Elvitegravir

Product Name: Elvitegravir
CAS No.: 697761-98-1
Chemical Name: Elvitegravir
Synonyms: EVG;CS-456;CS-789;D06677;JTK 303;GS 9137;Vitekta;For Mr Wei;Elvitegravi;Elvitegravir
CBNumber: CB02464875
Molecular Formula: C23H23ClFNO5
Formula Weight: 447.88
MOL File: 697761-98-1.mol

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Elvitegravir Property

Melting point:: 93-96°C
Boiling point:: 623.6±55.0 °C(Predicted)
Density: 1.357±0.06 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 0.44±0.20(Predicted)
form: Solid
color: Off-White to Pale Yellow
InChI: InChI=1S/C23H23ClFNO5/c1-12(2)19(11-27)26-10-16(23(29)30)22(28)15-8-14(20(31-3)9-18(15)26)7-13-5-4-6-17(24)21(13)25/h4-6,8-10,12,19,27H,7,11H2,1-3H3,(H,29,30)/t19-/m1/s1
InChIKey: JUZYLCPPVHEVSV-LJQANCHMSA-N
SMILES: N1([C@H](CO)C(C)C)C2=C(C=C(CC3=CC=CC(Cl)=C3F)C(OC)=C2)C(=O)C(C(O)=O)=C1
CAS DataBase Reference: 697761-98-1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17798
Product name: Elvitegravir
Purity: ≥98%
Packaging: 5mg
Price: $72
Updated: 2024/03/01

Cayman Chemical

Product number: 17798
Product name: Elvitegravir
Purity: ≥98%
Packaging: 10mg
Price: $135
Updated: 2024/03/01

Cayman Chemical

Product number: 17798
Product name: Elvitegravir
Purity: ≥98%
Packaging: 50mg
Price: $530
Updated: 2024/03/01

Cayman Chemical

Product number: 17798
Product name: Elvitegravir
Purity: ≥98%
Packaging: 100mg
Price: $915
Updated: 2024/03/01

Usbiological

Product number: 011073
Product name: Elvitegravir
Packaging: 10mg
Price: $375
Updated: 2021/12/16

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Elvitegravir Chemical Properties,Usage,Production

Description

In November 2013, the European Medicines Agency (EMA) approved elvitegravir (also known as GS 9137 and JTK 303) as a single agent to be used as part of an antiviral regimen that includes a ritonavir-boosted protease inhibitor for the treatment of HIV-1 in adults without mutations indicative of elvitegravir resistance. Elvitegravir is the second of three marketed HIV integrase strand transfer inhibitors (INSTIs) including raltegravir and dolutegravir (this volume of ARMC). Elvitegravir was discovered by modification of a literature naphthyridine HIV integrase inhibitor in which the naphthyridine core served as a bioisostere for the diketo acid moiety in an original series. Serendipitously, a 4-quinolone-3-carboxylic acid precursor en route to the desired bioisosteric glyoxylic acid demonstrated modest integrase inhibition (IC₅₀=1600 nM). Further derivatization led to elvitegravir with enhanced inhibition of integrase strand transfer (IC₅₀=7.2 nM) and significant antiviral activity (EC₅₀=0.9 nM). Elvitegravir was prepared in seven synthetic steps from 2,4-difluoro-5-iodobenzoic acid. The corresponding acid chloride was coupled to ethyl 3-(dimethylamino) acrylate and further substituted with S-valinol. Base promoted cyclization afforded the quinolone which was protected as silyl ether. Negishi coupling installed the 2-fluoro-3-chlorobenzyl moiety. Subsequent hydrolysis and methoxylation afforded elvitegravir.

Chemical Properties

Off-White to Pale Yellow Solid

Originator

Torii Pharmaceuticals (subsidiary of Japan Tobacco) (Japan)

Uses

Elvitegravir (EVG, JTK-303/GS-9137) is an HIV integrase inhibitor for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.

Uses

A novel inhibitor of human immunodeficiency virus type 1 integrase.

Uses

Elvitegravir is a quinolone antibiotic that inhibits the integrase of HIV-1 (IC50 = 7.2 nM). It blocks the integration of HIV-1 cDNA through the inhibition of DNA strand transfer. Elvitegravir is used in combination with a pharmacoenhancer and nucleoside/nucleotide reverse transcriptase inhibitors to block HIV-1 replication in vivo.[Cayman Chemical]

Definition

ChEBI: A quinolinemonocarboxylic acid that is 7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid substited at position 1 by a 1-hydroxy-3-methylbutan-2-yl group and at position 6 by a 3-chloro-2-fluorobenzyl group (the S-enantiomer). It is us d in combination therapy for the treatment of HIV-1 infection.

brand name

Vitekta? (Europe), Stribild? (as combo in the United States and Japan)

Synthesis

Commercial 2,4-dimethoxy-5-bromo benzoic acid (61) was reacted with 0.5 equiv of butylethylmagnesium to generate the dimagnesium salt in THF, which was then lithiated at 20 ?? to give the aryl lithium species. The aryl lithium species was then reacted with the 2-fluoro-3-chloro benzaldehyde (62) to give alcohol 63. Treatment with triethylsilane in TFA resulted in removal of the hydroxyl functionality to provide benzoic acid 64. This acid was then reacted with carbonyldiimidazole and subsequently magnesium malonate 65 to give ketoester 66 after workup. Next, condensation with DMF¨CDMA converted ketoester 66 to the vinylogous amide 67, and this material was immediately subjected to an addition¨Celimination reaction involving (S)-valinol (68) in toluene at ambient temperature to provide intermediate 69. Warming the resulting intermediate 69 in the presence of N,Obistrimethylsilyl acetamide (BSA) and potassium chloride in DMF furnished the ring-closed quinolone 70. The ester 70 was saponified with potassium hydroxide in aqueous isopropanol and then acidified and crystallized with the use of seed crystals. Upon cooling, the crystalline product elvitegravir (IX) was collected by filtration.

target

HIV-I integrase

Elvitegravir Preparation Products And Raw materials

Raw materials

Preparation Products

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Elvitegravir Suppliers

Canada 1 China 201 India 9 United Kingdom 2 United States 24 Global 237

Novachemistry

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Sequoia Research Products Ltd.

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View Lastest Price from Elvitegravir manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Elvitegravir 697761-98-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Elvitegravir 697761-98-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

BOC Sciences

Product: Elvitegravir 697761-98-1
Price: US $198.00/mg
Min. Order: 50mg
Purity: ≥98%
Supply Ability: 20g
Release date: 2020-05-15

697761-98-1, ElvitegravirRelated Search:

DELAVIRDINE Orlistat Tenofovir Foscarnet sodium Succinylcholine Chloride Glutathione ISOBUTANE Tenofovir disoproxil fumarate Emtricitabine Sofosbuvir Azelnidipine 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile BMS707035 GSK1349572 Raltegravir Etravirine Atazanavir sulfate 4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID

CS-789

CS-456

GS9137;GS-9137;GS 9137

Elvitegravir,EVG,GS-9137,JTK-303

(S)-6-(3-CHLORO-2-FLUOROBENZYL)-1-(1-HYDROXY-3-METHYLBUTAN-2-YL)-7-METHOXY-4-OXO

6-[(3-chloro-2-fluorophenyl)Methyl]-1-[(2S)-1-hydroxy-2,3-diMethylbutan-2-yl]-7-Methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

GS 9137

JTK 303

6-[(3-Chloro-2-fluorophenyl)Methyl]-1,4-dihydro-1-[(1S)-1-(hydroxyMethyl)-2-Methylpropyl]-7-Methoxy-4-oxo-3-quinolinecarboxylic Acid

D06677

EVG

Elvitegravir (GS-9137)

Vitekta

6-(3-Chloro-2-fluorobenzyl)-1-[1(S)-(hydroxymethyl)-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid Elvitegravir (GS-9137, JTK-303)

(S)-6-(3-CHLORO-2-FLUOROBENZYL)-1-(1-HYDROXY-3-METHYLBUTAN-2-YL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID

(S)-6-(3-Chloro-2-fluorobenzyl)-1-(1-hydroxy-3-methylBUTAN-2-YL)-7-methoxy-4-oxo-1,4-dihydroqu

1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

brand name: Stribild

GS-9137; GS9137; GS 9137; JTK 303; JTK-303; JTK303; EVG; ELVITEGRAVIR; BRAND NAME: STRIBILD

(S)-6-(3-CHLORO-2-FLUOROBENZYL)-1-(1-HYDROXY-2,3-DIMETHYLBUTAN-2-YL)-7-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID

Elvitegravir(GS-9137,JTK-303)

Elvitegravir

6-(3-Chloro-2-fluorobenzyl)-1-[1(S)-(hydroxymethyl)-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

(S)-6-(3-CHLORO-2-FLUOROBENZYL)-1-(1-HYDROXY-3-METHYLBUTAN-2-YL)-7-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID

3-Quinolinecarboxylic acid, 6-[(3-chloro-2-fluorophenyl)methyl]-1,4-dihydro-1-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-7-methoxy-4-oxo-

Elvitegravi

ELVITEGRAVIR CAS 697761-98-1

(S)-6-(3-CHLORO-2-FLUOROBENZYL)-1-(1-HYDROXY-3-METHYLBUTAN-2-YL)-7-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID USP/EP/BP

6-[(3-chloro-2-fluorophenyl)methyl]-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxoquinoline-3-carboxylic acid

ElvitegravirQ: What is Elvitegravir Q: What is the CAS Number of Elvitegravir Q: What is the storage condition of Elvitegravir Q: What are the applications of Elvitegravir

Elvitegravir (JTK-303)

For Mr Wei

Elvitegravir, quinolone HIV integrase inhibitor

697761-98-1

C23H23ClFNO5

API

Inhibitor

Aromatics

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

697761-98-1