WS 12

Product Name: WS 12
CAS No.: 68489-09-8
Chemical Name: WS 12
Synonyms: WS 12;AR-15512;Cooler-12;Cooling agent WS12;Cooler than menthol;WS 12, TRPM8 agonist;N-(4-Methoxyphenyl)-p-menthane-3-carboxamide;N- (4- methoxy phenyl) - menthol -3- carboxylase;N-(4-Methoxyphenyl)-p-menthane-3-carboxamide(WS-12);(2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboximide
CBNumber: CB02455758
Molecular Formula: C18H27NO2
Formula Weight: 289.41
MOL File: 68489-09-8.mol

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WS 12 Property

Boiling point:: 447.8±28.0 °C(Predicted)
Density: 1.029±0.06 g/cm3(Predicted)
vapor pressure: 0-0Pa at 20-50℃
FEMA: 4681 | (1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE
storage temp.: -20°C
solubility: DMSO: >20mg/mL
pka: 14.18±0.70(Predicted)
form: White to off-white powder.
color: white to off-white
Odor: at 100.00 %. cool minty
Odor Type: minty
JECFA Number: 2079
InChIKey: HNSGVPAAXJJOPQ-XOKHGSTOSA-N
LogP: 3.95 at 22℃ and pH7.7
CAS DataBase Reference: 68489-09-8

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Safety

Hazard Codes: N
Risk Statements: 50
Safety Statements: 53-61
RIDADR: UN 3077 9 / PGIII

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: W0519
Product name: WS-12
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $190
Updated: 2024/03/01

Tocris

Product number: 3040
Product name: WS12
Purity: ≥99%(HPLC)
Packaging: 10
Price: $141
Updated: 2021/12/16

Tocris

Product number: 3040
Product name: WS12
Purity: ≥99%(HPLC)
Packaging: 50
Price: $590
Updated: 2021/12/16

TRC

Product number: W500040
Product name: WS12
Packaging: 10mg
Price: $105
Updated: 2021/12/16

TRC

Product number: W500040
Product name: WS12
Packaging: 25mg
Price: $210
Updated: 2021/12/16

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WS 12 Chemical Properties,Usage,Production

Description

WS-12 is an agonist of transient receptor potential melastatin 8 (TRPM8). It induces currents in Xenopus oocytes expressing mouse TRPM8 (EC50 = 12 μM) and is selective for TRPM8 over transient receptor potential vanilloid 1-4 (TRPV1-4) and transient receptor potential ankyrin 1 (TRPA1) at 1 mM. WS-12 (6 nmol, i.c.v.) reduces nocifensive behavior induced by capsaicin in wild-type, but not Trpm8-/-, mice. It induces analgesia in the hot plate test, an effect that can be reversed by the opioid receptor antagonist naloxone, in mice.

Chemical Properties

WS 12 is a odorless white crystalline solid,mp 178 °C, displaying a strong initial cooling effect and a long-lastingness. It is used particularly is oral care flavors.

Uses

WS 12 is a potent TRPM8 agonist.

Trade name

Winsense WS-12 (Renessenz)

Biological Activity

Potent TRPM8 agonist that acts as a cooling agent (EC 50 = 193 nM).

Biochem/physiol Actions

WS-12 is a menthol derivative, that shows a specific binding affinity towards TRPM8 (transient receptor potential cation channel subfamily M member 8) receptor. TRPM8 is associated with prostate cancer and thus, WS-12 might be useful in reducing the progression of cancer.

storage

Store at -20°C

WS 12 Preparation Products And Raw materials

Raw materials

Preparation Products

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WS 12 Suppliers

China 108 India 1 United Kingdom 1 United States 15 USA 1 Global 126

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Alfa Chemistry

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Fax: 1-516-927-0118
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ProdList: 24072
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BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

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Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

ApexBio Technology

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ProdList: 6251
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Abcam

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Country: United States
ProdList: 6000
Advantage: 50

Cayman Chemical Company

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ProdList: 6213
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United States Biological

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ProdList: 6214
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Chemical sources Association Inc

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O'Laughlin Industries Inc.

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M&U International LLC

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MedChemExpress

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Riedel-de Haen AG

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ProdList: 6773
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View Lastest Price from WS 12 manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Cooling agent WS-12 68489-09-8
Price: US $25.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-04-25

Shaanxi Dideu Medichem Co. Ltd

Product: WS 12 68489-09-8
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2024-07-18

Hebei Shengyang Water Conservancy Engineering Co., Ltd.

Product: Cooling agent WS-12 68489-09-8
Price: US $18.00/kg
Min. Order: 1kg
Purity: 99.9
Supply Ability: 5000
Release date: 2024-05-10

68489-09-8, WS 12Related Search:

(2-(4-Iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium sodium salt WSB1 (A-10) WSP-5 5,7-Dihydro-2-methylthieno[3,4-d]pyrimidine WS6 WS3 WS-383 Menthoxypropanediol Cooler 5(WS-5) 2-Isopropyl-N,2,3-trimethylbutyramide WS 12

Cooling agent WS12

(1R,2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexane-1-carboxamide

WS 12

(1R*,2S*)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide

CyclohexanecarboxaMide, N-(4-Methoxyphenyl)-5-Methyl-2-(1-Methylethyl)-, (1R,2S,5R)-

(2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboximide

(1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE

Cyclohexanecarboxamide, N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)-

N- (4- methoxy phenyl) - menthol -3- carboxylase

N-(4-Methoxyphenyl)-p-menthane-3-carboxamide

N-(4-Methoxyphenyl)-p-menthane-3-carboxamide(WS-12)

Cooler than menthol

AR-15512

Cooler-12

HEK293T,AVX 012,chronic neuropathic pain,TRP Channel,AR 15512,inhibit,AVX012,WS 12,WS12,WS-12,AR15512,AVX-012,Inhibitor,AR-15512,Transient receptor potential channels,analgesic effect,cultured mouse DRG neurons

(1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide

WS 12, TRPM8 agonist

(1R,2S,5R)-2-isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboxamide

68489-09-8