5'-O-Tritylthymidine
- Product Name
- 5'-O-Tritylthymidine
- CAS No.
- 7791-71-1
- Chemical Name
- 5'-O-Tritylthymidine
- Synonyms
- Trt-dT;5'-O-Trt-dT;5'-O-Tritylthymidine;5'-O-Tritylthymidine;5'-O-Trt-deoxythymidine;5'-Trt-2'-deoxythymidine;5''-O-TRITYLTHYMIDINE(5-OTT);5'-O-Triphenylmethylthymidine;5’-o-(triphenylmethyl)-thymidin;5'-o-(Triphenylmethyl)thymidine
- CBNumber
- CB8667719
- Molecular Formula
- C29H28N2O5
- Formula Weight
- 484.54
- MOL File
- 7791-71-1.mol
5'-O-Tritylthymidine Property
- Melting point:
- 125 °C(Solv: acetone (67-64-1); ethyl ether (60-29-7))
- Density
- 1.275±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- pka
- 9.55±0.10(Predicted)
- form
- Solid
- color
- White to off-white
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P000258033
- Product name
- 5'-O-Tritylthymidine
- Purity
- 98% (contains <10%DCM)
- Packaging
- 250mg
- Price
- $5
- Updated
- 2021/12/16
- Product number
- P000258033
- Product name
- 5'-O-Tritylthymidine
- Purity
- 98% (contains <10%DCM)
- Packaging
- 1g
- Price
- $12
- Updated
- 2021/12/16
- Product number
- P000258033
- Product name
- 5'-O-Tritylthymidine
- Purity
- 98% (contains <10%DCM)
- Packaging
- 5g
- Price
- $47
- Updated
- 2021/12/16
- Product number
- NT08062
- Product name
- 5'-O-Tritylthymidine
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- P000258033
- Product name
- 5'-O-Tritylthymidine
- Purity
- 98% (contains <10%DCM)
- Packaging
- 10g
- Price
- $89
- Updated
- 2021/12/16
5'-O-Tritylthymidine Chemical Properties,Usage,Production
Uses
5'-O-Tritylthymidine is an inhibitor of TK-2 and inhibits angiogenesis[1]. 5'-O-Tritylthymidine targets FAK-Mdm-2 interactions, decreasing cell viability and increasing apoptosis.
Synthesis
76-83-5
50-89-5
7791-71-1
Triphenylchloromethane (15 g, 53.7 mmol) was slowly added to a solution of pyridine (40 mL) containing 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidin-2,4(1H,3H)-dione (10 g, 41.3 mmol) under nitrogen protection, and the reaction mixture was kept at room temperature for The reaction mixture was stirred for 21.5 hours at room temperature. Upon completion of the reaction, the reaction was quenched by the addition of saturated aqueous sodium bicarbonate solution to the system, followed by extraction and separation with dichloromethane. The organic phase was washed sequentially with saturated aqueous sodium chloride and dried over anhydrous sodium sulfate. The organic solvent was removed by concentration under reduced pressure, and the resulting crude product was purified by silica gel column chromatography (eluent ratio of ethyl acetate:n-hexane=1:1) to afford the target compound 1-((2R,4S,5R)-4-hydroxy-5-((triphenylmethoxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (19.4 g, 97.1% yield), as colorless acicular crystals. ), colorless needle-like crystals.
References
[1] Hernández A et al. Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase. J Med Chem. 2002 Sep 12;45(19):4254-63. DOI:10.1021/jm011128+
[2] Golubovskaya V et al. A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo. Anticancer Agents Med Chem. 2013 May;13(4):532-45. DOI:10.2174/1871520611313040002
5'-O-Tritylthymidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5'-O-Tritylthymidine manufacturers
- Product
- 5'-O-Tritylthymidine 7791-71-1
- Price
- US $0.00-0.00/G
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 2000
- Release date
- 2025-06-04
- Product
- 5'-O-Tritylthymidine 7791-71-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-23
- Product
- 5'-O-Tritylthymidine 7791-71-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- G/KG/T
- Release date
- 2019-12-23