity: 0.99
Supply Ability: 1TON
Release date: 2024-12-03

Shaanxi Dideu New Materials Co. Ltd

Product: TRIS(2-AMINOETHYL)AMINE 4097-89-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2024-11-19

4097-89-6, Tris(2-aminoethyl)amineRelated Search:

Tris(m-methylanilino)melamine Tropine-3-thiol hydrochloride 1-(2-(5-(DIMETHYLAMINO)-1-NAPTHALENESULFONAMIDO)ETHYL)-1,4,7,10-TETRAAZACYCLODODECANE, TETRAHYDROCHLORIDE, DIHYDRATE Aspoxicillin Draflazine 2,8,9-TRIMETHYL-2,5,8,9-TETRAAZA-1-PHOSPHABICYCLO[3.3.3]UNDECANE CYCLEN-GLYOXAL TRIS(2-AMINOETHYL)AMINE TRIS(2-AMINOETHYL)AMINE POLYMER-BOUND,TRIS(2-AMINOETHYL)AMINE, POLYMER-SUPPORTED Ethylenediamine TRIS(2-(ISOPROPYLAMINO)ETHYL)AMINE DOTA-D-PHE-CYS-TYR-D-TRP-LYS-THR-CYS-THR-OL (DISULFIDE BRIDGE: 2-7) 2,8,9-Tri-i-butyl-2,5,8,9-tetraaza-1-phosphabicyclo[3.3.3]undecane DOTA-D-PHE-CYS-TYR-D-TRP-LYS-THR-CYS-THR-OH (DISULFIDE BRIDGE: 2-7) TRIS(2-DIMETHYLAMINOETHYL)AMINE N,N,N'-tris(2-aminoethyl)ethylenediamine TRIS(2-(METHYLAMINO)ETHYL)AMINE 97 2,8,9-TRI-I-PROPYL-2,5,8,9-TETRAAZA-1-PHOSPHABICYCLO[3.3.3]UNDECANE

tris(aminoethyl)amine

tris(beta-aminoethyl)amine

2,2',2''-Triaminotriethylamine,97%TREN

2,2'',2 -TRIAMINOTRIETHYLAMINE TREN

2,2μ,2μμ-Nitrilotriethylamine, 2,2μ,2μμ-Triaminotriethylamine, TAEA

2,2',2''-Nitrilotris(ethane-1-amine)

2,2',2''-Nitrilotrisethanamine

Tris(2-aminoethyl)amine ,95%

Tris(2-aMinoethyl)aMine, 96% 100ML

Tris(2-aMinoethyl)aMine, 96% 5ML

Tris(2-aminoethyl)amine,96%

Tris(2-aMinoethyl)a

Tris(2-aMinoethyl)aMine 96%

N1,N1-Bis(2-aminoethyl)

TAEA

TRIS(2-AMINOETHYL)AMINE

TREN

2,2',2''-TRIAMINOTRIETHYLAMINE

2,2',2''-NITRILOTRIETHYLAMINE

N1,N1-Bis-(2-amino-ethyl)-ethane-1,2-diamine

nitrilotris(ethylamine)

trenhp

tri(2-aminoethyl)amine

Triaminotriethyl-amine

2,2',2''-Triaminotriethylamine, min. 98% TREN

2,2’,2’’-nitrilotris(ethylamine)

2,2’,2’’-triaminotris(ethylamine)

4-(2-Aminoethyl)diethylene triamine

4-(2-aminoethyl)-diethylenetriamin

4-(2-Aminoethyl)diethylenetriamine

beta,beta’,beta’’-triaminotriethylamine

Tris(2-aminoethyL

1,2-Ethanediamine, N1,N1-bis(2-aminoethyl)-

Trientine Impurity 5

Tris(2-aminoethyl)amine, 98+%,

4097-89-6

C6H18N4

NCH2CH2NH23

NH2CH2CH23N

Building Blocks

Nitrogen Compounds

Organic Building Blocks

Polyamines