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5'-O-Tritylthymidine

Product Name
5'-O-Tritylthymidine
CAS No.
7791-71-1
Chemical Name
5'-O-Tritylthymidine
Synonyms
Trt-dT;5'-O-Trt-dT;5'-O-Tritylthymidine;5'-O-Tritylthymidine;5'-O-Trt-deoxythymidine;5'-Trt-2'-deoxythymidine;5''-O-TRITYLTHYMIDINE(5-OTT);5'-O-Triphenylmethylthymidine;5’-o-(triphenylmethyl)-thymidin;5'-o-(Triphenylmethyl)thymidine
CBNumber
CB8667719
Molecular Formula
C29H28N2O5
Formula Weight
484.54
MOL File
7791-71-1.mol
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5'-O-Tritylthymidine Property

Melting point:
125 °C(Solv: acetone (67-64-1); ethyl ether (60-29-7))
Density 
1.275±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
pka
9.55±0.10(Predicted)
form 
Solid
color 
White to off-white
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
NT08062
Product name
5'-O-Tritylthymidine
Packaging
500mg
Price
$125
Updated
2021/12/16
AK Scientific
Product number
Z5120
Product name
5'-O-Tritylthymidine
Packaging
10g
Price
$150
Updated
2021/12/16
Biosynth Carbosynth
Product number
NT08062
Product name
5'-O-Tritylthymidine
Packaging
1g
Price
$210
Updated
2021/12/16
Matrix Scientific
Product number
097407
Product name
5'-O-Tritylthymidine
Purity
95+%
Packaging
1g
Price
$227
Updated
2021/12/16
Biosynth Carbosynth
Product number
NT08062
Product name
5'-O-Tritylthymidine
Packaging
2g
Price
$360
Updated
2021/12/16
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5'-O-Tritylthymidine Chemical Properties,Usage,Production

Uses

5'-O-Tritylthymidine is an inhibitor of TK-2 and inhibits angiogenesis[1]. 5'-O-Tritylthymidine targets FAK-Mdm-2 interactions, decreasing cell viability and increasing apoptosis.

Synthesis

76-83-5

50-89-5

7791-71-1

Triphenylchloromethane (15 g, 53.7 mmol) was slowly added to a solution of pyridine (40 mL) containing 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidin-2,4(1H,3H)-dione (10 g, 41.3 mmol) under nitrogen protection, and the reaction mixture was kept at room temperature for The reaction mixture was stirred for 21.5 hours at room temperature. Upon completion of the reaction, the reaction was quenched by the addition of saturated aqueous sodium bicarbonate solution to the system, followed by extraction and separation with dichloromethane. The organic phase was washed sequentially with saturated aqueous sodium chloride and dried over anhydrous sodium sulfate. The organic solvent was removed by concentration under reduced pressure, and the resulting crude product was purified by silica gel column chromatography (eluent ratio of ethyl acetate:n-hexane=1:1) to afford the target compound 1-((2R,4S,5R)-4-hydroxy-5-((triphenylmethoxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (19.4 g, 97.1% yield), as colorless acicular crystals. ), colorless needle-like crystals.

References

[1] Hernández A et al. Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase. J Med Chem. 2002 Sep 12;45(19):4254-63. DOI:10.1021/jm011128+
[2] Golubovskaya V et al. A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo. Anticancer Agents Med Chem. 2013 May;13(4):532-45. DOI:10.2174/1871520611313040002

5'-O-Tritylthymidine Preparation Products And Raw materials

Raw materials

Preparation Products

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5'-O-Tritylthymidine Suppliers

Canada 1 China 82 Germany 1 India 2 Russia 1 Switzerland 1 United Kingdom 3 United States 17 Global 108
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
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View Lastest Price from 5'-O-Tritylthymidine manufacturers

Shenzhen Nexcon Pharmatechs Ltd.
Product
5'-O-Tritylthymidine 7791-71-1
Price
US $0.00-0.00/G
Min. Order
1G
Purity
98%
Supply Ability
2000
Release date
2025-06-04
Henan Aochuang Chemical Co.,Ltd.
Product
5'-O-Tritylthymidine 7791-71-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-23
Career Henan Chemical Co
Product
5'-O-Tritylthymidine 7791-71-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
G/KG/T
Release date
2019-12-23

7791-71-1, 5'-O-TritylthymidineRelated Search:

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  • 5''-O-TRITYLTHYMIDINE(5-OTT)
  • 5-Methyl-5'-O-trityl-2'-deoxyuridine
  • 5'-O-Triphenylmethylthymidine
  • Thymidine, 5'-o-(triphenylmethyl)-
  • Trt-dT
  • 1-[5-[[2-(diphenylmethyl)phenoxy]methyl]-4-hydroxy-2-oxolanyl]-5-methylpyrimidine-2,4-dione
  • 5'-Trt-2'-deoxythymidine
  • 5'-O-Trt-deoxythymidine
  • 5’-o-(triphenylmethyl)-thymidin
  • 1-((2R,4S,5R)-4-Hydroxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
  • 1-((2R,4S,5R)-4-Hydroxy-5-((trityloxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
  • 5'-O-Trt-dT
  • 5'-O-Tritylthymidine
  • 5'-o-(Triphenylmethyl)thymidine
  • 5'-O-Tritylthymidine
  • 7791-71-1
  • Biochemicals and Reagents
  • Nucleosides, Nucleotides, Oligonucleotides
  • Nucleoside Analogs
  • BioChemical
  • Biochemicals and Reagents
  • Nucleoside Analogs
  • Nucleosides, Nucleotides, Oligonucleotides