2-(Chloromethyl)thiophene
- Product Name
- 2-(Chloromethyl)thiophene
- CAS No.
- 765-50-4
- Chemical Name
- 2-(Chloromethyl)thiophene
- Synonyms
- Thenyl chloride;2-(chloromethyl)thiophene;THIOPHENE, 2-(CHLOROMETHYL)-;2-(Chloromethyl)thiophene###765-50-4;2-(Chloromethyl)thiophene ISO 9001：2015 REACH;2-(Chloromethyl)thiophene, 33% w/w solution in toluene
- CBNumber
- CB0238735
- Molecular Formula
- C5H5ClS
- Formula Weight
- 132.61
- MOL File
- 765-50-4.mol
2-(Chloromethyl)thiophene Property
- Boiling point:
- 80-81 °C(Press: 18 Torr)
- Density
- 1.243±0.06 g/cm3(Predicted)
- storage temp.
- Amber Vial, -20°C Freezer
- solubility
- Acetonitrile, Chloroform
- form
- Oil
- color
- Colourless
- CAS DataBase Reference
- 765-50-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Thiophene, 2-(chloromethyl)-(765-50-4)
Safety
- RIDADR
- 1993
- HazardClass
- 3
- PackingGroup
- Ⅲ
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B419458
- Product name
- 2-(Chloromethyl)thiophene
- Packaging
- 500mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- HCH0011564
- Product name
- 2-CHLOROMETHYLTHIOPHENE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $166.95
- Updated
- 2021/12/16
- Product number
- 189789
- Product name
- 2-(Chloromethyl)thiophene
- Packaging
- 5g
- Price
- $196
- Updated
- 2021/12/16
- Product number
- 189789
- Product name
- 2-(Chloromethyl)thiophene
- Packaging
- 10g
- Price
- $323
- Updated
- 2021/12/16
- Product number
- HCH0011564
- Product name
- 2-CHLOROMETHYLTHIOPHENE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $514.5
- Updated
- 2021/12/16
2-(Chloromethyl)thiophene Chemical Properties,Usage,Production
Chemical Properties
Colorless Liquid
Synthesis
636-72-6
765-50-4
The general procedure for the synthesis of 2-chloromethylthiophene from 2-thiophenemethanol was as follows: 2-thiophenemethanol (5,58 g, 509 mmol) and pyridine (60 g, 763 mmol) were dissolved in 600 mL of anhydrous dichloromethane at 0 °C, and thionyl chloride was added slowly and dropwise. The reaction mixture was stirred at 0°C for 1 hour, then brought to room temperature and continued to stir overnight. Upon completion of the reaction, the reaction was quenched by the addition of 500 mL of water. The organic layer was separated and the aqueous layer was extracted twice with 300 mL of dichloromethane. The organic layers were combined and washed sequentially with 600 mL of 5% aqueous sodium bicarbonate and 300 mL of brine. The organic layer was dried with anhydrous sodium sulfate and concentrated to give 40 g of 2-chloromethylthiophene (6) as an oil in 60% yield.
References
[1] European Journal of Medicinal Chemistry, 2001, vol. 36, # 11-12, p. 873 - 886
[2] European Journal of Pharmaceutical Sciences, 2002, vol. 16, # 1-2, p. 15 - 28
[3] European Journal of Organic Chemistry, 2014, vol. 2014, # 11, p. 2365 - 2370
[4] Tetrahedron, 1998, vol. 54, # 25, p. 6999 - 7012
[5] Synthetic Communications, 2005, vol. 35, # 15, p. 2079 - 2083
2-(Chloromethyl)thiophene Preparation Products And Raw materials
Raw materials
Preparation Products
2-(Chloromethyl)thiophene Suppliers
- Tel
- 18515581800 18501085097
- Fax
- 010-89508210
- sales.bj@hwrkchemical.com
- Country
- China
- ProdList
- 9400
- Advantage
- 55
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 022-66211289-843 13672102692
- Fax
- QQ：2377893365
- contact@sphinxpharm.com
- Country
- China
- ProdList
- 361
- Advantage
- 62
- Tel
- +86 (21) 5196-9732
- Fax
- +86 (21) 5196-9733
- Country
- China
- ProdList
- 996
- Advantage
- 57
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 6387
- Advantage
- 52
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 150-2103-5486 18017383231
- Fax
- qq：2817624287
- 983544897@qq.com
- Country
- China
- ProdList
- 9342
- Advantage
- 55
- Tel
- 021-58958002 18930822973
- Fax
- +86 (21) 5895-8628
- sales@uhnshanghai.com
- Country
- China
- ProdList
- 998
- Advantage
- 58
View Lastest Price from 2-(Chloromethyl)thiophene manufacturers
- Product
- 2-(Chloromethyl)thiophene 765-50-4
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-04-26
- Product
- 2-(Chloromethyl)thiophene 765-50-4
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2024-07-14
- Product
- 2-(Chloromethyl)thiophene 765-50-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11