5'-DEOXYTHYMIDINE

Product Name: 5'-DEOXYTHYMIDINE
CAS No.: 3458-14-8
Chemical Name: 5'-DEOXYTHYMIDINE
Synonyms: 5'-DEOXYTHYMIDINE;5'-DEOXYTHYMIDINE;Thymidine, 5'-deoxy-;2',5'-dideoxythymidine;2',5'-Dideoxy-5-methyluridine;5-Methyl-2',5'-dideoxyuridine;5 deoxy Thymidine,5deoxy Thymidine;1-[(2R,4S,5R)-4-hydroxy-5-methyloxolan-2-yl]-5-methylpyrimidine-2,4-dione;1-[(2R,4S,5R)-4-hydroxy-5-methyl-oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione;1-[(2R,4S,5R)-4-hydroxy-5-methyl-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-quinone
CBNumber: CB0244457
Molecular Formula: C10H14N2O4
Formula Weight: 226.23
MOL File: 3458-14-8.mol

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5'-DEOXYTHYMIDINE Property

Melting point:: 192-193 °C(lit.)
Density: 1.344±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: ≤10mg/ml in DMSO;16mg/ml in dimethyl formamide
form: crystalline solid
pka: 9.55±0.10(Predicted)
color: Off-white to light yellow

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18154
Product name: 5'-Deoxythymidine
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18154
Product name: 5'-Deoxythymidine
Purity: ≥95%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 18154
Product name: 5'-Deoxythymidine
Purity: ≥95%
Packaging: 10mg
Price: $214
Updated: 2024/03/01

TRC

Product number: D281783
Product name: 5''-Deoxythymidine
Packaging: 10mg
Price: $175
Updated: 2021/12/16

AK Scientific

Product number: 3736CA
Product name: 5'-Deoxythymidine
Packaging: 10mg
Price: $178
Updated: 2021/12/16

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5'-DEOXYTHYMIDINE Chemical Properties,Usage,Production

Uses

The pyrimidine thymidine consists of thymine combined with deoxyribose. Prior to polymerization into DNA, thymidine must be phosphorylated at the hydroxyl group on carbon 5 of the ribose moiety. 5'-Deoxythymidine is a form of thymidine in which the hydroxyl group on carbon 5 of ribose has been replaced with hydrogen. As a result, this compound cannot be phosphorylated and used by DNA polymerase in the synthesis of DNA. 5'-Deoxythymidine is readily imported by cellular nucleoside importers and competitively inhibits the influx of thymidine. It demonstrates antibacterial activity against B. subtilis and S. aureus.[Cayman Chemical]

Biological Activity

5'-deoxy thymidine has been used as a research tool for antiviral and anticancer studies. 5'-deoxy thymidine can be used to study the entry mechanism into human erythrocytes in comparison with other deoxythymidines. deoxythymidine, also named as thymidine, is the dna nucleoside t. deoxythymidine can pair with deoxyadenosine (a) in double-stranded dna. 5'-deoxy thymidine is a form of thymidine which had the hydroxyl group at the 5' position replaced with hydrogen [1]. 5'-deoxy thymidine (50 μg/ml) was effective against bacillus subtilis and staphylococcus aureus [1]. the mbc of 5'-deoxy thymidine was 50 μg/ml. 5'-deoxy thymidine has been used as an antibacterial agent in medical situations [1].thymidine has been phosphorylated at the hydroxyl group on carbon 5 of the ribose moiety before polymerization into dna. 5'-deoxy thymidine cannot be phosphorylated and used by dna polymerase in the synthesis of dna. in human erythrocytes, 5'-deoxy thymidine was readily and nonconcentratively uptaked by metabolism, and could be partially inhibited by nucleosides or inhibitors of nucleoside transport at micromolar concentrations [2].

References

[1] hatano a, nishimura m, souta i. impact of unnatural nucleosides on the control of microbial growth[j]. biocontrol science, 2009, 14(2): 55-60.
[2] domin b a, mahony w b, koszalka g w, et al. membrane permeation characteristics of 5'-modified thymidine analogs[j]. molecular pharmacology, 1992, 41(5): 950-956.

5'-DEOXYTHYMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5'-DEOXYTHYMIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5'-DEOXYTHYMIDINE 3458-14-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-08-01

3458-14-8, 5'-DEOXYTHYMIDINERelated Search:

3'-DEOXYTHYMIDINE 2'-DEOXYTHYMIDINE 5'-TRIPHOSPHORIC ACID,2'-DEOXYTHYMIDINE 5'-TRIPHOSPHATE 5-Methyluridine 5-HYDROXYMETHYL-2'-DEOXYURIDINE THYMIDINE 5'-TRIPHOSPHATE SODIUM SALT DMT-dT Phosphoramidite Trifluridine Thymidine 5'-O-Dimethoxytrityl-deoxythymidine 5'-O-Tritylthymidine 2'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE DISODIUM SALT 3'-AZIDO-3'-DEOXYTHYMIDINE 3'-FLUORO-3'-DEOXYTHYMIDINE 2',3'-DIDEHYDRO-3'-DEOXYTHYMIDINE,2',3'-DIHYDRO-2',3'-DEOXYTHYMIDINE 3'-DEOXYTHYMIDINE 5'-TRIPHOSPHATE SODIUM SALT 5'-DEOXYTHYMIDINE THYMIDINE 3'-MONOPHOSPHATE SODIUM SALT 5'-AMINO-5'-DEOXYTHYMIDINE

5'-DEOXYTHYMIDINE

2',5'-dideoxythymidine

1-[(2R,4S,5R)-4-hydroxy-5-methyl-oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione

1-[(2R,4S,5R)-4-hydroxy-5-methyloxolan-2-yl]-5-methylpyrimidine-2,4-dione

1-[(2R,4S,5R)-4-hydroxy-5-methyl-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-quinone

5-Methyl-2',5'-dideoxyuridine

2',5'-Dideoxy-5-methyluridine

Thymidine, 5'-deoxy-

Thymidine, 5'-deoxy-1-[(2R,4S,5R)-4-hydroxy-5-methyloxolan-2-yl]-5-methylpyrimidine-2,4-dione

5 deoxy Thymidine,5deoxy Thymidine

5'-DEOXYTHYMIDINE

3458-14-8

Building Blocks

Heterocyclic Building Blocks

Pyrimidines

Heterocyclic Compounds